Identifiers and Description

Gene Model Identifier

TTHERM_00794600

Standard Name

APN2 (APurinic Nuclease 2)

Aliases

PreTt21459 | 134.m00139 | APE1

Description

APN2 ExoIII family purinic/apyrimidinic (AP) endonuclease family animal Ape2 subfamily protein; Exodeoxyribonuclease III family protein; AP endonuclease; involved in base excision repair pathway

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• endonuclease activity (IEA) | GO:0004519
• nuclease activity (IEA) | GO:0004518

Biological Process

• DNA repair (IEA) | GO:0006281

Domains

• ( PF03372 ) Endonuclease/Exonuclease/phosphatase family
• ( TIGR00195 ) exodeoxyribonuclease III
• ( TIGR00633 ) exodeoxyribonuclease III (xth)
• ( TIGR03395 ) sphingomyelin phosphodiesterase

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_13338.1	9.997093137033517e-262
	Description: exodeoxyribonuclease III family protein (419 aa)
Oxytricha	Contig20170.0.g42	1.0004137340105782e-93
	Description: Endonuclease/Exonuclease/phosphatase family
DictyBase	DDB_G0277701	4.000392704867155e-81
	Description: apeA on chromosome: 2 position 8367690 to 8368775
WormBase	WBGene00001372	9.996907204735647e-62
	Description: locus:exo-3 status:Confirmed UniProt:G5EBR7 protein_id:CAB03235.1
WormBase	WBGene00000487	9.996907204735647e-62
	Description: locus:che-6 status:Partially_confirmed UniProt:O61827 protein_id:CCD65345.2
Stentor Coeruleus	SteCoe_20039	1.3336148155022614e-34
	Description: None
SGD	YBL019W	0.000000005997038937208364
	Description: APN2 Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII

General Information

No Data fetched for General Information

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00794600(coding)
ATGATTAAATCTTTTAGATTTTCAGCTTCTAGTCTTTTAAATTTTAGAAACCAATGCTTT
AATACTTAACGTGTAGGTAAGGTATTTTATGCGCCAAAGTTATTAACTTTCCCACTGTTG
AAGTAAAATTTTACTCAGCTCGAAAAAGGCTCAGACTTGCAATAATCAGTAGAAAAATAA
ACTAAAAAGAAAAAAGGTATGAGTAAAATAATTAAAAAATCAAGCTCTATTTCAGAGCCT
GAATAGTCGTAGTCCAGTACTACTACTTAAAAGACTAAAAAGCAGGCTCAATTAGGTGAT
TTCTTTGCTGGAATAAAAAAAAAACCTGAGACCTAAGTTGAAGATAAAGTAGAAATAAAT
ACAGAATTAGGAGATGGAATTTGGAAAGATCGTTAAAATATTAAAATAGCATGTTGGAAT
GTGAATGGATTAAGAGCTGTTTTGAAAAGAGAAGACTTATAAAAGTATATAAAGTAAGAA
AATCCTGATATTCTATGCCTAAATGAAACTAAAATAGATGAATCGAATTTTATAAAAGAA
AAAGTATACAAAGATATTCCTTCAGGCTATTACTAATATTGGAATTTCTGTATACCACCA
ATTAAGGGTTACTCTGGCGTTTCTATTTTCTCTAAAGAAAAAGTCATTAGCATTAAAAAA
GGTATAGATATTGCAGAGCACGAGAACGAAGGAAGGGTTCTTACAGCTGAATTCGATAAA
TTTTATTTAGTTGTAGTTTATGTCCCTAATGCAGGATCGGAATTAGTTAGACTAGATTAT
AGAGTTAATTCGTTTGATAAAGACTTTCAAAATTATTTAAACTAACTAAAATTGAAAAAA
AATGTGATTCTTTGTGGTGATTTAAATGTAGCTCACTAAGAAATAGATATAGCTAATCCC
AAATCTAATAGAAACTCTCCAGGATTTACAATTGAAGAAAGGAATAGCTTTAGTAAATTT
TTAGAAAGTGGATGGATAGATACATTTAGATTTTTATATCCAGAAACTATAAAATATTCT
TGGTGGAGTGTTAGAACTAAAGCTAGAGAATCAAATATAGGATGGAGAATAGATTATTTC
GTTGTAAATAAAGAATTTAAGTCCTCTATTAAAGACTCTATGATAAATAATAATATCTAT
GGAAGTGACCATTGTCCAGTTGAATTTATTTTAAATTTAGATGCTATTTAATAAAATGAA
ACTTCTTCAAACGAAAATACATAAACAAATAAATCTAATTGA

>TTHERM_00794600(gene)
ATGATTAAATCTTTTAGATTTTCAGCTTCTAGTCTTTTAAATTTTAGAAACCAATGCTTT
AATACTTAACGTGTAGGTAAGGTATTTTATGCGCCAAAGTTATTAACTTTCCCACTGTTG
AAGTAAAGTAATAATAATTATAGTATTACCGCCTAAAGATATTAAATAATATATTGAATT
TTTAAAATTTAGATTTTACTCAGCTCGAAAAAGGCTCAGACTTGCAATAATCAGTAGAAA
AATAAACTAAAAAGAAAAAAGGTATGAGTAAAATAATTAAAAAATCAAGCTCTATTTCAG
AGCCTGAATAGTCGTAGTCCAGTACTACTACTTAAAAGACTAAAAAGCAGGCTCAATTAG
GTGATTTCTTTGCTGGAATAAAAAAAAAACCTGAGACCTAAGTTGAAGATAAAGTAGAAA
TAAATACAGAATTAGGAGATGGAATTTGGAAAGATCGTTAAAATATTAAAATAGCATGTT
GGAATGTGAATGGATTAAGAGCTGTTTTGAAAAGAGAAGACTTATAAAAGTATATAAAGT
AAGAAAATCCTGATATTCTATGCCTAAATGAAACTAAAATAGATGAATCGAATTTTATAA
AAGAAAAAGTATACAAAGATATTCCTTCAGGCTATTACTAATATTGGTAATTTTATCAAA
AAACTATAATTTTTAGTTTTACATTTCTAAAAATATTAAAAAACAAATAAATAATTTTAT
AAATAATTAACATAATAATAGATTAATGAATTAAATTAATTTAGCTTTAATATTGTTATA
AGAATTTATTAAATACATAAATTAATAAACTAAAAAGGAATTTCTGTATACCACCAATTA
AGGGTTACTCTGGCGTTTCTATTTTCTCTAAAGAAAAAGTCATTAGCATTAAAAAAGGTA
TAGATATTGCAGAGCACGAGAACGAAGGAAGGGTTCTTACAGCTGAATTCGATAAATTTT
ATTTAGTTGTAGTTTATGTCCCTAATGCAGGATCGGAATTAGTTAGACTAGATTATAGAG
TTAATTCGTTTGATAAAGACTTTCAAAATTATTTAAACTAACTAAAATTGAAAAAAAATG
TGATTCTTTGTGGTGATTTAAATGTAGCTCACTAAGAAATAGATATAGCTAATCCCAAAT
CTAATAGAAACTCTCCAGGATTTACAATTGAAGAAAGGAATAGCTTTAGTAAATTTTTAG
AAAGTGGATGGATAGATACATTTAGATTTTTATATCCAGAAACTATAAAATATTCTTGGT
GGAGTGTTAGAACTAAAGCTAGAGAATCAAATATAGGATGGAGAATAGATTATTTCGTTG
TAAATAAAGAATTTAAGTCCTCTATTAAAGACTCTATGATAAATAATAATATCTATGGAA
GTGACCATTGTCCAGTTGAATTTATTTTAAATTTAGATGCTATTTAATAAAATGAAACTT
CTTCAAACGAAAATACATAAACAAATAAATCTAATTGA

>TTHERM_00794600(protein)
MIKSFRFSASSLLNFRNQCFNTQRVGKVFYAPKLLTFPLLKQNFTQLEKGSDLQQSVEKQ
TKKKKGMSKIIKKSSSISEPEQSQSSTTTQKTKKQAQLGDFFAGIKKKPETQVEDKVEIN
TELGDGIWKDRQNIKIACWNVNGLRAVLKREDLQKYIKQENPDILCLNETKIDESNFIKE
KVYKDIPSGYYQYWNFCIPPIKGYSGVSIFSKEKVISIKKGIDIAEHENEGRVLTAEFDK
FYLVVVYVPNAGSELVRLDYRVNSFDKDFQNYLNQLKLKKNVILCGDLNVAHQEIDIANP
KSNRNSPGFTIEERNSFSKFLESGWIDTFRFLYPETIKYSWWSVRTKARESNIGWRIDYF
VVNKEFKSSIKDSMINNNIYGSDHCPVEFILNLDAIQQNETSSNENTQTNKSN