Identifiers and Description

Gene Model Identifier

TTHERM_00825440

Standard Name

TOP2 (TOPoisomerase II)

Aliases

PreTt04008 | 142.m00105 | 3683.m00038

Description

TOP2 DNA topoisomerase IV; DNA gyrase/topoisomerase IV, A subunit family protein; DNA Topoisomerase II Enzyme

Genome Browser (Macronucleus)

Full Screen View


Genome Browser (Micronucleus)

Full Screen View

External Links

Gene Ontology Annotations

No Data fetched for Gene Ontology Annotations

Domains

  • ( PF00204 ) DNA gyrase B
  • ( PF00521 ) DNA gyrase/topoisomerase IV, subunit A
  • ( PF01751 ) Toprim domain
  • ( PF02518 ) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
  • ( PF16898 ) C-terminal associated domain of TOPRIM

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

No Data fetched for Homologs

General Information

No Data fetched for General Information

Associated Literature

  1. Ref:28621664: Akematsu T, Fukuda Y, Garg J, Fillingham JS, Pearlman RE, Loidl J (2017) Post-meiotic DNA double-strand breaks occur in Tetrahymena, and require Topoisomerase II and Spo11. eLife 6( ):

Sequences 

>TTHERM_00825440(coding)
ATGAGCAAGCAGGAAAAATCAGTAGAAGAAAGATATTAAAAAAAATCCCAAATTGAGCAT
ATTCTTCTTCGTCCTGACTCTTATGTTGGGTCTATAGAAAATGAATAAAAGTCATTATGG
ATTCTAAACAAGGAGGGAACAGCATTAGAAGAAAAAGAAATAGATTTCGTTCCAGCATTT
TATAAAATATTTGATGAAATTATAGTCAATGCTGCAGATAACTTTTAAAGAAATTAAGAT
GGAGCTCCTATGGATACAATAAAAGTTATGATTGATCAATAAAATCAAATGATCTCAGTT
TGGAATAATGGACAAGGAATCCCTATATAAATTCATAAAGAGCATAATATTTATATTCCA
GAAATGATTTTTGGTCATCTATTAACAAGCTCTAATTACGATGATAAAGAAGAGAAAGTA
GTAGGCGGTCGTAATGGATTTGGTGCTAAATTAACAAATATTTTTTCTAAAAAATTCATT
GTTGAATGCAATGATGACAAGCGTAAAAAATATTACAAGTAAGAATGGCGTAAAAATATG
TCTGAAAGAACAGAGCCTTTGATTACAGAAAATAAAAAAGGTGGTAATTTCACATGTGTA
ACATTCTATCCTGACCTTTCTAAATTCAAGATGCAAAATATTTCTGATGATATGGCAAAT
TTACTAAGAAAAAGAGTTTATGATATGGCTGGTATTTTTAACAATAAGGTCAAAGTTTAT
TTGAATAATGAACAAATAAAAATAAAATCCTTTAGTTAATATGTTAACTTGTTTATACCT
GACATTGAAGAACAATACAAATGCTATGATCCAACTATGACTTCTGACAGATGGGAGATT
TTAGTTACTTTTTCAGATGGTTAATTTAAGTAAGTATCGTTTGTAAATGGTATTTGCACA
TCTAGAGGTGGTAAGCATGTAGATTTTGTCATTGATAAAATTGTTGAGAGAATGCAAGAA
TAAATCTTGAAAAAGAATAAAGATCTTGATATCAAGCCTCATTAAATCAAACAAAATTTA
TTCATATTTATGAATTGCCTTATTGTTAACCCTTCGTTTGATTCTCAAACCAAAGACACT
CTTACAACAAAAGCCTCAGCTTTTGGATCAAAACCTGAATTATCAGAAAAATTTATCAAA
AAAATATTGGGTACTGGTATCATTGAGTAAATTGTTTCCTAAGCTAAAGCTCGTCAGAAT
GCTAAATTAGCAAAAACTTTAAAGGGTGGGAAAAAAGGAAGAATTACAGGTATCCCAAAA
CTTGATGATGCTAATGATGCAGGAACAGCAAGAAGTGAAAACTGTACATTAATCTTAACC
GAAGGAGATTCAGCTAAAGCATTAGCAATGGCTGGTATAGAAGTTGTAGGTAGGGATAAT
TATGGTGTATTCCCATTAAAGGGTAAGCTACTTAATGTTAGAGAAGCAAATAAGAAATAG
ATCATCGAAAACCAAGAAATATAAAATATATGCAAAATCATAGGGCTAGATCCTGCTGTT
TAAAACTATGAAAATACAAAGCAATTAAGGTACGGATCTTTAATGATCATGGCTGATTAG
GATAGTGATGGTTCCCATATTAAAGGTTTGGTCATAAACTTTATTCATCACTTCTGGCCT
TCTCTGTTTAAAATGAAAGGGTTTTTAAAAGAATTTATTACTCCCATCCTTAAAGTTACA
AAAGGAGATGAAGTTCATTCATTCTTTACAATATAAGATTTCAAAAATTTTGCTGCTTAA
AAAGGAGACCGCCTTAAGTAATACAAAGTTAAGTACTACAAAGGTCTTGGTACTTCGACT
GACAAAGAAGCTAAAGAATATTTCTCCAATTTCTATAAGCATCAAATTAATTTTTAATAT
TTAGATGAAAACGATATGGAAGCTATTGAATTAGGTTTTTCAGGTAAAAAAATAAAAGAA
CGTAAGGACTGGCTAGCTAATTATGATCCTAATTCATTTGTTGATTATAATATAAAATAA
TTAAGATACAAGGATTTTATTGATAGAGAGCTTATTCACTTCTCAAATGCTGATAATTTA
AGATCTATCCCATCGTTATGTGATGGCCTAAAGCCTGGTCAAAGAAAAATTCTATTTTCT
TGTTTTAAAAGAAATTTAAAATCAGAAATCAAAGTAGCTTAATTAATTGGTTATGTTGCT
GAGCACTCTGCATATCACCACGGTGAATAATCACTCGCTTCAACTATCATCGGAATGGCA
TAAAATTTTGTAGGTTCTAATAATATAAATCTTATGATGCCTATTGGTTAGTTTGGTACA
CGTAATCAAGGTGGAAAAGAGCATGCCTCTGCAAGATACATTTTTACAAGTCTGAGCAAA
ATTACTAGAATACTTTTTCCAGAGCATGATGATCATGTACTGAAGTATTTAGAAGACGAT
AATCAAGTAGTAGAACCAGAATGGTACATGCCAATTATTCCTATGTGTTTAGTAAATGGT
AGTAGTGGTATTGGTACTGGTTGGTCAACTGATATTCCTAACTATAATCACAAGGAAATT
GTTGAATAAATTAGAGGGAAGCTGGAAGGAAAGCCATTTACTGAATTACATCCTTGGTAC
AAAGGATTTTAAGGTTAAATAGAAATTAATCCTAAAGGTGGGTATATAGTCAAAGGGTAA
TACGAAATCGATGAAGTTGAAGAAACAATAAAAATTACTGAATTACCTGTTGGTAAATGG
ACAAGAGACTATAAGAATTATTTAGAAGAGCTACTATCACCACCAAAAGGAGAACCTGAA
ATTGAAGACATTCGTGAATATCATACAAATAATAGAGTTCATTTTGAAGTACAAGCAATA
CCAGGGAGAATATAATAATGGGGTGACATTGAGAAAAAGCTTAAATTAAGCACAACAATG
CAAACAACTAATATAGTTATGTTTAATGATAAATATAAATTAAAAAGATATCAAAGTACT
GTAGAAATAATGGAAGAATTTTATGCTTTACGTCTCAAATGCTACTAAAAAAGAAAAGAT
TATTTAGTCAGCAAAATTCAAAGAGATGTTGATATTTTATAAAATAAGATGAAATTTATT
ACATTAGTTGTCAATGGTACTTTGGAAATTAGAAATGCCAGAAAGAAAGGAGTTCTGAAT
AAACTTAAGGAGTTAGGTCTGACTCCAATGTCAAAAATAACCAGAATCAATTCGACAAAA
ATCTAGGCATTTGAAGAAAAAAAGAAAGAAAGTTAAGCTGAAAAAAATGAAGATAATGAA
GATGAAGAAGTTTAATAAGACGAAGAGGAAGAAGAAGAATAAGTTTAAGAAGGAGAAATT
CCTTTATCTGAATACAACTACCTTCTCTCTATGCCTATCTTTTCTTTGACAGAAGAAAAG
GTATTATAACTCAAAAAATAAGTAGAAGAAAAGGAAAGTGAACTTTTGATCTTATAAAAG
AAAGAAATAAAAGATATGTGGACAGAAGATTTAGATAAATTCATAGAAGTTATTGAATAA
GTAGAAGAAAAAGAAGAAAAAGAGAGACTTACAGGTAAAGGGTTTACATAGAATGGCAAA
GCCCGTGCTAAAAAGAAAAATAACAATAAAGAAAAAGAATAAAAAAAATAATAAAATAAC
TCTTCAGATGACGAAAGCGAAAAGAAAACTGTTGTAAAAAATAAAAATCCATAAAAATCT
GATAATGAAAAATAAAAGCCAAAAGAAAATAATGATAAATAAAAGAAAATAGATGAAAGT
TTTCTTGTGAAGAAAAAAATGGATGCAGAACAATAAAAAACAGAAGAAAAGGTATAAAAG
AAAGAATAGAAGAAAGAGCCAATGAAGTAGCTCTCACTGATTGAAAGAATATCTTAAAAA
TATAGTAATCAGGCGGAATAATAAGTAACGGCAGATATACTTGACACAAATAAACGTAAA
AAAGATCCATCTTCAACTTCTACCTCTGTTTATTCAATGGATATGCCATAATAAAACCTA
AAGCGAAAGAAAAATAATAAATTGAAAGAAGATGATGATGATTTTGACCTTGATTTAGAT
TTCTTAGAACCTAGTTAGATAATTATGAATCCTAGCTAAGATCCTAATAAAAGAACCTTA
AGGTCAAATGGGAAGAAGCCAAGAACGATTTATAAACTAGATTCGGATTCTGATAATGAT
GAATTCAATCAGTAAAATGATGAATCTGATGAAGAAGAGGAAGAGGAATTTGTTATGATG
CCTTCTAAGAGCAATAAGAAAAAATTATTTGATGAGGATGAGGATGATTGA



>TTHERM_00825440(gene)
ACTTAAAAAAATTAGCGCAAAAAATCCTTAAAAATAAACGAAATCATTGAATTTAGATTA
AATTTAAAATTTTAAAAACTTTAGAAAATAATAAACTGCTGTAAAAGTATCATTTAAAGC
AATCTTTTAATAAATTAGCATATTAAAATGAGCAAGCAGGAAAAATCAGTAGAAGAAAGA
TATTAAAAAAAATCCCAAATTGAGCATATTCTTCTTCGTCCTGACTCTTATGTTGGGTCT
ATAGAAAATGAATAAAAGTCATTATGGATTCTAAACAAGGAGGGAACAGCATTAGAAGAA
AAAGAAATAGATTTCGTTCCAGCATTTTATAAAATATTTGATGAAATTATAGTCAATGCT
GCAGATAACTTTTAAAGAAATTAAGATGGAGCTCCTATGGATACAATAAAAGTTATGATT
GATCAATAAAATCAAATGATCTCAGTTTGGAATAATGGACAAGGAATCCCTATATAAATT
CATAAAGAGCATAATATTTATATTCCAGAAATGATTTTTGGTCATCTATTAACAAGCTCT
AATTACGATGATAAAGAAGAGAAAGTAGTAGGCGGTCGTAATGGATTTGGTGCTAAATTA
ACAAATATTTTTTCTAAAAAATTCATTGTTGAATGCAATGATGACAAGCGTAAAAAATAT
TACAAGTAAGAATGGCGTAAAAATATGTCTGAAAGAACAGAGCCTTTGATTACAGAAAAT
AAAAAAGGTGGTAATTTCACATGTGTAACATTCTATCCTGACCTTTCTAAATTCAAGATG
CAAAATATTTCTGATGATATGGCAAATTTACTAAGAAAAAGAGTTTATGATATGGCTGGT
ATTTTTAACAATAAGGTCAAAGTTTATTTGAATAATGAACAAATAAAAATAAAATCCTTT
AGTTAATATGTTAACTTGTTTATACCTGACATTGAAGAACAATACAAATGCTATGATCCA
ACTATGACTTCTGACAGATGGGAGATTTTAGTTACTTTTTCAGATGGTTAATTTAAGTAA
GTATCGTTTGTAAATGGTATTTGCACATCTAGAGGTGGTAAGCATGTAGATTTTGTCATT
GATAAAATTGTTGAGAGAATGCAAGAATAAATCTTGAAAAAGAATAAAGATCTTGATATC
AAGCCTCATTAAATCAAACAAAATTTATTCATATTTATGAATTGCCTTATTGTTAACCCT
TCGTTTGATTCTCAAACCAAAGACACTCTTACAACAAAAGCCTCAGCTTTTGGATCAAAA
CCTGAATTATCAGAAAAATTTATCAAAAAAATATTGGGTACTGGTATCATTGAGTAAATT
GTTTCCTAAGCTAAAGCTCGTCAGAATGCTAAATTAGCAAAAACTTTAAAGGGTGGGAAA
AAAGGAAGAATTACAGGTATCCCAAAACTTGATGATGCTAATGATGCAGGAACAGCAAGA
AGTGAAAACTGTACATTAATCTTAACCGAAGGAGATTCAGCTAAAGCATTAGCAATGGCT
GGTATAGAAGTTGTAGGTAGGGATAATTATGGTGTATTCCCATTAAAGGGTAAGCTACTT
AATGTTAGAGAAGCAAATAAGAAATAGATCATCGAAAACCAAGAAATATAAAATATATGC
AAAATCATAGGGCTAGATCCTGCTGTTTAAAACTATGAAAATACAAAGCAATTAAGGTAC
GGATCTTTAATGATCATGGCTGATTAGGATAGTGATGGTTCCCATATTAAAGGTTTGGTC
ATAAACTTTATTCATCACTTCTGGCCTTCTCTGTTTAAAATGAAAGGGTTTTTAAAAGAA
TTTATTACTCCCATCCTTAAAGTTACAAAAGGAGATGAAGTTCATTCATTCTTTACAATA
TAAGATTTCAAAAATTTTGCTGCTTAAAAAGGAGACCGCCTTAAGTAATACAAAGTTAAG
TACTACAAAGGTCTTGGTACTTCGACTGACAAAGAAGCTAAAGAATATTTCTCCAATTTC
TATAAGCATCAAATTAATTTTTAATATTTAGATGAAAACGATATGGAAGCTATTGAATTA
GGTTTTTCAGGTAAAAAAATAAAAGAACGTAAGGACTGGCTAGCTAATTATGATCCTAAT
TCATTTGTTGATTATAATATAAAATAATTAAGATACAAGGATTTTATTGATAGAGAGCTT
ATTCACTTCTCAAATGCTGATAATTTAAGATCTATCCCATCGTTATGTGATGGCCTAAAG
CCTGGTCAAAGAAAAATTCTATTTTCTTGTTTTAAAAGAAATTTAAAATCAGAAATCAAA
GTAGCTTAATTAATTGGTTATGTTGCTGAGCACTCTGCATATCACCACGGTGAATAATCA
CTCGCTTCAACTATCATCGGAATGGCATAAAATTTTGTAGGTTCTAATAATATAAATCTT
ATGATGCCTATTGGTTAGTTTGGTACACGTAATCAAGGTGGAAAAGAGCATGCCTCTGCA
AGATACATTTTTACAAGTCTGAGCAAAATTACTAGAATACTTTTTCCAGAGCATGATGAT
CATGTACTGAAGTATTTAGAAGACGATAATCAAGTAGTAGAACCAGAATGGTACATGCCA
ATTATTCCTATGTGTTTAGTAAATGGTAGTAGTGGTATTGGTACTGGTTGGTCAACTGAT
ATTCCTAACTATAATCACAAGGAAATTGTTGAATAAATTAGAGGGAAGCTGGAAGGAAAG
CCATTTACTGAATTACATCCTTGGTACAAAGGATTTTAAGGTTAAATAGAAATTAATCCT
AAAGGTGGGTATATAGTCAAAGGGTAATACGAAATCGATGAAGTTGAAGAAACAATAAAA
ATTACTGAATTACCTGTTGGTAAATGGACAAGAGACTATAAGAATTATTTAGAAGAGCTA
CTATCACCACCAAAAGGAGAACCTGAAATTGAAGACATTCGTGAATATCATACAAATAAT
AGAGTTCATTTTGAAGTACAAGCAATACCAGGGAGAATATAATAATGGGGTGACATTGAG
AAAAAGCTTAAATTAAGCACAACAATGCAAACAACTAATATAGTTATGTTTAATGATAAA
TATAAATTAAAAAGATATCAAAGTACTGTAGAAATAATGGAAGAATTTTATGCTTTACGT
CTCAAATGCTACTAAAAAAGAAAAGATTATTTAGTCAGCAAAATTCAAAGAGATGTTGAT
ATTTTATAAAATAAGATGAAATTTATTACATTAGTTGTCAATGGTACTTTGGAAATTAGA
AATGCCAGAAAGAAAGGAGTTCTGAATAAACTTAAGGAGTTAGGTCTGACTCCAATGTCA
AAAATAACCAGAATCAATTCGACAAAAATCTAGGCATTTGAAGAAAAAAAGAAAGAAAGT
TAAGCTGAAAAAAATGAAGATAATGAAGATGAAGAAGTTTAATAAGACGAAGAGGAAGAA
GAAGAATAAGTTTAAGAAGGAGAAATTCCTTTATCTGAATACAACTACCTTCTCTCTATG
CCTATCTTTTCTTTGACAGAAGAAAAGGTATTATAACTCAAAAAATAAGTAGAAGAAAAG
GAAAGTGAACTTTTGATCTTATAAAAGAAAGAAATAAAAGATATGTGGACAGAAGATTTA
GATAAATTCATAGAAGTTATTGAATAAGTAGAAGAAAAAGAAGAAAAAGAGAGACTTACA
GGTAAAGGGTTTACATAGAATGGCAAAGCCCGTGCTAAAAAGAAAAATAACAATAAAGAA
AAAGAATAAAAAAAATAATAAAATAACTCTTCAGATGACGAAAGCGAAAAGAAAACTGTT
GTAAAAAATAAAAATCCATAAAAATCTGATAATGAAAAATAAAAGCCAAAAGAAAATAAT
GATAAATAAAAGAAAATAGATGAAAGTTTTCTTGTGAAGAAAAAAATGGATGCAGAACAA
TAAAAAACAGAAGAAAAGGTATAAAAGAAAGAATAGAAGAAAGAGCCAATGAAGTAGCTC
TCACTGATTGAAAGAATATCTTAAAAATATAGTAATCAGGCGGAATAATAAGTAACGGCA
GATATACTTGACACAAATAAACGTAAAAAAGATCCATCTTCAACTTCTACCTCTGTTTAT
TCAATGGATATGCCATAATAAAACCTAAAGCGAAAGAAAAATAATAAATTGAAAGAAGAT
GATGATGATTTTGACCTTGATTTAGATTTCTTAGAACCTAGTTAGATAATTATGAATCCT
AGCTAAGATCCTAATAAAAGAACCTTAAGGTCAAATGGGAAGAAGCCAAGAACGATTTAT
AAACTAGATTCGGATTCTGATAATGATGAATTCAATCAGTAAAATGATGAATCTGATGAA
GAAGAGGAAGAGGAATTTGTTATGATGCCTTCTAAGAGCAATAAGAAAAAATTATTTGAT
GAGGATGAGGATGATTGAATTTATTGCTGATTTTATTAAATAATAAATATTTTTATATAG
AAAATGAAGTTTAATTTTTATAGTTGAGTATATATTTTATTTATTTAGGGTAGAGTTTTA
ATTAATTGTATTAAATTAATCAATTTTAT



>TTHERM_00825440(protein)
MSKQEKSVEERYQKKSQIEHILLRPDSYVGSIENEQKSLWILNKEGTALEEKEIDFVPAF
YKIFDEIIVNAADNFQRNQDGAPMDTIKVMIDQQNQMISVWNNGQGIPIQIHKEHNIYIP
EMIFGHLLTSSNYDDKEEKVVGGRNGFGAKLTNIFSKKFIVECNDDKRKKYYKQEWRKNM
SERTEPLITENKKGGNFTCVTFYPDLSKFKMQNISDDMANLLRKRVYDMAGIFNNKVKVY
LNNEQIKIKSFSQYVNLFIPDIEEQYKCYDPTMTSDRWEILVTFSDGQFKQVSFVNGICT
SRGGKHVDFVIDKIVERMQEQILKKNKDLDIKPHQIKQNLFIFMNCLIVNPSFDSQTKDT
LTTKASAFGSKPELSEKFIKKILGTGIIEQIVSQAKARQNAKLAKTLKGGKKGRITGIPK
LDDANDAGTARSENCTLILTEGDSAKALAMAGIEVVGRDNYGVFPLKGKLLNVREANKKQ
IIENQEIQNICKIIGLDPAVQNYENTKQLRYGSLMIMADQDSDGSHIKGLVINFIHHFWP
SLFKMKGFLKEFITPILKVTKGDEVHSFFTIQDFKNFAAQKGDRLKQYKVKYYKGLGTST
DKEAKEYFSNFYKHQINFQYLDENDMEAIELGFSGKKIKERKDWLANYDPNSFVDYNIKQ
LRYKDFIDRELIHFSNADNLRSIPSLCDGLKPGQRKILFSCFKRNLKSEIKVAQLIGYVA
EHSAYHHGEQSLASTIIGMAQNFVGSNNINLMMPIGQFGTRNQGGKEHASARYIFTSLSK
ITRILFPEHDDHVLKYLEDDNQVVEPEWYMPIIPMCLVNGSSGIGTGWSTDIPNYNHKEI
VEQIRGKLEGKPFTELHPWYKGFQGQIEINPKGGYIVKGQYEIDEVEETIKITELPVGKW
TRDYKNYLEELLSPPKGEPEIEDIREYHTNNRVHFEVQAIPGRIQQWGDIEKKLKLSTTM
QTTNIVMFNDKYKLKRYQSTVEIMEEFYALRLKCYQKRKDYLVSKIQRDVDILQNKMKFI
TLVVNGTLEIRNARKKGVLNKLKELGLTPMSKITRINSTKIQAFEEKKKESQAEKNEDNE
DEEVQQDEEEEEEQVQEGEIPLSEYNYLLSMPIFSLTEEKVLQLKKQVEEKESELLILQK
KEIKDMWTEDLDKFIEVIEQVEEKEEKERLTGKGFTQNGKARAKKKNNNKEKEQKKQQNN
SSDDESEKKTVVKNKNPQKSDNEKQKPKENNDKQKKIDESFLVKKKMDAEQQKTEEKVQK
KEQKKEPMKQLSLIERISQKYSNQAEQQVTADILDTNKRKKDPSSTSTSVYSMDMPQQNL
KRKKNNKLKEDDDDFDLDLDFLEPSQIIMNPSQDPNKRTLRSNGKKPRTIYKLDSDSDND
EFNQQNDESDEEEEEEFVMMPSKSNKKKLFDEDEDD