Identifiers and Description

Gene Model Identifier

TTHERM_00825440

Standard Name

TOP2 (TOPoisomerase II)

Aliases

PreTt04008 | 142.m00105 | 3683.m00038

Description

TOP2 DNA topoisomerase IV; DNA gyrase/topoisomerase IV- A subunit family protein

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• chromosome (IEA) | GO:0005694

Molecular Function

• ATP binding (IEA) | GO:0005524
• DNA binding (IEA) | GO:0003677
• DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity (IEA) | GO:0003918

Biological Process

• DNA topological change (IEA) | GO:0006265

Domains

• ( PF00204 ) DNA gyrase B
• ( PF00521 ) DNA gyrase/topoisomerase IV, subunit A
• ( PF02518 ) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
• ( TIGR01055 ) DNA topoisomerase IV, B subunit
• ( TIGR01058 ) DNA topoisomerase IV, B subunit
• ( TIGR01059 ) DNA gyrase, B subunit
• ( TIGR01062 ) DNA topoisomerase IV, A subunit
• ( TIGR01063 ) DNA gyrase, A subunit

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Stentor Coeruleus	SteCoe_19754	0
	Description: None
WormBase	WBGene00010785	9.997093137033517e-262
	Description: locus:top-2 Probable DNA topoisomerase 2 status:Partially_confirmed UniProt:Q23670 protein_id:CAA88867.1
Tetrahymena borealis	EI9_18275.1	9.997093137033517e-262
	Description: DNA gyrase/topoisomerase IV, A subunit protein (1796 aa)
DictyBase	DDB_G0270418	9.997093137033517e-262
	Description: top2 on chromosome: 1 position 4831688 to 4836353
Oxytricha	Contig14442.0.g108	9.997093137033517e-262
	Description: DNA gyrase/topoisomerase IV, subunit A
SGD	YNL088W	9.997093137033517e-262
	Description: TOP2 Topoisomerase II, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis
WormBase	WBGene00004400	9.997093137033517e-262
	Description: locus:rom-1 Rhomboid-related protein 1 status:Partially_confirmed UniProt:Q19821 protein_id:CCD65751.1
Tetrahymena borealis	EI9_10527.1	9.997093137033517e-262
	Description: hypothetical protein (694 aa)

General Information

No Data fetched for General Information

Associated Literature

1. Ref:28621664: Akematsu T, Fukuda Y, Garg J, Fillingham JS, Pearlman RE, Loidl J (2017) Post-meiotic DNA double-strand breaks occur in Tetrahymena, and require Topoisomerase II and Spo11. eLife 6( ):

Sequences

>TTHERM_00825440(coding)
ATGAGCAAGCAGGAAAAATCAGTAGAAGAAAGATATTAAAAAAAATCCCAAATTGAGCAT
ATTCTTCTTCGTCCTGACTCTTATGTTGGGTCTATAGAAAATGAATAAAAGTCATTATGG
ATTCTAAACAAGGAGGGAACAGCATTAGAAGAAAAAGAAATAGATTTCGTTCCAGCATTT
TATAAAATATTTGATGAAATTATAGTCAATGCTGCAGATAACTTTTAAAGAAATTAAGAT
GGAGCTCCTATGGATACAATAAAAGTTATGATTGATCAATAAAATCAAATGATCTCAGTT
TGGAATAATGGACAAGGAATCCCTATATAAATTCATAAAGAGCATAATATTTATATTCCA
GAAATGATTTTTGGTCATCTATTAACAAGCTCTAATTACGATGATAAAGAAGAGAAAGTA
GTAGGCGGTCGTAATGGATTTGGTGCTAAATTAACAAATATTTTTTCTAAAAAATTCATT
GTTGAATGCAATGATGACAAGCGTAAAAAATATTACAAGTAAGAATGGCGTAAAAATATG
TCTGAAAGAACAGAGCCTTTGATTACAGAAAATAAAAAAGGTGGTAATTTCACATGTGTA
ACATTCTATCCTGACCTTTCTAAATTCAAGATGCAAAATATTTCTGATGATATGGCAAAT
TTACTAAGAAAAAGAGTTTATGATATGGCTGGTATTTTTAACAATAAGGTCAAAGTTTAT
TTGAATAATGAACAAATAAAAATAAAATCCTTTAGTTAATATGTTAACTTGTTTATACCT
GACATTGAAGAACAATACAAATGCTATGATCCAACTATGACTTCTGACAGATGGGAGATT
TTAGTTACTTTTTCAGATGGTTAATTTAAGTAAGTATCGTTTGTAAATGGTATTTGCACA
TCTAGAGGTGGTAAGCATGTAGATTTTGTCATTGATAAAATTGTTGAGAGAATGCAAGAA
TAAATCTTGAAAAAGAATAAAGATCTTGATATCAAGCCTCATTAAATCAAACAAAATTTA
TTCATATTTATGAATTGCCTTATTGTTAACCCTTCGTTTGATTCTCAAACCAAAGACACT
CTTACAACAAAAGCCTCAGCTTTTGGATCAAAACCTGAATTATCAGAAAAATTTATCAAA
AAAATATTGGGTACTGGTATCATTGAGTAAATTGTTTCCTAAGCTAAAGCTCGTCAGAAT
GCTAAATTAGCAAAAACTTTAAAGGGTGGGAAAAAAGGAAGAATTACAGGTATCCCAAAA
CTTGATGATGCTAATGATGCAGGAACAGCAAGAAGTGAAAACTGTACATTAATCTTAACC
GAAGGAGATTCAGCTAAAGCATTAGCAATGGCTGGTATAGAAGTTGTAGGTAGGGATAAT
TATGGTGTATTCCCATTAAAGGGTAAGCTACTTAATGTTAGAGAAGCAAATAAGAAATAG
ATCATCGAAAACCAAGAAATATAAAATATATGCAAAATCATAGGGCTAGATCCTGCTGTT
TAAAACTATGAAAATACAAAGCAATTAAGGTACGGATCTTTAATGATCATGGCTGATTAG
GATAGTGATGGTTCCCATATTAAAGGTTTGGTCATAAACTTTATTCATCACTTCTGGCCT
TCTCTGTTTAAAATGAAAGGGTTTTTAAAAGAATTTATTACTCCCATCCTTAAAGTTACA
AAAGGAGATGAAGTTCATTCATTCTTTACAATATAAGATTTCAAAAATTTTGCTGCTTAA
AAAGGAGACCGCCTTAAGTAATACAAAGTTAAGTACTACAAAGGTCTTGGTACTTCGACT
GACAAAGAAGCTAAAGAATATTTCTCCAATTTCTATAAGCATCAAATTAATTTTTAATAT
TTAGATGAAAACGATATGGAAGCTATTGAATTAGGTTTTTCAGGTAAAAAAATAAAAGAA
CGTAAGGACTGGCTAGCTAATTATGATCCTAATTCATTTGTTGATTATAATATAAAATAA
TTAAGATACAAGGATTTTATTGATAGAGAGCTTATTCACTTCTCAAATGCTGATAATTTA
AGATCTATCCCATCGTTATGTGATGGCCTAAAGCCTGGTCAAAGAAAAATTCTATTTTCT
TGTTTTAAAAGAAATTTAAAATCAGAAATCAAAGTAGCTTAATTAATTGGTTATGTTGCT
GAGCACTCTGCATATCACCACGGTGAATAATCACTCGCTTCAACTATCATCGGAATGGCA
TAAAATTTTGTAGGTTCTAATAATATAAATCTTATGATGCCTATTGGTTAGTTTGGTACA
CGTAATCAAGGTGGAAAAGAGCATGCCTCTGCAAGATACATTTTTACAAGTCTGAGCAAA
ATTACTAGAATACTTTTTCCAGAGCATGATGATCATGTACTGAAGTATTTAGAAGACGAT
AATCAAGTAGTAGAACCAGAATGGTACATGCCAATTATTCCTATGTGTTTAGTAAATGGT
AGTAGTGGTATTGGTACTGGTTGGTCAACTGATATTCCTAACTATAATCACAAGGAAATT
GTTGAATAAATTAGAGGGAAGCTGGAAGGAAAGCCATTTACTGAATTACATCCTTGGTAC
AAAGGATTTTAAGGTTAAATAGAAATTAATCCTAAAGGTGGGTATATAGTCAAAGGGTAA
TACGAAATCGATGAAGTTGAAGAAACAATAAAAATTACTGAATTACCTGTTGGTAAATGG
ACAAGAGACTATAAGAATTATTTAGAAGAGCTACTATCACCACCAAAAGGAGAACCTGAA
ATTGAAGACATTCGTGAATATCATACAAATAATAGAGTTCATTTTGAAGTACAAGCAATA
CCAGGGAGAATATAATAATGGGGTGACATTGAGAAAAAGCTTAAATTAAGCACAACAATG
CAAACAACTAATATAGTTATGTTTAATGATAAATATAAATTAAAAAGATATCAAAGTACT
GTAGAAATAATGGAAGAATTTTATGCTTTACGTCTCAAATGCTACTAAAAAAGAAAAGAT
TATTTAGTCAGCAAAATTCAAAGAGATGTTGATATTTTATAAAATAAGATGAAATTTATT
ACATTAGTTGTCAATGGTACTTTGGAAATTAGAAATGCCAGAAAGAAAGGAGTTCTGAAT
AAACTTAAGGAGTTAGGTCTGACTCCAATGTCAAAAATAACCAGAATCAATTCGACAAAA
ATCTAGGCATTTGAAGAAAAAAAGAAAGAAAGTTAAGCTGAAAAAAATGAAGATAATGAA
GATGAAGAAGTTTAATAAGACGAAGAGGAAGAAGAAGAATAAGTTTAAGAAGGAGAAATT
CCTTTATCTGAATACAACTACCTTCTCTCTATGCCTATCTTTTCTTTGACAGAAGAAAAG
GTATTATAACTCAAAAAATAAGTAGAAGAAAAGGAAAGTGAACTTTTGATCTTATAAAAG
AAAGAAATAAAAGATATGTGGACAGAAGATTTAGATAAATTCATAGAAGTTATTGAATAA
GTAGAAGAAAAAGAAGAAAAAGAGAGACTTACAGGTAAAGGGTTTACATAGAATGGCAAA
GCCCGTGCTAAAAAGAAAAATAACAATAAAGAAAAAGAATAAAAAAAATAATAAAATAAC
TCTTCAGATGACGAAAGCGAAAAGAAAACTGTTGTAAAAAATAAAAATCCATAAAAATCT
GATAATGAAAAATAAAAGCCAAAAGAAAATAATGATAAATAAAAGAAAATAGATGAAAGT
TTTCTTGTGAAGAAAAAAATGGATGCAGAACAATAAAAAACAGAAGAAAAGGTATAAAAG
AAAGAATAGAAGAAAGAGCCAATGAAGTAGCTCTCACTGATTGAAAGAATATCTTAAAAA
TATAGTAATCAGGCGGAATAATAAGTAACGGCAGATATACTTGACACAAATAAACGTAAA
AAAGATCCATCTTCAACTTCTACCTCTGTTTATTCAATGGATATGCCATAATAAAACCTA
AAGCGAAAGAAAAATAATAAATTGAAAGAAGATGATGATGATTTTGACCTTGATTTAGAT
TTCTTAGAACCTAGTTAGATAATTATGAATCCTAGCTAAGATCCTAATAAAAGAACCTTA
AGGTCAAATGGGAAGAAGCCAAGAACGATTTATAAACTAGATTCGGATTCTGATAATGAT
GAATTCAATCAGTAAAATGATGAATCTGATGAAGAAGAGGAAGAGGAATTTGTTATGATG
CCTTCTAAGAGCAATAAGAAAAAATTATTTGATGAGGATGAGGATGATTGA

>TTHERM_00825440(gene)
ATGAGCAAGCAGGAAAAATCAGTAGAAGAAAGATATTAAAAAAAATCCCAAATTGAGCAT
ATTCTTCTTCGTCCTGACTCTTATGTTGGGTCTATAGAAAATGAATAAAAGGTAAACTAT
AATTTGTTTATTTATTGAATACAACTTAGATAGCTTATATTAAATTTAATATAAAATAGT
CATTATGGATTCTAAACAAGGAGGGAACAGCATTAGAAGAAAAAGAAATAGATTTCGTTC
CAGCATTTTATAAAATATTTGATGAAATTATAGTCAATGCTGCAGATAACTTTTAAAGAA
ATTAAGATGGAGCTCCTATGGATACAATAAAAGTTATGATTGATCAATAAAATCAAATGA
TCTCAGTTTGGAATAATGGACAAGGAATCCCTATATAAATTCATAAAGAGCATAATATTT
ATATTCCAGAAATGATTTTTGGTCATCTATTAACAAGCTCTAATTACGATGATAAAGAAG
AGAAAGTAGTAGGCGGTCGTAATGGATTTGGTGCTAAATTAACAAATATTTTTTCTAAAA
AATTCATTGTTGAATGCAATGATGACAAGCGTAAAAAGTAAAATTTAACTAAAATCTATA
ATTTCTTATCCATTTAAATTTAACTTTAGATATTACAAGTAAGAATGGCGTAAAAATATG
TCTGAAAGAACAGAGCCTTTGATTACAGAAAATAAAAAAGGTGGTAATTTCACATGTGTA
ACATTCTATCCTGACCTTTCTAAATTCAAGATGCAAAATATTTCTGATGATATGGCAAAT
TTACTAAGAAAAAGAGTTTATGATATGGCTGGTATTTTTAACAATAAGGTCAAAGTTTAT
TTGAATAATGAACAAATAAAAATAAAATCCTTTAGTTAATATGTTAACTTGTTTATACCT
GACATTGAAGGTAGCTATTTCTTTTTTATTTAAGAAAATGAATTTGCAATGATGATAAAA
TCTAAATGACAGAAAAATACATACTTATAATGGTAATATATGGTAAAACCATATATTGCT
AGTATGTACTTTCATTGTATGATGGCTTACACTTGATTTTGAGCAAATTCATTTTTTTAA
AATTATTTTTAATTAATTAAATTACTTTTTAAATCAAGAAAATTAAAAATTATTTTTTTA
GAACAATACAAATGCTATGATCCAACTATGACTTCTGACAGATGGGAGATTTTAGTTACT
TTTTCAGATGGTTAATTTAAGTAAGTATCGTTTGTAAATGGTATTTGCACATCTAGAGGT
GGTAAGCATGTAGATTTTGTCATTGATAAAATTGTTGAGAGAATGCAAGAATAAATCTTG
AAAAAGAATAAAGATCTTGATATCAAGCCTCATTAAATCAAACAAAATTTATTCATATTT
ATGAATTGCCTTATTGTTAACCCTTCGTTTGATTCTCAAACCAAAGACACTCTTACAACA
AAAGCCTCAGCTTTTGGATCAAAACCTGAATTATCAGAAAAATTTATCAAAAAAATATTG
GGTACTGGTATCATTGAGTAAATTGTTTCCTAAGCTAAAGCTCGTCAGAATGCTAAATTA
GCAAAAACTTTAAAGGGTGGGAAAAAAGGAAGAATTACAGGTATCCCAAAACTTGATGAT
GCTAATGATGCAGGTATTATTTTATAATTTATGAATAATATCATAAAAATACTGATTTAA
AATATAGGAACAGCAAGAAGTGAAAACTGTACATTAATCTTAACCGAAGGAGATTCAGCT
AAAGCATTAGCAATGGCTGGTATAGAAGTTGTAGGTAGGGATAATTATGGTGTATTCCCA
TTAAAGGGTAAGCTACTTAATGTTAGAGAAGCAAATAAGAAATAGATCATCGAAAACCAA
GAAATATAAAATATATGCAAAATCATAGGGCTAGATCCTGCTGTTTAAAACTATGAAAAT
GTATTTATTTTTTATTATTAAATATTATGCATTTAACTTAACATATATTTTAACAGACAA
AGCAATTAAGGTACGGATCTTTAATGATCATGGCTGATTAGGATAGTGATGGTTCCCATA
TTAAAGGTTTGGTCATAAACTTTATTCATCACTTCTGGCCTTCTCTGTTTAAAATGAAAG
GGTTTTTAAAAGAATTTATTACTCCCATCCTTAAAGTTACAAAAGGAGATGAAGTTCATT
CATTCTTTACAATATAAGATTTCAAAAATTTTGCTGCTTAAAAAGGAGACCGCCTTAAGT
AATACAAAGTTAAGTACTACAAAGGTCTTGGTACTTCGACTGACAAAGAAGCTAAAGAAT
ATTTCTCCAATTTCTATAAGCATCAAATTAATTTTTAATATTTAGATGAAAACGATATGG
AAGCTATTGAATTAGGTTTTTCAGGTAAAAAAATAAAAGAACGTAAGGACTGGCTAGCTA
ATTATGATCCTAATTCATTTGTTGATTATAATATAAAATAATTAAGATACAAGGATTTTA
TTGATAGAGAGCTTATTCACTTCTCAAATGCTGATAATTTAAGATCTATCCCATCGTTAT
GTGATGGCCTAAAGCCTGGTCAAAGAAAAATTCTATTTTCTTGTTTTAAAAGAAATTTAA
AATCAGAAATCAAAGTAACCAGAATAAAAAAATAAATTACTTATTAATTTTTCACTTTAA
TTAAAAAGGTAGCTTAATTAATTGGTTATGTTGCTGAGCACTCTGCATATCACCACGGTG
AATAATCACTCGCTTCAACTATCATCGGAATGGCATAAAATTTTGTAGGTTCTAATAATA
TAAATCTTATGATGCCTATTGGTTAGTTTGGTACACGTAATCAAGGTGGAAAAGAGCATG
CCTCTGCAAGATACATTTTTACAAGTCTGAGCAAAATTACTAGAATACTTTTTCCAGAGC
ATGATGATCATGTACTGAAGTATTTAGAAGACGATAATCAAGTAGTAGAACCAGAATGGT
ATTCATTGAATTTTAACTAACTTTAGAATTAATTTATTTTTAAAAATATAAAGGTACATG
CCAATTATTCCTATGTGTTTAGTAAATGGTAGTAGTGGTATTGGTACTGGTTGGTCAACT
GATATTCCTAACTATAATCACAAGGAAATTGTTGAATAAATTAGAGGGAAGCTGGAAGGA
AAGCCATTTACTGAATTACATCCTTGGTACAAAGGATTTTAAGGTTAAATAGAAATTAAT
CCTAAAGGTGGGTATATAGTCAAAGGGTAATACGAAATCGATGAAGTTGAAGAAACAATA
AAAATTACTGAATTACCTGTTGGTAAATGGACAAGAGACTATAAGGTAGTTTTAATTTGT
TAATTTATTAATGGAGTAAATATAATTAAATTTTTATAAAAGAATTATTTAGAAGAGCTA
CTATCACCACCAAAAGGAGAACCTGAAATTGAAGACATTCGTGAATATCATACAAATAAT
AGAGTTCATTTTGAAGTACAAGCAATACCAGGGAGAATATAATAATGGGGTGACATTGAG
AAAAAGCTTAAATTAAGCACAACAATGCAAACAACTAATATAGTTATGTTTAATGATAAA
TATAAATTAAAAAGATATCAAAGTACTGTAGAAATAATGGAAGAATTTTATGCTTTACGT
CTCAAATGCTACTAAAAAAGAAAAGATTATTTAGTCAGCAAAATTCAAAGAGATGTTGAT
ATTTTATAAAATAAGATGAAATTTATTACATTAGTTGTCAATGGTACTTTGGAAATTAGA
AATGCCAGAAAGAAAGGAGTTCTGAATAAACTTAAGGAGTTAGGTCTGACTCCAATGTCA
AAAATAACCAGAATCAATTCGACAAAAATCTAGGTAAATAAAATTTAAATTTGAAAAAAT
ATTAAAATAAATTTTACAAAAAAACAAAGGCATTTGAAGAAAAAAAGAAAGAAAGTTAAG
CTGAAAAAAATGAAGATAATGAAGATGAAGAAGTTTAATAAGACGAAGAGGAAGAAGAAG
AATAAGTTTAAGAAGGAGAAATTCCTTTATCTGAATACAACTACCTTCTCTCTATGCCTA
TCTTTTCTTTGACAGAAGAAAAGGTAATATTCTTTTTTATTAAATTAAAAAAATCAAGTT
AAAAATTAATATAGGTATTATAACTCAAAAAATAAGTAGAAGAAAAGGAAAGTGAACTTT
TGATCTTATAAAAGAAAGAAATAAAAGATATGTGGACAGAAGATTTAGATAAATTCATAG
AAGTAATACAATTTTAGAATTAATTTTAGATAAAGATTTTTAATAAATAATTTATAGGTT
ATTGAATAAGTAGAAGAAAAAGAAGAAAAAGAGAGACTTACAGGTAAAGGGTTTACATAG
AATGGCAAAGCCCGTGCTAAAAAGAAAAATAACAATAAAGAAAAAGAATAAAAAAAATAA
TAAAATAACTCTTCAGATGACGAAAGCGAAAAGAAAACTGTTGTAAAAAATAAAAATCCA
TAAAAATCTGATAATGAAAAATAAAAGCCAAAAGAAAATAATGATAAATAAAAGAAAATA
GATGAAAGTTTTCTTGTGAAGAAAAAAATGGATGCAGAACAATAAAAAACAGAAGAAAAG
GTATAAAAGAAAGAATAGAAGAAAGAGCCAATGAAGTAGCTCTCACTGATTGAAAGAATA
TCTTAAAAATATAGTAATCAGGCGGAATAATAAGTAACGGCAGATATACTTGACACAAAT
AAACGTAAAAAAGATCCATCTTCAACTTCTACCTCTGTTTATTCAATGGATATGCCATAA
TAAAACCTAAAGGTAATTTAATTTAAATTTTTTATTTTTTTTGACATATTTCTTTTTTCT
AGCGAAAGAAAAATAATAAATTGAAAGAAGATGATGATGATTTTGACCTTGATTTAGATT
TCTTAGAACCTAGTTAGATAATTATGAATCCTAGCTAAGATCCTAATAAAAGAACCTTAA
GGTCAAATGGGAAGAAGCCAAGAACGATTTATAAACTAGATTCGGATTCTGATAATGATG
AATTCAATCAGTAAAATGATGAATCTGATGAAGAAGAGGAAGAGGAATTTGTTATGATGC
CTTCTAAGAGCAATAAGAAAAAATTATTTGATGAGGATGAGGATGATTGA

>TTHERM_00825440(protein)
MSKQEKSVEERYQKKSQIEHILLRPDSYVGSIENEQKSLWILNKEGTALEEKEIDFVPAF
YKIFDEIIVNAADNFQRNQDGAPMDTIKVMIDQQNQMISVWNNGQGIPIQIHKEHNIYIP
EMIFGHLLTSSNYDDKEEKVVGGRNGFGAKLTNIFSKKFIVECNDDKRKKYYKQEWRKNM
SERTEPLITENKKGGNFTCVTFYPDLSKFKMQNISDDMANLLRKRVYDMAGIFNNKVKVY
LNNEQIKIKSFSQYVNLFIPDIEEQYKCYDPTMTSDRWEILVTFSDGQFKQVSFVNGICT
SRGGKHVDFVIDKIVERMQEQILKKNKDLDIKPHQIKQNLFIFMNCLIVNPSFDSQTKDT
LTTKASAFGSKPELSEKFIKKILGTGIIEQIVSQAKARQNAKLAKTLKGGKKGRITGIPK
LDDANDAGTARSENCTLILTEGDSAKALAMAGIEVVGRDNYGVFPLKGKLLNVREANKKQ
IIENQEIQNICKIIGLDPAVQNYENTKQLRYGSLMIMADQDSDGSHIKGLVINFIHHFWP
SLFKMKGFLKEFITPILKVTKGDEVHSFFTIQDFKNFAAQKGDRLKQYKVKYYKGLGTST
DKEAKEYFSNFYKHQINFQYLDENDMEAIELGFSGKKIKERKDWLANYDPNSFVDYNIKQ
LRYKDFIDRELIHFSNADNLRSIPSLCDGLKPGQRKILFSCFKRNLKSEIKVAQLIGYVA
EHSAYHHGEQSLASTIIGMAQNFVGSNNINLMMPIGQFGTRNQGGKEHASARYIFTSLSK
ITRILFPEHDDHVLKYLEDDNQVVEPEWYMPIIPMCLVNGSSGIGTGWSTDIPNYNHKEI
VEQIRGKLEGKPFTELHPWYKGFQGQIEINPKGGYIVKGQYEIDEVEETIKITELPVGKW
TRDYKNYLEELLSPPKGEPEIEDIREYHTNNRVHFEVQAIPGRIQQWGDIEKKLKLSTTM
QTTNIVMFNDKYKLKRYQSTVEIMEEFYALRLKCYQKRKDYLVSKIQRDVDILQNKMKFI
TLVVNGTLEIRNARKKGVLNKLKELGLTPMSKITRINSTKIQAFEEKKKESQAEKNEDNE
DEEVQQDEEEEEEQVQEGEIPLSEYNYLLSMPIFSLTEEKVLQLKKQVEEKESELLILQK
KEIKDMWTEDLDKFIEVIEQVEEKEEKERLTGKGFTQNGKARAKKKNNNKEKEQKKQQNN
SSDDESEKKTVVKNKNPQKSDNEKQKPKENNDKQKKIDESFLVKKKMDAEQQKTEEKVQK
KEQKKEPMKQLSLIERISQKYSNQAEQQVTADILDTNKRKKDPSSTSTSVYSMDMPQQNL
KRKKNNKLKEDDDDFDLDLDFLEPSQIIMNPSQDPNKRTLRSNGKKPRTIYKLDSDSDND
EFNQQNDESDEEEEEEFVMMPSKSNKKKLFDEDEDD