Identifiers and Description

Gene Model Identifier

TTHERM_00833740

Standard Name

THD18 (Tetrahymena Histone Deacetylase 18)

Aliases

PreTt14157 | 144.m00120

Description

THD18 SIR2 family transcriptional regulator; transcriptional regulator- Sir2 family protein

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (IEA) | GO:0016811
• NAD+ binding (IEA) | GO:0070403
• zinc ion binding (IEA) | GO:0008270

Biological Process

• chromatin silencing (IEA) | GO:0006342
• protein deacetylation (IEA) | GO:0006476
• regulation of transcription (IEA) | GO:0045449

Domains

• ( PF02146 ) transcriptional regulator, Sir2 family

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_10210.1	9.997093137033517e-262
	Description: transcriptional regulator, Sir2 family protein (1549 aa)
Oxytricha	Contig21344.0.g34	1.9991517704232713e-32
	Description: Sir2 family
Stentor Coeruleus	SteCoe_30793	0.0000000000002543665647376923
	Description: None
DictyBase	DDB_G0270928	0.00000000019994075865167896
	Description: sir2E on chromosome: 1 position 3398987 to 3400602
SGD	YDR191W	0.0000000400154582995175
	Description: HST4 Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
WormBase	WBGene00004802	0.0000029996948234116693
	Description: locus:sir-2.3 NAD-dependent protein deacetylase sir-2.3 status:Partially_confirmed UniProt:Q20481 protein_id:CAA90547.1

General Information

No Data fetched for General Information

Associated Literature

1. Ref:18178773: Smith JJ, Torigoe SE, Maxson J, Fish LC, Wiley EA (2008) A class II histone deacetylase acts on newly synthesized histones in Tetrahymena. Eukaryotic cell 7(3):471-82

Sequences

>TTHERM_00833740(coding)
ATGGAATAAACTGATAATAGCAGCAAACAAACTTAGCAATAAGAAGAAACGAAAGATTGT
AGAAACTGCTCTTATGAAGAAACCATGAAAACGATTGAAGAGACAAGACTAAATTGTTAA
AGGACAATGCAAATTTGCAACTAATCAATATAAACTATTGGAGAATCTATCAAAACAGCC
AATGAAGCAAAATAAAATATCGATGGCTTTTTCGATTAGTACAATTAAGCTATGAACAGC
TTGAGCGAGAAAATTTCTGGATCGTTCTCAGGAATGAGTCGTTGTTTTTTAAAAAATGAG
AACACTGATAAGTAATTTGAAGATTCAAGATAAATAACAGTTAAAGAAGGTGCATAATTT
TTCAAAGACAAGAAAAAAGTTGTTTTTTTGACAGGAGCTGGTATTTCAGTAGCAAGTGGA
ATTCCAACATTCAAAGGAGTTGGTGCTGCACCTCTTTTTGAAAAGGACGGAGTTACTTAT
CAAAATGAACAAATTTCTACTTATAATTTTATGAAAAACAAACCAGATATTTTTTGGGAA
AGAAATTTGATATTCTTAGGAGGTTAATTGGGAAAGAAATACAATGTATCTCACTTAAAG
ATTCAATAATTAGTCAATTAGTATAAATAAATCAAGACATCTTAACTTGGGAAGCAAAAT
GCTTATCAACCCTAAGCAGTAATTGTGACATAAAATACAGATGGTCTTCATTGCTAAGCT
TTTAATGAGTTAAATCCCAGAGAAACAAATTACATGAACAAAGATGATCCTCAATATGGA
TTTTGCCCTGATGTCTTTGAAGTTCATGGCAGTAAAACTTTCCTTAGATGTGATAATTAA
GAATGCAAAGATTATGACAAAAAGTTTTTGTACCCACAAAAATATGATTCTTACAAAGAC
TTCATTTGCGAAACTTGTAAAACCTAAGCTAGACCAAATGTATTGTACTTTGATGAATCT
TATGATGAAAAAAATTATAGGATAAACACTTTGAATGAATTAACTTCTGACATGGATCTA
TTGATATCTATAGGAACATAATTAGACACAGGATATGCTGCTTAAACTGTCAGTAATGCA
GTTCAATAAAAGATTCCAGTCATAGAAATATCTTTAACACCTGTCATATAAAAAGGAGGT
CTAACTCTGAAAGGAAAAGCAGAAGAAGTTGTACCTCAATTATGTGATTTAGTTATGGAA
TTAAATAAATAATTATTACCCACACAACAAAAAGTAGCAAATAAATCAATTGCTTAGAAA
AGTTAAAATCTACTAAAAGATTAAAATAATAAAAGCAATAGCTGTTTATAATCTACAAAT
ACCAGTAAATCTTCCATTTCTAATAAAGTATCAACTAATTCTGCTTAATCTGCAGTAAAA
ACTCTTAATTAAAACCAAGATAATACCTAAACTAATTAAAAACCATAAGTAAAATAAGTC
AGTTTTAGAAAGCCAAATATTAAAGTTGGTCTAAACACAAAGGTAAAAAAGTGA

>TTHERM_00833740(gene)
ATGGAATAAACTGATAATAGCAGCAAACAAACTTAGCAATAAGAAGAAACGAAAGATTGT
AGAAACTGCTCTTATGAAGAAACCATGAAAACGATTGAAGAGACAAGACTAAATTGTTAA
AGGACAATGCAAATTTGCAACTAATCAATATAAACTATTGGAGAATCTATCAAAACAGCC
AATGAAGCAAAATAAAATATCGATGGCTTTTTCGATTAGTACAATTAAGCTATGAACAGC
TTGAGCGAGAAAATTTCTGGATCGTTCTCAGGAATGAGTCGTTGTTTTTTGTAAGTAAAT
CATTCGCTTATTTAAACAACTAAATTTTTTTTTTTAACCAAAAAGAAAAAATGAGAACAC
TGATAAGTAATTTGAAGATTCAAGATAAATAACAGTTAAAGAAGGTGCATAATTTTTCAA
AGACAAGAAAAAAGTTGTTTTTTTGACAGGAGCTGGTATTTCAGTAGCAAGTGGAATTCC
AACATTCAAAGGAGTTGGTGCTGCACCTCTTTTTGAAAAGGACGGAGTTACTTATCAAAA
TGAACAAATTTCTACTTATAATTTTATGAAAAACAAACCAGATATTTTTTGGGAAAGAAA
TTTGATATTCTTAGGAGGTTAATTGGGAAAGAAATACAATGTATCTCACTTAAAGATTCA
ATAATTAGTCAATTAGTATAAATAAATCAAGACATCTTAACTTGGGAAGCAAAATGCTTA
TCAACCCTAAGCAGTAATTGTGACATAAAATACAGATGGTCTTCATTGCTAAGCTTTTAA
TGAGTTAAATCCCAGAGAAACAAATTACATGAACAAAGATGATCCTCAATATGGATTTTG
CCCTGATGTCTTTGAAGTTCATGGCAGTAAAACTTTCCTTAGATGTGATAATTAAGAATG
CAAAGATTATGACAAAAAGTTTTTGTACCCACAAAAATATGATTCTTACAAAGACTTCAT
TTGCGAAACTTGTAAAACCTAAGCTAGACCAAATGTATTGTACTTTGATGAATCTTATGA
TGAAAAAAATTATAGGATAAACACTTTGAATGAATTAACTTCTGACATGGATCTATTGAT
ATCTATAGGAACATAATTAGACACAGGATATGCTGCTTAAACTGTCAGTAATGCAGTTCA
ATAAAAGATTCCAGTCATAGAAATATCTTTAACACCTGTCATATAAAAAGGAGGTCTAAC
TCTGAAAGGAAAAGCAGAAGAAGTTGTACCTCAATTATGTGATTTAGTTATGGAATTAAA
TAAATAATTATTACCCACACAACAAAAAGTAGCAAATAAATCAATTGCTTAGAAAAGTTA
AAATCTACTAAAAGATTAAAATAATAAAAGCAATAGCTGTTTATAATCTACAAATACCAG
TAAATCTTCCATTTCTAATAAAGTATCAACTAATTCTGCTTAATCTGCAGTAAAAACTCT
TAATTAAAACCAAGATAATACCTAAACTAATTAAAAACCATAAGTAAAATAAGTCAGTTT
TAGAAAGCCAAATATTAAAGTTGGTCTAAACACAAAGGTAAAAAAGTGA

>TTHERM_00833740(protein)
MEQTDNSSKQTQQQEETKDCRNCSYEETMKTIEETRLNCQRTMQICNQSIQTIGESIKTA
NEAKQNIDGFFDQYNQAMNSLSEKISGSFSGMSRCFLKNENTDKQFEDSRQITVKEGAQF
FKDKKKVVFLTGAGISVASGIPTFKGVGAAPLFEKDGVTYQNEQISTYNFMKNKPDIFWE
RNLIFLGGQLGKKYNVSHLKIQQLVNQYKQIKTSQLGKQNAYQPQAVIVTQNTDGLHCQA
FNELNPRETNYMNKDDPQYGFCPDVFEVHGSKTFLRCDNQECKDYDKKFLYPQKYDSYKD
FICETCKTQARPNVLYFDESYDEKNYRINTLNELTSDMDLLISIGTQLDTGYAAQTVSNA
VQQKIPVIEISLTPVIQKGGLTLKGKAEEVVPQLCDLVMELNKQLLPTQQKVANKSIAQK
SQNLLKDQNNKSNSCLQSTNTSKSSISNKVSTNSAQSAVKTLNQNQDNTQTNQKPQVKQV
SFRKPNIKVGLNTKVKK