Identifiers and Description

Gene Model Identifier

TTHERM_00833750

Standard Name

THD17 (Tetrahymena Histone Deacetylase 17)

Aliases

PreTt14158 | 144.m00121

Description

THD17 predicted protein; Transcriptional regulator; Sir2 family protein

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (IEA) | GO:0016811
• NAD+ binding (IEA) | GO:0070403
• zinc ion binding (IEA) | GO:0008270

Biological Process

• chromatin silencing (IEA) | GO:0006342
• protein deacetylation (IEA) | GO:0006476
• regulation of transcription (IEA) | GO:0045449

Domains

• ( PF02146 ) Sir2 family

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_10210.1	9.997093137033517e-262
	Description: transcriptional regulator, Sir2 family protein (1549 aa)
WormBase	WBGene00004927	9.997093137033517e-262
	Description: locus:snx-1 status:Confirmed UniProt:Q9GYJ9 protein_id:CCD63142.1
Oxytricha	Contig21344.0.g34	9.000751454575209e-33
	Description: Sir2 family
Stentor Coeruleus	SteCoe_30793	0.0000000000002543665647376923
	Description: None
DictyBase	DDB_G0270928	0.00000000006996681903814525
	Description: sir2E on chromosome: 1 position 3398987 to 3400602
WormBase	WBGene00004800	0.000000004999139696582238
	Description: locus:sir-2.1 status:Partially_confirmed UniProt:D3YT50 protein_id:CBK19468.1
SGD	YDR191W	0.00000030014504373857585
	Description: HST4 Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism

General Information

No Data fetched for General Information

Associated Literature

1. Ref:18178773: Smith JJ, Torigoe SE, Maxson J, Fish LC, Wiley EA (2008) A class II histone deacetylase acts on newly synthesized histones in Tetrahymena. Eukaryotic cell 7(3):471-82

Sequences

>TTHERM_00833750(coding)
ATGGAATAAACTGATAATAGCAACAAACAAACTTAGCAATAAGAAGAAACGAAAGATTAT
AGAAACTGCTCTTATGAAGAAGTCATGAAAATGATTGAAGAGACAAGATTGAATTGTTAA
AGGACAATGCAAATTTGCAACTAATCAATTTAAAGTATTGGAGAATCTATCAAAACGGTC
AATGAAGCAAAATAAAATATCGATGGCTTTTTCGATTAGTACAATTAAGCTATGAACAGC
TTGTGCGAGAAAATTGCTGGATCATTCTCAGGAATGAGTCGTTGTTTTTTAAAAAATGAG
AACACTGATAAGGAATTTGAAGATTCAAGATAAATAACAATCTAAGAAGGTGCATAGCTT
TTCAAAGACAAGAAAAAAGTTGTTTTTTTAACAGGAGCTGGCATTTCAGTTGCAAGTGGA
ATTCCAACATTTAGAGGAGTTGGTGCTGCACCTCTATTTGAAAAAGACGGTGTTACCTAT
TAAAATGAAGAAATTTCTACTTACAATTTTATGAAAAACAAACCAGATATTTTTTGGGAA
AGAAATTTGATATTCTTAGGAGGTTAATTGGGAAAGAAGTACAATGTATCTCACTTAAAG
ATTCAATAATTAGTCAATTAGTATAAATAAATCAAGACATCTTAACTTGGGAAGCAAAAT
GCTTATCAACCCTAAGCAGTAATTGTGACATAAAATACAGACGGTCTTCATTGCTAGGCA
TTTAATGAGTTAAATCCCAGAGAAACAAATTACATGAACAAAGATGATCCTCAATATGGA
TTTTGCCCTGATGTATTTGAAGTTCATGGTAGTAAAACTTTCCTTAGATGTGATAATTAA
GAATGCAAAGATTATGATAAAAAGTTTTTGTACCCATAAAAATATAATTCTTACAAAGAC
TTCATATGCGAAACTTGTAAAACTTAAGCTAGACCAAATGTGTTGTACTTTGATGAATCA
TATAATGAAAAAAATTATAGGATAAACACTTTGAAAGAATTAACTTCTGATATGGATCTA
TTGATATCTATAGGAACATAATTAGACACAGGATATGCTGCTTAAACTGTCAGTAGTGCA
GTTCAATAAAAGATTCCAGTCATAGAAATATCTTTAACACCAGTCATATAAAAAGGAGGT
CTAACTCTGAAAGGAAAAGCAGAAGAAGTTGTACCTCAATTATGTGATTTAGTAATGGAG
TTAAATAAATAATATTTGTAAAATAAATAATTACCCACACCACAACAAAAAGTAGCAACT
AAATCAATTGCTTAGAAAAGTTAAAACCCACTAAAAGATTAAAATTATAAAAGTAATAGC
AGTTTACAATCAACGAATACCAGCAACTCTTCCATTTCTACTAAAGTCTCAACTAATTCT
GCTAAACCTGCAGTAAAACCTCTTAATTAAAACCAAGCGAATACTAAAACTAATTAAAAA
CCATAAGTAAAATAAGTCAGTTCTACAAAGCCAAATGTTAAAATTGGTCTAACCACAAAG
GAAAAAAAGTGA

>TTHERM_00833750(gene)
ATGGAATAAACTGATAATAGCAACAAACAAACTTAGCAATAAGAAGAAACGAAAGATTAT
AGAAACTGCTCTTATGAAGAAGTCATGAAAATGATTGAAGAGACAAGATTGAATTGTTAA
AGGACAATGCAAATTTGCAACTAATCAATTTAAAGTATTGGAGAATCTATCAAAACGGTC
AATGAAGCAAAATAAAATATCGATGGCTTTTTCGATTAGTACAATTAAGCTATGAACAGC
TTGTGCGAGAAAATTGCTGGATCATTCTCAGGAATGAGTCGTTGTTTTTTGTAAGTATAT
CATTCACTTATTTAAACAACTAAATAAATTTTTTAAACATTAAAGAAAAAATGAGAACAC
TGATAAGGAATTTGAAGATTCAAGATAAATAACAATCTAAGAAGGTGCATAGCTTTTCAA
AGACAAGAAAAAAGTTGTTTTTTTAACAGGAGCTGGCATTTCAGTTGCAAGTGGAATTCC
AACATTTAGAGGAGTTGGTGCTGCACCTCTATTTGAAAAAGACGGTGTTACCTATTAAAA
TGAAGAAATTTCTACTTACAATTTTATGAAAAACAAACCAGATATTTTTTGGGAAAGAAA
TTTGATATTCTTAGGAGGTTAATTGGGAAAGAAGTACAATGTATCTCACTTAAAGATTCA
ATAATTAGTCAATTAGTATAAATAAATCAAGACATCTTAACTTGGGAAGCAAAATGCTTA
TCAACCCTAAGCAGTAATTGTGACATAAAATACAGACGGTCTTCATTGCTAGGCATTTAA
TGAGTTAAATCCCAGAGAAACAAATTACATGAACAAAGATGATCCTCAATATGGATTTTG
CCCTGATGTATTTGAAGTTCATGGTAGTAAAACTTTCCTTAGATGTGATAATTAAGAATG
CAAAGATTATGATAAAAAGTTTTTGTACCCATAAAAATATAATTCTTACAAAGACTTCAT
ATGCGAAACTTGTAAAACTTAAGCTAGACCAAATGTGTTGTACTTTGATGAATCATATAA
TGAAAAAAATTATAGGATAAACACTTTGAAAGAATTAACTTCTGATATGGATCTATTGAT
ATCTATAGGAACATAATTAGACACAGGATATGCTGCTTAAACTGTCAGTAGTGCAGTTCA
ATAAAAGATTCCAGTCATAGAAATATCTTTAACACCAGTCATATAAAAAGGAGGTCTAAC
TCTGAAAGGAAAAGCAGAAGAAGTTGTACCTCAATTATGTGATTTAGTAATGGAGTTAAA
TAAATAATATTTGTAAAATAAATAATTACCCACACCACAACAAAAAGTAGCAACTAAATC
AATTGCTTAGAAAAGTTAAAACCCACTAAAAGATTAAAATTATAAAAGTAATAGCAGTTT
ACAATCAACGAATACCAGCAACTCTTCCATTTCTACTAAAGTCTCAACTAATTCTGCTAA
ACCTGCAGTAAAACCTCTTAATTAAAACCAAGCGAATACTAAAACTAATTAAAAACCATA
AGTAAAATAAGTCAGTTCTACAAAGCCAAATGTTAAAATTGGTCTAACCACAAAGGAAAA
AAAGTGA

>TTHERM_00833750(protein)
MEQTDNSNKQTQQQEETKDYRNCSYEEVMKMIEETRLNCQRTMQICNQSIQSIGESIKTV
NEAKQNIDGFFDQYNQAMNSLCEKIAGSFSGMSRCFLKNENTDKEFEDSRQITIQEGAQL
FKDKKKVVFLTGAGISVASGIPTFRGVGAAPLFEKDGVTYQNEEISTYNFMKNKPDIFWE
RNLIFLGGQLGKKYNVSHLKIQQLVNQYKQIKTSQLGKQNAYQPQAVIVTQNTDGLHCQA
FNELNPRETNYMNKDDPQYGFCPDVFEVHGSKTFLRCDNQECKDYDKKFLYPQKYNSYKD
FICETCKTQARPNVLYFDESYNEKNYRINTLKELTSDMDLLISIGTQLDTGYAAQTVSSA
VQQKIPVIEISLTPVIQKGGLTLKGKAEEVVPQLCDLVMELNKQYLQNKQLPTPQQKVAT
KSIAQKSQNPLKDQNYKSNSSLQSTNTSNSSISTKVSTNSAKPAVKPLNQNQANTKTNQK
PQVKQVSSTKPNVKIGLTTKEKK