Identifiers and Description

Gene Model Identifier

TTHERM_00859330

Standard Name

THD10 (Tetrahymena Histone Deacetylase 10)

Aliases

PreTt09095 | 152.m00115

Description

THD10 SIR2 family transcriptional regulator; Sir2-like histone deacetylase; homolog of Danio rerio SIRT5

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (IEA) | GO:0016811
• NAD+ binding (IEA) | GO:0070403
• zinc ion binding (IEA) | GO:0008270

Biological Process

• chromatin silencing (IEA) | GO:0006342
• protein deacetylation (IEA) | GO:0006476
• regulation of transcription (IEA) | GO:0045449

Domains

• ( PF02146 ) Sir2 family

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_07219.1	8.997766383757294e-176
	Description: transcriptional regulator, Sir2 family protein (285 aa)
WormBase	WBGene00002189	8.997766383757294e-176
	Description: locus:kin-1 cAMP-dependent protein kinase catalytic subunit status:Confirmed UniProt:P21137 protein_id:CAD45615.1
Oxytricha	Contig5479.0.g78	1.0004460510701209e-64
	Description: Sir2 family
Stentor Coeruleus	SteCoe_21869	3.975449735908647e-31
	Description: None
DictyBase	DDB_G0283917	0.000000000006001570085597868
	Description: sir2A on chromosome: 4 position 1272110 to 1273864
Tetrahymena borealis	EI9_15826.1	0.000000000006001570085597868
	Description: dual specificity phosphatase, catalytic domain-containing protein (313 aa)
WormBase	WBGene00004800	0.00000000009001903211590313
	Description: locus:sir-2.1 status:Partially_confirmed UniProt:D3YT50 protein_id:CBK19468.1
Tetrahymena borealis	EI9_15287.1	0.00000000009001903211590313
	Description: protein kinase domain-containing protein (567 aa)
SGD	YPL015C	0.000000019990673443141236
	Description: HST2 Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro

General Information

No Data fetched for General Information

Associated Literature

1. Ref:18178773: Smith JJ, Torigoe SE, Maxson J, Fish LC, Wiley EA (2008) A class II histone deacetylase acts on newly synthesized histones in Tetrahymena. Eukaryotic cell 7(3):471-82

Sequences

>TTHERM_00859330(coding)
ATGCAAACCAATTTACATCAACTAATTGCTAAAAGAATTCAAAGCGCAAGCTGTCTTATT
ATCACAGCAGGAGCAGGAATGGGTGTAGATTCAGGACTTCCAGATTTTAGGGGGAAAGAA
GGATTTTGGAACAATTACATTCCTTTTAGGAATAAATTCTCTTTCACTGAGTGTGCTAAT
CCATAATTTTTATTAGATCATCCAAATTTATTTTGGGGGTTTTATGGACACAGACTCCAT
TTATATAGAGAAACACAACCTCACAAAGGTTTTGGAATGTTAAAAACTTGGAGTTAAAAT
AAAAAAAGTTTTGTACTCACCTCAAATGTTGATGGACATTTCTAAAAAGCAGGATTTGAT
AATAAGAGTGTTTATGAAGTTCATGGCTCAATTAATTTTATGCAATGCACAAGCTGTTAA
AGAATTTATTCAGCAGATGGATACAATATTATTTATGATATGAATACATTTGAGGCTAAA
GATCCACTTCCTAATTGTAAGAATTGTGTAAATGTTATAGTACGTCCTAATATTTTGATG
TTTGGGGATTACTCTTTTATGTCAGATAGAGTTGAAGAATAAGAAGATAGGTATCTGTAG
TTTAAAAATCAATTAACTACATAAGATAGAATTATTGTTTTAGAATTTGGAGCAGGGGAA
GCTGTTGCAACTATAAGGATGATGGGCGAAGAATTATTCTTAAAATACAAGCATATAACA
TTCATAAGAGTTAATCCAAGAGATGATAATTCTCCTTTTGGTTGGAAGTAATAGTAAAAT
ACAGAAGATAAAGCTTTTTATGCATTAAAATAAGGGGCTCTTGAAGCAATAACATAAATC
TAATAATATATGTTGTGA

>TTHERM_00859330(gene)
ATGCAAACCAATTTACATCAACTAATTGCTAAAAGAATTCAAAGCGCAAGCTGTCTTATT
ATCACAGCAGGAGCAGGAATGGGTGTAGATTCAGGACTTCCAGATTTTAGGGGGAAAGAA
GGTATTAGAATATAATCTCCACAAAATGCATAATATTTTTAGTTACATTTTTTTTTAATT
TTAGGATTTTGGAACAATTACATTCCTTTTAGGAATAAATTCTCTTTCACTGAGTGTGCT
AATCCATAATTTTTATTAGAGTATTTTTATTAGTTAAATGATATATCTACATTTTTATTT
ATTTTGGTATAAACTAGTCATCCAAGTAATCAAATATTAACTAGCATACAATATTTGACT
TTTTCATCATTAAATTGAAGATTTATTTTGGGGGTTTTATGGACACAGACTCCATTTATA
TAGAGAAACACAACCTCACAAAGGTTTTGGAATGTTAAAAACTTGGAGTTAAAATAAAAA
AAGTTTTGTACTCACCTCAAATGTTGATGGACATTTCTAAAAAGCAGGTAAATTTATTAT
TTTATATTACATTATTGAGTTTTTAAGCTATTTTATATGTAAATTTGTTTAAAATAATGA
ATTTTAGGATTTGATAATAAGAGTGTTTATGAAGTTCATGGCTCAATTAATTTTATGCAA
TGCACAAGCTGTTAAAGAATTTATTCAGCAGATGGTAAATATCATTAAAATCTATCTATC
TATAAACCGTAACTGCTTCGATATATCTGAGCCAAGGACACCATTTTTTATTTGACCATT
TCTTTCATTAACAACCTCCCTCCCTCTCGGCTTTAATTTTAAGATGAATTGGAGGAGCAG
AGTTTTTAAGGTATGAATTTTATATCTCTATTTATATCTAAAGGATACAATATTATTTAT
GATATGAATACATTTGAGGCTAAAGATCCACTTCCTAATTGTAAGAATTGTGTAAATGTT
ATAGTACGTCCTAATATTTTGATGTTTGGGGATTACTCTTTTATGTCAGATAGAGTTGAA
GAATAAGAAGATAGGTATCTGTAGTTTAAAAATCAATTAACTACATAGTAATAATTGAAT
AAATTAATATTAAATATTAACTTATGTTTTATTTTTTATTTAAAGAGATAGAATTATTGT
TTTAGAATTTGGAGCAGGGGAAGCTGTTGCAACTATAAGGATGATGGGCGAAGAATTATT
CTTAAAATACAAGTAAAAATAAATAAAACTCAAATTGATATATTTATCTTTTTTAAAATT
TAGGCATATAACATTCATAAGAGTTAATCCAAGAGATGATAATTCTCCTTTTGGTTGGAA
GTAATAGTAAAATACAGAAGATAAAGCTTTTTATGCATTAAAATAAGGGGCTCTTGAAGC
AATAACATAAATCTAATAATATATGTTGTGA

>TTHERM_00859330(protein)
MQTNLHQLIAKRIQSASCLIITAGAGMGVDSGLPDFRGKEGFWNNYIPFRNKFSFTECAN
PQFLLDHPNLFWGFYGHRLHLYRETQPHKGFGMLKTWSQNKKSFVLTSNVDGHFQKAGFD
NKSVYEVHGSINFMQCTSCQRIYSADGYNIIYDMNTFEAKDPLPNCKNCVNVIVRPNILM
FGDYSFMSDRVEEQEDRYLQFKNQLTTQDRIIVLEFGAGEAVATIRMMGEELFLKYKHIT
FIRVNPRDDNSPFGWKQQQNTEDKAFYALKQGALEAITQIQQYML