Identifiers and Description

Gene Model Identifier

TTHERM_00923170

Standard Name

TPA9 (Tetrahymena P-type ATPase )

Aliases

PreTt21196 | 164.m00089

Description

TPA9 cation-transporting ATPase putative; Novel P-type ATPase with undefined ion specificity; shares certain homology to Plasmodium ATPase-1; constitutively expressed; starvation upregulates expression

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• macronucleus (IDA) | GO:0031039

Molecular Function

• ATP binding (ISS) | GO:0005524
• catalytic activity (IEA) | GO:0003824
• P-type ion transporter activity (ISS) | GO:0015662

Biological Process

• metabolic process (IEA) | GO:0008152
• monoatomic ion transport (ISS) | GO:0006811

Domains

• ( PF00122 ) E1-E2 ATPase
• ( PF00690 ) Cation transporter/ATPase, N-terminus
• ( PF00702 ) haloacid dehalogenase-like hydrolase
• ( PF02357 ) Transcription termination factor nusG
• ( TIGR00099 ) Cof-like hydrolase
• ( TIGR01116 ) calcium-translocating P-type ATPase, SERCA-type
• ( TIGR01494 ) ATPase, P-type (transporting), HAD superfamily,
• ( TIGR01512 ) cadmium-translocating P-type ATPase
• ( TIGR01517 ) calcium-translocating P-type ATPase, PMCA-type
• ( TIGR01522 ) calcium-transporting P-type ATPase, PMR1-type
• ( TIGR01524 ) magnesium-translocating P-type ATPase
• ( TIGR01525 ) heavy metal translocating P-type ATPase
• ( TIGR01647 ) plasma-membrane proton-efflux P-type ATPase
• ( TIGR01652 ) phospholipid-translocating P-type ATPase, flippase
• ( TIGR01657 ) P-type ATPase of unknown pump

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_13231.1	9.997093137033517e-262
	Description: E1-E2 ATPase (1120 aa)
Oxytricha	Contig797.1.g89	4.998549705704758e-84
	Description: E1-E2 ATPase
WormBase	WBGene00022010	7.001663834819337e-84
	Description: locus:catp-7 status:Partially_confirmed UniProt:Q86FP2 protein_id:CCD71143.1
WormBase	WBGene00002179	7.001663834819337e-84
	Description: locus:jph-1 status:Confirmed UniProt:Q22667 protein_id:CAA99924.2
DictyBase	DDB_G0284849	5.000996804856152e-78
	Description: DDB_G0284849 on chromosome: 4 position 2557758 to 2561551
SGD	YOR291W	8.002162267243937e-73
	Description: YPK9 Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
Stentor Coeruleus	SteCoe_30916	4.4737793061811207e-38
	Description: None

General Information

No Data fetched for General Information

Associated Literature

1. Ref:11952090: Linder JU, Schultz JE (2002) Guanylyl cyclases in unicellular organisms. Molecular and cellular biochemistry 230(1-2):149-58
2. Ref:10428960: Linder JU, Engel P, Reimer A, Krüger T, Plattner H, Schultz A, Schultz JE (1999) Guanylyl cyclases with the topology of mammalian adenylyl cyclases and an N-terminal P-type ATPase-like domain in Paramecium, Tetrahymena and Plasmodium. The EMBO journal 18(15):4222-32
3. Ref:9124316: Wang S, Takeyasu K (1997) Primary structure and evolution of the ATP-binding domains of the P-type ATPases in Tetrahymena thermophila. The American journal of physiology 272(2 Pt 1):C715-28
4. Ref:9405804: Wang S, Gao D, Penny J, Krishna S, Takeyasu K (1997) P-type ATPases in Tetrahymena. Annals of the New York Academy of Sciences 834( ):158-60

Sequences

>TTHERM_00923170(coding)
ATGAGAGTTAGCTCAATTGAGGCTGAAATGGAAAACCCTATTGACGTAGATAAAACAGAC
GTAGAGGGTGAATTAAAAATTAAATAAGTCACTCTGCTCAGAGAAAATATAGTTAAAAAA
ATCGTCTTTTTCCTTGTTGCTATTTTTTGCTCCGACAGACCTAGCGTTCTAAAGAAAGTA
TTTTATGAAGAAGTATCTAAATAAGAAGAAGCCACCCATGTTTATGTTCTTGCTTCAGAT
TTGACAGATTACATAGAAGAAGCTAGCTTGAAAGAAAACCCCGAAGAAGGAGGAGAAAAG
TCTATTTATTTTGTAAACAGGCTCTAAAAGTACATCTACCACAAAAAGCAAAATAAATTT
AGAGCTATTGAATACTTTATCTAAGGCAAGTCATACTCTGAAATTGCTAATAATAAACCA
CTCGCTACAGGCAGAGTTGATCAATTACTCGCTTACTATGGAAAGAGTGAAATAGAAATC
AATGTACCATCTTTCTTAACTTTAATGTGGAGAGAGTTCAAAAAACCTATTAACTTTTTA
CTTTATTTTGGTATCATAGTTTGGGGTATTGAACAAATGTATGTTTCTACTGCTATTACT
GTTGTTTTTACCACAACTATTAATTCTCTTATTTGCATTTATATTCGCGGTGTCATGTAA
AAGCTAAAGGATGCCTGTCTTAATAACACTTCTGTCATAGTATAAAGACATAATGGCTAA
GGATACTAAGAAATAACAGTAGCATCTAATATGATAGCTCCTGGTGATATAGTTCTCTTC
AAAAGAGAAGTTACTCTCCCTTTTGACTGTGTAATTTTGGAAGGCTCTTGCTAAGTTACT
GAAGCCAATATTACAGGTGAAAACGTTGCAATCGGAAAGTGTCAAATACCTACTGATCAT
CACAATGATATTTTTAAATATGAATCAAGCAAATCTCACACTCTCTTCTAAGGTACTCAA
TTGATGAAGATTGAAGATGATATCTTAAAAGTAATTGTTGTAAGAACTGGTTTTGGAAGC
TACAAGGGTCAAATTATTAGAGCTTTACTTTATCCCAAGCCTTTCAATAAAAAATTCTAA
CAATAAGCTGTCAAGTTAACTATTTTAATGGCTACCCTTTTGCTTATCGGTTTCCTTTCT
ACCCTTTCTAGACTCCTTGATATTGAACTTCCTCCTTTGTTCATAGCTTTTAGATTCTTA
GATATTCTCATCTATAGTGCTCCTCCTGGTATGCCTATGCTTATCGCCATTACAAACTTC
GTTGGCTTGAAAAGATTAAAAAATAATTAGATTTTAGGATAAGATCCTAACTCTGCAAGT
TAAGCTGGTAGAATTTAAACTCTTTGCTTTGATAAGACTGGTACTCTTACTGAAGATAAG
GTTGATTTAATTGGTTACCAATTGAAAGGATAGAATCAAACATTCGATAAGATTCAATGC
TAAGATCCTAACAATATCTCAATTGAACACAAACTCTTTAGTATTTGCCATGAAGTAACA
AAAATTAACAATAAGCTTTTAGGTGATTTAATGGATGTAAAAATGGCTGAATTCAGTACT
CTCGATATAGATTACGACCATGAAGCCAAATAACACTACTCTAAATCAGGTAATAAAAGA
TTCTATTGTATCTAAGTTAACTAATTCCATTCTGAATACCAATCTATGAGTGTTGTTTGC
AAGGAAGTTGATATGATCACCAAGGAATTCAAGCATTACTTCTTCATCAAGGGATCTCCT
GAAAAGATTCAATCCTTGTCACACGTTTAATCTTCAGAAAAAGCTCAATTAAGTACCTTG
ATTAATGAAGGATACAGAATTCTTGGATTTGGTTACAAGGAAATTCCTTAAAGTGAAATA
GATGCCTTTTTAGATTTAAGCAGAGAATAACAAGAAGCCAATGTTTAATCTCTTGGTTTC
CTTATTTATAAGAATAATCTTAAACCTGACACTCAAGAAGTGATCAAAGAATTCAAAGAA
GCATGTTACAATATTAAGGTTATCTCTGGTGATAATCCAATCACTACTTTAAAAATATCC
TAAGAATTAGAAATCGTCAATAGAAAAAATCCAACAGTTATCATCAACTTTGAGGAAACT
GAAAATGTCAAGAGTCATCTTATTATCACTGAAATCTAACCTGATAACTCAACTCAAGTA
ATTGATTTCAGTTCAGCTCAAAATGAATAAGACTACATTAATAAATAAATGAGTTATTGC
TGTGATGCTTTCCTTAATAACAAATCTTTTTGTTTCAGCGGTAAAGCCCATTACTACTTC
TAGCTTAAGGCCAAGACTGACCATATTTCATTCAAGCCTGAATGGGTTAAAATGCAAGAT
AAATCTGTCTAAAAAATAATTTCTTTCTATCAAATGTTGATAATTAACACCAATGTTTTC
GCTAGAACTCAACCTGAATAAAAGCAAACTATTGTTAGACTCTTGAAAGAAAGTGACTAA
ATAGTATGTATGGTTGGTGATGGTGCAAATGACTGCTCCGCTATTCGTGAAGCAGATGTC
GGTATTTCTTTTGCTGAAGCTGATGGTTAATTCTCTTCATCCTATGTATCTTTATCAACT
TCTCTTTCCTGCGTTAAAAGAGTTTTGTTAGAAGGTAGAGTTAATTTATCTAATAGTGTA
GAAATTTTCAAGGGTTACTTACAAGTTGCACTTTTGAGATATTTAGGTTTCTTGACTTTA
GCTTACTTCTACTCATCCTACAGTAGTGGTTAAATGGATTGGTAAGCTTTAGCCTCAGGT
TACTTCTTAGTTTATTTGATATTAGGTTGCAACACACCCTTAAAGAAGCTCGAAAAGAGT
GTTTTCGATGATAACCTTTTCAGCATATATAATGTTACTTCTGTACTTTTTGGATTCACT
TTGCATATTTTGTCTATTGTTGGGTGCGTTGAAAGTCTTCATGCTAGTCCCATTTACAAG
GAAGTAAACAGCTTAGACGCTGAAAATAACTTCTAATTTGAGACTCAACACAATACTGTT
TTGAATTTCAATATTTTGATCAATTTCTTCTATGTGATTATTTCTAACCACATCGGAAAA
CCTATGAAAGATAGATATTATAAGAACACTATTGCCTATCTTATGATTTGGGGTTAATTT
ATACATGCAAATGTTATGATTTTTACAAGTTCTGCTTATCCTGGAGCATACACATCATGG
GTTGATCTTCCTGATACTACTCTTAGATTAAGAATTTTCTTCATCTCTAACGGTTTAGGT
CTACTTCTCCTTGCCTATGAACTTATTTTTGCCAGAAGAATTTTCGTTAAACTTTACACA
AGAAGTCAAGAAAGAAAAAGAGCTGCTCATATGTAATAGCTCATCGACCATATTAGAAGT
TGA

>TTHERM_00923170(gene)
ATGAGAGTTAGCTCAATTGAGGCTGAAATGGAAAACCCTATTGACGTAGATAAAACAGAC
GTAGAGGGTGAATTAAAAATTAAATAAGTCACTCTGCTCAGAGAAAATATAGTTAAAAAA
ATCGTCTTTTTCCTTGTTGCTATTTTTTGCTCCGACAGACCTAGCGTTCTAAAGAAAGTA
TTTTATGAAGAAGTATCTAAATAAGAAGAAGCCACCCATGTTTATGTTCTTGCTTCAGAT
TTGACAGATTACATAGAAGAAGCTAGCTTGAAAGAAAACCCCGAAGAAGGAGGAGAAAAG
TCTATTTATTTTGTAAACAGGCTCTAAAAGTACATCTACCACAAAAAGCAAAATAAATTT
AGAGCTATTGAATACTTTATCTAAGGCAAGTCATACTCTGAAATTGCTAATAATAAACCA
CTCGCTACAGGCAGAGTTGATCAATTGTAATAAAAATATTTCTATTTTTCTATTTCAATT
ACTCGTTATTATTTATAATAAAAAAAATACCTTCATTAAGCAAATATAGAACAGAACAGC
TTCAACGCTTTTCTTTATTAAATTCGAAATGAACAAAAATTTAATTTTATTTTAAATAAA
TTAAAAGACTCGCTTACTATGGAAAGAGTGAAATAGAAATCAATGTACCATCTTTCTTAA
CTTTAATGTGGAGAGAGTTCAAAAAACCTATTAACTTTTTACTTTATTTTGGTATCATAG
TTTGGGGTATTGAACAAATGTATGTTTCTACTGCTATTACTGTTGTTTTTACCACAACTA
TTAATTCTCTTATTTGCATTTATATTCGCGGTGTCATGTAAAAGCTAAAGGATGCCTGTC
TTAATAACACTTCTGTCATAGTATAAAGACATAATGGCTAAGGATACTAAGAAATAACAG
TAGCATCTAATATGATAGCTCCTGGTGATATAGTTCTCTTCAAAAGAGAAGTTACTCTCC
CTTTTGACTGTGTAATTTTGGAAGGCTCTTGCTAAGTTACTGAAGCCAATATTACAGGTA
ATTAATATTCTTTTAATTTTCATATATCTTATGTTTATTAAATAATTAAATTATTATTTT
ACAAAATAGGTGAAAACGTTGCAATCGGAAAGTGTCAAATACCTACTGATCATCACAATG
ATATTTTTAAGTAAAATATTTAATAACTTTAATTCTCAACTAATTATTAAATTAATTTTT
CATAATAAAAATAGATATGAATCAAGCAAATCTCACACTCTCTTCTAAGGTACTCAATTG
ATGAAGATTGAAGATGATATCTTAAAAGTAATTGTTGTAAGAACTGGTTTTGGAAGCTAC
AAGGGTCAAATTATTAGAGCTTTACTTTATCCCAAGCCTTTCAATAAAAAATTCTAACAA
TAAGCTGTCAAGTTAACTATTTTAATGGCTACCCTTTTGCTTATCGGTTTCCTTTCTACC
CTTTCTAGACTCCTTGATATTGAACTTCCTCCTTTGTTCATAGCTTTTAGATTCTTAGAT
ATTCTCATCTATAGTGCTCCTCCTGGTATGCCTATGCTTATCGCCATTACAAACTTCGTT
GGCTTGAAAAGATTAAAAAATAATTAGATTTTAGGATAAGATCCTAACTCTGCAAGTTAA
GCTGGTAGAATTTAAACTCTTTGCTTTGATAAGACTGGTACTCTTACTGAAGATAAGGTT
GATTTAATTGGTTACCAATTGAAAGGATAGAATCAAACATTCGATAAGATTCAATGCTAA
GATCCTAACAATATCTCAATTGAACACAAACTCTTTAGTATTTGCCATGAAGTAACAAAA
ATTAACAATAAGCTTTTAGGTGATTTAATGGATGTAAAAATGGCTGAATTCAGTACTCTC
GATATAGATTACGACCATGAAGCCAAATAACACTACTCTAAATCAGGTAATAAAAGATTC
TATTGTATCTAAGTTAACTAATTCCATTCTGAATACCAATCTATGAGTGTTGTTTGCAAG
GAAGTTGATATGATCACCAAGGAATTCAAGCATTACTTCTTCATCAAGGGATCTCCTGAA
AAGATTCAATCCTTGTCACACGTTTAATCTTCAGAAAAAGCTCAATTAAGTACCTTGATT
AATGAAGGATACAGAATTCTTGGATTTGGTTACAAGGAAATTCCTTAAAGTGAAATAGAT
GCCTTTTTAGATTTAAGCAGAGAATAACAAGAAGCCAATGTTTAATCTCTTGGTTTCCTT
ATTTATAAGAATAATCTTAAACCTGACACTCAAGAAGTGATCAAAGAATTCAAAGAAGCA
TGTTACAATATTAAGGTTATCTCTGGTGATAATCCAATCACTACTTTAAAAATATCCTAA
GAATTAGAAATCGTCAATAGAAAAAATCCAACAGTTATCATCAACTTTGAGGAAACTGAA
AATGTCAAGAGTCATCTTATTATCACTGAAATCTAACCTGATAACTCAACTCAAGTAATT
GATTTCAGTTCAGCTCAAAATGAATAAGACTACATTAATAAATAAATGAGTTATTGCTGT
GATGCTTTCCTTAATAACAAATCTTTTTGTTTCAGCGGTAAAGCCCATTACTACTTCTAG
CTTAAGGCCAAGACTGACCATATTTCATTCAAGCCTGAATGGGTTAAAATGCAAGATAAA
TCTGTCTAAAAAATAATTTCTTTCTATCAAATGTTGATAATTAACACCAATGTTTTCGCT
AGAACTCAACCTGAATAAAAGCAAACTATTGTTAGACTCTTGAAAGAAAGTGACTAAATA
GTATGTATGGTTGGTGATGGTGCAAATGACTGCTCCGCTATTCGTGAAGCAGATGTCGGT
ATTTCTTTTGCTGAAGCTGATGGTTAATTCTCTTCATCCTATGTATCTTTATCAACTTCT
CTTTCCTGCGTTAAAAGAGTTTTGTTAGAAGGTAGAGTTAATTTATCTAATAGTGTAGAA
ATTTTCAAGGGTTACTTACAAGTTGCACTTTTGAGATATTTAGGTTTCTTGACTTTAGCT
TACTTCTACTCATCCTACAGTAGTGGTTAAATGGATTGGTAAGCTTTAGCCTCAGGTTAC
TTCTTAGTTTATTTGATATTAGGTTGCAACACACCCTTAAAGAAGCTCGAAAAGAGTGTT
TTCGATGATAACCTTTTCAGCATATATAATGTTACTTCTGTACTTTTTGGATTCACTTTG
CATATTTTGTCTATTGTTGGGTGCGTTGAAAGTCTTCATGCTAGTCCCATTTACAAGGAA
GTAAACAGCTTAGACGCTGAAAATAACTTCTAATTTGAGACTCAACACAATACTGTTTTG
AATTTCAATATTTTGATCAATTTCTTCTATGTGATTATTTCTAACCACATCGGAAAACCT
ATGAAAGATAGATATTATAAGAACACTATTGCCTATCTTATGATTTGGGGTTAATTTATA
CATGCAAATGTTATGATTTTTACAAGTTCTGCTTATCCTGGAGCATACACATCATGGGTT
GATCTTCCTGATACTACTCTTAGATTAAGAATTTTCTTCATCTCTAACGGTTTAGGTCTA
CTTCTCCTTGCCTATGAACTTATTTTTGCCAGAAGAATTTTCGTTAAACTTTACACAAGA
AGTCAAGAAAGAAAAAGAGCTGCTCATATGTAATAGCTCATCGACCATATTAGAAGTTGA

>TTHERM_00923170(protein)
MRVSSIEAEMENPIDVDKTDVEGELKIKQVTLLRENIVKKIVFFLVAIFCSDRPSVLKKV
FYEEVSKQEEATHVYVLASDLTDYIEEASLKENPEEGGEKSIYFVNRLQKYIYHKKQNKF
RAIEYFIQGKSYSEIANNKPLATGRVDQLLAYYGKSEIEINVPSFLTLMWREFKKPINFL
LYFGIIVWGIEQMYVSTAITVVFTTTINSLICIYIRGVMQKLKDACLNNTSVIVQRHNGQ
GYQEITVASNMIAPGDIVLFKREVTLPFDCVILEGSCQVTEANITGENVAIGKCQIPTDH
HNDIFKYESSKSHTLFQGTQLMKIEDDILKVIVVRTGFGSYKGQIIRALLYPKPFNKKFQ
QQAVKLTILMATLLLIGFLSTLSRLLDIELPPLFIAFRFLDILIYSAPPGMPMLIAITNF
VGLKRLKNNQILGQDPNSASQAGRIQTLCFDKTGTLTEDKVDLIGYQLKGQNQTFDKIQC
QDPNNISIEHKLFSICHEVTKINNKLLGDLMDVKMAEFSTLDIDYDHEAKQHYSKSGNKR
FYCIQVNQFHSEYQSMSVVCKEVDMITKEFKHYFFIKGSPEKIQSLSHVQSSEKAQLSTL
INEGYRILGFGYKEIPQSEIDAFLDLSREQQEANVQSLGFLIYKNNLKPDTQEVIKEFKE
ACYNIKVISGDNPITTLKISQELEIVNRKNPTVIINFEETENVKSHLIITEIQPDNSTQV
IDFSSAQNEQDYINKQMSYCCDAFLNNKSFCFSGKAHYYFQLKAKTDHISFKPEWVKMQD
KSVQKIISFYQMLIINTNVFARTQPEQKQTIVRLLKESDQIVCMVGDGANDCSAIREADV
GISFAEADGQFSSSYVSLSTSLSCVKRVLLEGRVNLSNSVEIFKGYLQVALLRYLGFLTL
AYFYSSYSSGQMDWQALASGYFLVYLILGCNTPLKKLEKSVFDDNLFSIYNVTSVLFGFT
LHILSIVGCVESLHASPIYKEVNSLDAENNFQFETQHNTVLNFNILINFFYVIISNHIGK
PMKDRYYKNTIAYLMIWGQFIHANVMIFTSSAYPGAYTSWVDLPDTTLRLRIFFISNGLG
LLLLAYELIFARRIFVKLYTRSQERKRAAHMQQLIDHIRS