Identifiers and Description

Gene Model Identifier

TTHERM_00961880

Standard Name

EFR2 (Elongation Factor 2 Related 2)

Aliases

PreTt23676 | 178.m00057

Description

EFR2 translation elongation factor EF-2 subunit; Elongation factor 2 related protein; expressed only during conjugation- significant amino acid identity to EF-2 ifrom other eukaryotes but with differences at some residues that are typically post-translational regulation sites

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• GTP binding (IEA) | GO:0005525
• GTPase activity (IEA) | GO:0003924

Biological Process

• translation (ISS) | GO:0006412

Domains

• ( PF00009 ) Elongation factor Tu GTP binding domain
• ( PF00167 ) Fibroblast growth factor
• ( PF00679 ) Elongation factor G C-terminus
• ( PF01926 ) 50S ribosome-binding GTPase
• ( PF03144 ) Elongation factor Tu domain 2
• ( PF03764 ) Elongation factor G, domain IV
• ( PF04644 ) Motilin/ghrelin
• ( PF05705 ) Eukaryotic protein of unknown function (DUF829)
• ( PF08477 ) Ras of Complex, Roc, domain of DAPkinase
• ( TIGR00231 ) small GTP-binding protein domain
• ( TIGR00475 ) selenocysteine-specific translation elongation factor
• ( TIGR00483 ) translation elongation factor EF-1, subunit
• ( TIGR00484 ) translation elongation factor G
• ( TIGR00485 ) translation elongation factor Tu
• ( TIGR00490 ) translation elongation factor aEF-2
• ( TIGR00503 ) peptide chain release factor 3
• ( TIGR01393 ) GTP-binding protein LepA
• ( TIGR01394 ) GTP-binding protein TypA/BipA

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Stentor Coeruleus	SteCoe_7852	0
	Description: None
WormBase	WBGene00001167	9.997093137033517e-262
	Description: locus:eef-2 Elongation factor 2 status:Confirmed UniProt:P29691 protein_id:CAB02985.1
Tetrahymena borealis	EI9_08465.1	9.997093137033517e-262
	Description: elongation factor G, domain IV family protein (842 aa)
DictyBase	DDB_G0287685	9.997093137033517e-262
	Description: cinC on chromosome: 5 position 689907 to 692602
Oxytricha	Contig22552.0.g51	9.997093137033517e-262
	Description: Elongation factor Tu GTP binding domain
SGD	YOR133W	9.997093137033517e-262
	Description: EFT1 Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
WormBase	WBGene00000254	9.997093137033517e-262
	Description: locus:bli-4 Endoprotease bli-4 status:Confirmed UniProt:P51559 protein_id:CCD70038.1

General Information

No Data fetched for General Information

Associated Literature

1. Ref:14729267: Malavé TM, Forney JD (2004) Identification of a developmentally regulated translation elongation factor 2 in Tetrahymena thermophila. Gene 326( ):97-105
2. Ref:12673598: Ueno H, Gonda K, Takeda T, Numata O (2003) Identification of elongation factor-1alpha as a Ca2+/calmodulin-binding protein in Tetrahymena cilia. Cell motility and the cytoskeleton 55(1):51-60

Sequences

>TTHERM_00961880(coding)
ATGAAGACTCTCCAGATTGAGAAGATAAGAGAACTCATGATGAACCCCAATCAAATCAGA
AATATGTCTGTCATAGCCCACGTTGATCATGGTAAGACTACTTTAACTGATTCTTTGTTA
GCTAGAGCTGGTATCATCTCAGAAAGCAACGCTGGTAAAGCCTGCATGATGGATACTGAC
CCAAAAGAACAAAAAATGGGAATCACCATTAAGTCAACTGGAGTTTCCTTATACTATCAA
AATACTGTGACCAAGTAGGAGAGTATCATTAATTTGATTGATTCTCCAGGTCATATTGAC
TTTTCTGGTGAAGTTACTGCTGCATTAAGAGTTACTGATGGAGCTCTTGTTGTGGTAGAT
GCTGTTGAAGGTGTTGCTGTTCAAACAGAAACAGTTCTAAGGCAGGCTTGCCAAGAACGA
ATACGACCCGTTCTTGTAATTAATAAGCTAGACAGACTATTTAGTGAGCTTAAGGATGAT
TATGAAAATATTTATCAAAGATTAGTAGAGATCATAGCAAGGATTAATTCTATCTTGGAA
ATGAACGAAAATGAATCTATTAAAGGCTACACTTTAGATCCCTCACTTGGAAATGTTGCT
TTCTCTTCTGGTAAACAGTGCTGGGGATTCACTTTAAAGACTTTTGCTAGAATTTATAGT
CAAAAATTCTCAACAAAGGAAGAAACTTTAATGACTAAATTATGGGGAGACAACTATTTT
AATCCTCAAACAAAGTAATTCACCTCAGAATTAATCAGTAATAATACCTAAAACAAGTAA
GCTAGTCGTTCATTCATTGAATTCGTTTTAGTTCCTTTAGATAAGTACTATTCAGCCTCT
TCAAATGCAGAAATTGAAACTCTTTCCAAGATGGTTGAAAAGCTCAACCTTTCTTCCATT
CTAACTTCAGCTGAATTAGAAAGACTCAAATAGGTTGATGTTCAAGAGAGAATCAAGAGG
TCTATGAGGGCTTGGTTACCCTTAGCCGATGCCATACTTGAAATGGTCTAAGATCATTTA
CCTTCACCAAAAGAGGCTATGAAATATCGTAGTTTGTATCTTTACGAAGGACCTGCTGGT
GATGAGGCTTGTGCAGCAATGAGAGAATGTAATTCTGAGGGACCTCTCATGGTTTACATT
TCAAAAATGGTTTAAACTGAAGATCTTGGTAGATTTTATGCTTTTGGTAGAGTATTCAGT
GGCACAATATCTCAAGGCATGAAAGTCAGAGTCTAAGGTCCTGACTATAAACCTGGAAGC
AAAGAAGATCTCTTTATCAAAACAATCTAGCATACATTTTTGATGATGGGTAAACAGCAT
GAGCCTATCGAATCAGTACCAGCTGGAGGTACCGTCCTCATCTTAGGTGTTGATAACGCT
CTTACTAAAACAGGAACTCTTACAACTTCAGAAACAGCACATAATATCAGAAACATGAAG
TACACGATTTCACCTATATTGAGAGTTGCTGTCAATACTCCTAACTAACAAGATCTTACA
CGTCTACTTGAAGGTCTTAAGATGCTTCAAAAATATGATCCTCTTGTTCAAGTAGAAGTT
GAAGAAAATACAGGATCCTATGTTGTTGCTGGTAGTGGTGAATTGCATATTAAAATTTGC
TTAGAAAAACTGAATGATTTCACCCACAACTCTATTAATATTGTTGCTTCTCAACCCACT
GTATCTTACAGAGAAACAATAGCTGAAAAGAGCTCTTAAACTTGCCTAGCTAAGACTGAA
AATAAGCTTAATCATCTGTATGGTACTTGCGAACCACTTGATGAAGAATTAGGATCAGCA
ATAGTGAGCAAAAAAATAAATATTAAAGACATTAACAACTAAAAAATGATTAACAGTTTG
GTGAATGATTATTCTTGGGAAAGAGAAGATGCAAAGCGTATATGGTGCTTCGGTCCTCTA
GAAAAGGAGTCCACTAATTGCATCGTAAACCAAACAGTTGGTATATAAGGTATGCCTGCA
ATTCAGCCTTCTATAATAACCGCCTTCGAATGGTGTACTAAGGAAGGTCTTTTGTGTGAT
GAGCCTCTTAGAAATATTCGCTTTAACATAATGGATGTAATAATACACGATGAACCTGCT
CATCACAGAAGCAATCAAATAACCCCAGCAGCTAGAAGGCTATTTAAGGCTTGCTAATAT
GTGAGTGAACCTAAAATTTTGGAACCATTTTATTTATGCAACATTAAAACTCCAGATGAA
AGGAAAGGACCTATATATGCATTCCTCAATAAATTCCTAGATAAGAGAAGAGGTTTAGTT
TTAGGAGAAGAATATGATGATATATTTACCGTGATTCAAGCCTACATCCCTGTATCTGAA
AGCTTTGGATTCGACCAAGCTATAAAGTCAGTCTCCTAAGGTATGGCAATGCCAGCTCTC
TCATTCAGTCACTGGCAAGCAGTCTAGGGTAATCCACTCGACCCAGAATCAGAATCAGGT
AAGATTGTTAATGAAATAAGAATAAGAAAAGGTTTGAATGCTAAAATACCAGAACTCAAC
TATTATCTTGATAAACTTTGA

>TTHERM_00961880(gene)
ATGAAGACTCTCCAGATTGAGAAGATAAGAGAACTCATGATGAACCCCAATCAAATCAGA
AATATGTCTGTCATAGCCCACGTTGATCATGGTAAGACTACTTTAACTGATTCTTTGTTA
GCTAGAGCTGGTATCATCTCAGAAAGCAACGCTGGTAAAGCCTGCATGATGGATACTGAC
CCAAAAGAACAAAAAATGGGAATCACCATTAAGTCAACTGGAGTTTCCTTATACTATCAA
AATACTGTGACCAAGTAGGAGAGTATCATTAATTTGATTGATTCTCCAGGTCATATTGAC
TTTTCTGGTGAAGTTACTGCTGCATTAAGAGTTACTGATGGAGCTCTTGTTGTGGTAGAT
GCTGTTGAAGGTGTTGCTGTTCAAACAGAAACAGTTCTAAGGCAGGCTTGCCAAGAACGA
ATACGACCCGTTCTTGTAATTAATAAGCTAGACAGACTATTTAGTGAGCTTAAGGATGAT
TATGAAAATATTTATCAAAGATTAGTAGAGATCATAGCAAGGATTAATTCTATCTTGGAA
ATGAACGAAAATGAATCTATTAAAGGCTACACTTTAGATCCCTCACTTGGAAATGTTGCT
TTCTCTTCTGGTAAACAGTGCTGGGGATTCACTTTAAAGACTTTTGCTAGAATTTATAGT
CAAAAATTCTCAACAAAGGAAGAAACTTTAATGACTAAATTATGGGGAGACAACTATTTT
AATCCTCAAACAAAGTAATTCACCTCAGAATTAATCAGTAATAATACCTAAAACAAGTAA
GCTAGTCGTTCATTCATTGAATTCGTTTTAGTTCCTTTAGATAAGTACTATTCAGCCTCT
TCAAATGCAGAAATTGAAACTCTTTCCAAGATGGTTGAAAAGCTCAACCTTTCTTCCATT
CTAACTTCAGCTGAATTAGAAAGACTCAAATAGGTTGATGTTCAAGAGAGAATCAAGAGG
TCTATGAGGGCTTGGTTACCCTTAGCCGATGCCATACTTGAAATGGTCTAAGATCATTTA
CCTTCACCAAAAGAGGCTATGAAATATCGTAGTTTGTATCTTTACGAAGGACCTGCTGGT
GATGAGGCTTGTGCAGCAATGAGAGAATGTAATTCTGAGGGACCTCTCATGGTTTACATT
TCAAAAATGGTTTAAACTGAAGATCTTGGTAGATTTTATGCTTTTGGTAGAGTATTCAGT
GGCACAATATCTCAAGGCATGAAAGTCAGAGTCTAAGGTCCTGACTATAAACCTGGAAGC
AAAGAAGATCTCTTTATCAAAACAATCTAGCATACATTTTTGATGATGGGTAAACAGCAT
GAGCCTATCGAATCAGTACCAGCTGGAGGTACCGTCCTCATCTTAGGTGTTGATAACGCT
CTTACTAAAACAGGAACTCTTACAACTTCAGAAACAGCACATAATATCAGAAACATGAAG
TACACGATTTCACCTATATTGAGAGTTGCTGTCAATACTCCTAACTAACAAGATCTTACA
CGTCTACTTGAAGGTCTTAAGATGCTTCAAAAATATGATCCTCTTGTTCAAGTAGAAGTT
GAAGAAAATACAGGATCCTATGTTGTTGCTGGTAGTGGTGAATTGCATATTAAAATTTGC
TTAGAAAAACTGAATGATTTCACCCACAACTCTATTAATATTGTTGCTTCTCAACCCACT
GTATCTTACAGAGAAACAATAGCTGAAAAGAGCTCTTAAACTTGCCTAGCTAAGACTGAA
AATAAGCTTAATCATCTGTATGGTACTTGCGAACCACTTGATGAAGAATTAGGATCAGCA
ATAGTGAGCAAAAAAATAAATATTAAAGACATTAACAACTAAAAAATGATTAACAGTTTG
GTGAATGATTATTCTTGGGAAAGAGAAGATGCAAAGCGTATATGGTGCTTCGGTCCTCTA
GAAAAGGAGTCCACTAATTGCATCGTAAACCAAACAGTTGGTATATAAGGTATGCCTGCA
ATTCAGCCTTCTATAATAACCGCCTTCGAATGGTGTACTAAGGAAGGTCTTTTGTGTGAT
GAGCCTCTTAGAAATATTCGCTTTAACATAATGGATGTAATAATACACGATGAACCTGCT
CATCACAGAAGCAATCAAATAACCCCAGCAGCTAGAAGGCTATTTAAGGCTTGCTAATAT
GTGAGTGAACCTAAAATTTTGGAACCATTTTATTTATGCAACATTAAAACTCCAGATGAA
AGGAAAGGACCTATATATGCATTCCTCAATAAATTCCTAGATAAGAGAAGAGGTTTAGTT
TTAGGAGAAGAATATGATGATATATTTACCGTGATTCAAGCCTACATCCCTGTATCTGAA
AGCTTTGGATTCGACCAAGCTATAAAGTCAGTCTCCTAAGGTATGGCAATGCCAGCTCTC
TCATTCAGTCACTGGCAAGCAGTCTAGGGTAATCCACTCGACCCAGAATCAGAATCAGGT
AAGATTGTTAATGAAATAAGAATAAGAAAAGGTTTGAATGCTAAAATACCAGAACTCAAC
TATTATCTTGATAAACTTTGA

>TTHERM_00961880(protein)
MKTLQIEKIRELMMNPNQIRNMSVIAHVDHGKTTLTDSLLARAGIISESNAGKACMMDTD
PKEQKMGITIKSTGVSLYYQNTVTKQESIINLIDSPGHIDFSGEVTAALRVTDGALVVVD
AVEGVAVQTETVLRQACQERIRPVLVINKLDRLFSELKDDYENIYQRLVEIIARINSILE
MNENESIKGYTLDPSLGNVAFSSGKQCWGFTLKTFARIYSQKFSTKEETLMTKLWGDNYF
NPQTKQFTSELISNNTQNKQASRSFIEFVLVPLDKYYSASSNAEIETLSKMVEKLNLSSI
LTSAELERLKQVDVQERIKRSMRAWLPLADAILEMVQDHLPSPKEAMKYRSLYLYEGPAG
DEACAAMRECNSEGPLMVYISKMVQTEDLGRFYAFGRVFSGTISQGMKVRVQGPDYKPGS
KEDLFIKTIQHTFLMMGKQHEPIESVPAGGTVLILGVDNALTKTGTLTTSETAHNIRNMK
YTISPILRVAVNTPNQQDLTRLLEGLKMLQKYDPLVQVEVEENTGSYVVAGSGELHIKIC
LEKLNDFTHNSINIVASQPTVSYRETIAEKSSQTCLAKTENKLNHLYGTCEPLDEELGSA
IVSKKINIKDINNQKMINSLVNDYSWEREDAKRIWCFGPLEKESTNCIVNQTVGIQGMPA
IQPSIITAFEWCTKEGLLCDEPLRNIRFNIMDVIIHDEPAHHRSNQITPAARRLFKACQY
VSEPKILEPFYLCNIKTPDERKGPIYAFLNKFLDKRRGLVLGEEYDDIFTVIQAYIPVSE
SFGFDQAIKSVSQGMAMPALSFSHWQAVQGNPLDPESESGKIVNEIRIRKGLNAKIPELN
YYLDKL