Identifiers and Description

Gene Model Identifier

TTHERM_00989490

Standard Name

VPS42 (Vacuolar Protein Sorting 4-2)

Aliases

PreTt07839 | 185.m00060 | VPS4B

Description

AAA-type ATPase; ATPase- AAA family protein; associated with membrane vesicle trafficking; putative function in programmed nuclear death

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• cytoplasmic vesicle (IDA) | GO:0031410
• macronucleus (IDA) | GO:0031039
• vacuole (IDA) | GO:0005773

Molecular Function

• ATP binding (IEA) | GO:0005524
• ATP hydrolysis activity (IEA) | GO:0016887

Domains

• ( PF00004 ) ATPase family associated with various cellular activities (AAA)
• ( PF02189 ) Immunoreceptor tyrosine-based activation motif
• ( PF04212 ) MIT (microtubule interacting and transport) domain
• ( PF07724 ) AAA domain (Cdc48 subfamily)
• ( PF07726 ) ATPase family associated with various cellular activities (AAA)
• ( PF07728 ) AAA domain (dynein-related subfamily)
• ( PF09336 ) Vps4 C terminal oligomerisation domain
• ( TIGR01241 ) ATP-dependent metallopeptidase HflB
• ( TIGR01242 ) 26S proteasome subunit P45 family
• ( TIGR02237 ) DNA repair and recombination protein
• ( TIGR02880 ) CbbX protein

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_02920.1	9.997093137033517e-262
	Description: ATPase, AAA family protein (493 aa)
WormBase	WBGene00003186	9.997093137033517e-262
	Description: locus:mek-2 Dual specificity mitogen-activated protein kinase kinase mek-2 status:Confirmed UniProt:Q10664 protein_id:CCD73487.1
Oxytricha	Contig13722.0.g102	3.998176907651524e-145
	Description: ATPase family associated with various cellular activities (AAA)
SGD	YPR173C	1.000157752625888e-137
	Description: VPS4 AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism
DictyBase	DDB_G0284347	1.0001366335892501e-125
	Description: vps4 on chromosome: 4 position 1865073 to 1866634
WormBase	WBGene00021334	3.9996672065071595e-120
	Description: locus:vps-4 status:Confirmed UniProt:Q9BL83 protein_id:CCD68056.1
Stentor Coeruleus	SteCoe_15482	1.580420060273613e-61
	Description: None

General Information

No Data fetched for General Information

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00989490(coding)
ATGAGCAATAACCCTATGATGTAATTTAGAGACATCGCTCTCTAAAAAATTACTCAAGGT
ATTAACATCTTTAATACCAAGAAGGATAACATTAATGAAAGAGATTAAGGTTATAGGTTG
ATGGTTTCTGGTCTTGAAGACTTAATCAAGTATAGAAAGCAAGAAACAAATGTTGATATT
TAAAATATTTTAAAGCCAAAGATAGATGAATATTTAAAGCAAGCAGCTGCCATGAAAGCT
GAAATTTCTGCCTAATAACAGAACATTAATCAATAGATTCAAAAGCAATCTTAATTTAGC
TATCAAGCAAACAATTAAAATTTGAATAATATTAACACTAATATGAATAATAATAATAAT
CAAAATTAATATAAGCCTCCAGTTAACAACAACAACAACAACAATAATAGCAATAACACC
AATAACAATAATGGTGGAAATAACTAAAACAATAACTAAGGAAAAAGTTAAATCAAGGAA
GGTGATAAAGATAATGCTAAGTTTGAACAAGCATTAGGTGAAGCAATTGTTACTGAAAAG
CCAAATGTTCACTGGTCTGATGTTGCTGGTTTAGAAAATGCTAAGAAAGCACTTAATGAA
GCAGTTATCCTACCCATCAGATTCCCTCATATATTCTAAGGTATGATCAAGCCTTGGAGA
GGTATTTTGTTATATGGACCTCCAGGTACTGGTAAAACATTCTTGGCTAAGGCTTGTGCA
ACAGAATGTGATGCTACCTTCTTCTCTATTTCCTCCTCTGATTTAATTTCTAAGTGGGTT
GGTGAATCTGAAAAGTTAATTAAGACTTTGTTTAAAATGGCCAGAGAGAAAAAACCTTCT
ATTATATTTATTGACGAAATAGATTCAATGACTGGAAATAGATCTGAAGGTGAGAATGAA
GCATCCAGAAGAGTCAAAACTGAATTTTTAGTTTAAATGCAAGGTGTTGGCAATGATGAC
ACTGGTGTTCTTGTCCTTGGTGCTACAAACGTTCCTTGGGGTTTAGATCCTGCTATTAGA
AGAAGATTTGAAAAAAGAATTATGATTCCTTTACCAGAAAAGGAAGCTAGATTCTAATTG
ATTGACAATCTCTTGAATAAAACTCCCAACTGCATTACATAAGAAGAAAGATTATACATT
GCAGAAAGAACTGAAGGTTTTTCAGGTTCTGATATATCTATTTTAGTTAGAGAAGCTTCA
TATGAGCCTCTGAGAATAGCATAAAGAGCCACTAAATTCAAAAAGATTTAAGACAAAGAT
GGCTAACCTAAGTATGTTGCTTGTGCTCCTAGTGATCCCTAAGGTGAATCAAAAGTATTA
ATGGATATATAAGGTAGTATGTTAAAATTGTAAGATGTCAGTATAGATCACTTCGAATTA
GCCTTGTAATCTTGTAAACCCTCAGTCTCTGAAAAAGATATAGAGAGACAAATTGAATTC
ACTAAAGAATTCGGCCAAGATGGTTGA

>TTHERM_00989490(gene)
ATGAGCAATAACCCTATGATGTAATTTAGAGACATCGCTCTCTAAAAAATTACTCAAGGT
ATTAACATCTTTAATACCAAGAAGGATAACATTAATGAAAGAGATTAAGGTTATAGGTTG
ATGGTTTCTGGTCTTGAAGACTTAATCAAGTATAGAAAGCAAGAAACAAATGTTGATATT
TAAAATATTTTAAAGCCAAAGATAGATGAATATTTAAAGCAAGCAGCTGCCATGAAAGCT
GAAATTTCTGCCTAATAACAGAACATTAATCAATAGATTCAAAAGCAATCTTAATTTAGC
TATCAAGCAAACAATTAAAATTTGAATAATATTAACACTAATATGAATAATAATAATAAT
CAAAATTAATATAAGCCTCCAGTTAACAACAACAACAACAACAATAATAGCAATAACACC
AATAACAATAATGGTGGAAATAACTAAAACAATAACTAAGGAAAAAGTTAAATCAAGTAA
AAAGTTAATTTTGTTAGGATGATTTTTTTTAATTGTTTTTTATATCGATAGGGAAGGTGA
TAAAGATAATGCTAAGTTTGAACAAGCATTAGGTGAAGCAATTGTTACTGAAAAGCCAAA
TGTTCACTGGTCTGATGTTGCTGGTTTAGAAAATGCTAAGAAAGCACTTAATGAAGCAGT
TATCCTACCCATCAGATTCCCTCATATATTCTAAGGTATGATCAAGCCTTGGAGAGGTAT
TTTGTTATATGGACCTCCAGGTACTGGTAAAACATTCTTGGCTAAGGCTTGTGCAACAGA
ATGTGATGCTACCTTCTTCTCTATTTCCTCCTCTGATTTAATTTCTAAGTGGGTTGGTGA
ATCTGAAAAGTTAATTAAGACTTTGTTTAAAATGGCCAGAGAGAAAAAACCTTCTATTAT
ATTTATTGACGAAATAGATTCAATGACTGGAAATAGGTAAAAATATTACTTATGAAAATT
GTGACAATTTCTTGATTCATTCATAGATTATTTTTTTTTTAAATGTTCATTTTTTTTATT
GACAGTTCAAATCAAATATTTGAAATATGTTGATGATTGCTTGAAAAAATATATCATTTT
TTAACTAAAAAATTGAATTTGCTTATGATTTATTGTAATAAAAAGATCTGAAGGTGAGAA
TGAAGCATCCAGAAGAGTCAAAACTGAATTTTTAGTTTAAATGCAAGGTGTTGGCAATGA
TGACACTGGTGTTCTTGTCCTTGGTGCTACAAACGTTCCTTGGGGTTTAGATCCTGCTAT
TAGAAGAAGGTAAAAACAATTATTGAAGTTAGTGAATGTGTTTTTTATTTATAAATTTTC
AAAAAATAATTAGATTTGAAAAAAGAATTATGATTCCTTTACCAGAAAAGGAAGCTAGAT
TCTAATTGATTGACAATCTCTTGAATAAAACTCCCAACTGCATTACATAAGAAGAAAGAT
TATACATTGCAGAAAGAACTGAAGGGTATTTATCCATTTTATATTATATTAATTTTTAAA
CTTGTTTATTAAAAATAGTTTTTCAGGTTCTGATATATCTATTTTAGTTAGAGAAGCTTC
ATATGAGCCTCTGAGAATAGCATAAAGAGCCACTAAATTCAAAAAGATTTAAGACAAAGA
TGGCTAACCTAAGTATGTTGCTTGTGCTCCTAGTGATCCCTAAGGTGAATCAAAAGTATT
AATGGATATATAAGGTAGTATGTTAAAATTGTAAGATGTCAGTATAGATCACTTCGAATT
AGCCTTGTAATCTTGTAAACCCTCAGTCTCTGAAAAAGATATAGAGAGACAAATTGAATT
CACTAAAGAATTCGGCCAAGATGGTTGA

>TTHERM_00989490(protein)
MSNNPMMQFRDIALQKITQGINIFNTKKDNINERDQGYRLMVSGLEDLIKYRKQETNVDI
QNILKPKIDEYLKQAAAMKAEISAQQQNINQQIQKQSQFSYQANNQNLNNINTNMNNNNN
QNQYKPPVNNNNNNNNSNNTNNNNGGNNQNNNQGKSQIKEGDKDNAKFEQALGEAIVTEK
PNVHWSDVAGLENAKKALNEAVILPIRFPHIFQGMIKPWRGILLYGPPGTGKTFLAKACA
TECDATFFSISSSDLISKWVGESEKLIKTLFKMAREKKPSIIFIDEIDSMTGNRSEGENE
ASRRVKTEFLVQMQGVGNDDTGVLVLGATNVPWGLDPAIRRRFEKRIMIPLPEKEARFQL
IDNLLNKTPNCITQEERLYIAERTEGFSGSDISILVREASYEPLRIAQRATKFKKIQDKD
GQPKYVACAPSDPQGESKVLMDIQGSMLKLQDVSIDHFELALQSCKPSVSEKDIERQIEF
TKEFGQDG