Identifiers and Description

Gene Model Identifier

TTHERM_00997780

Standard Name

UBA1 (Ubiquitin-Activating enzyme; UBA1 ortholog)

Aliases

PreTt25003 | 188.m00079

Description

UBA1 ubiquitin-activating enzyme E1; ubiquitin-activating enzyme E1 family protein

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• ATP binding (IEA) | GO:0005524
• catalytic activity (IEA) | GO:0003824
• ubiquitin-like modifier activating enzyme activity (IEA) | GO:0008641

Biological Process

• cellular protein modification process (IEA) | GO:0006464

Domains

• ( PF00899 ) ThiF family
• ( PF02134 ) Repeat in ubiquitin-activating (UBA) protein
• ( TIGR00984 ) mitochondrial import inner membrane, translocase
• ( TIGR01408 ) ubiquitin-activating enzyme E1
• ( TIGR01766 ) transposase, IS605 OrfB family
• ( TIGR02354 ) thiamine biosynthesis protein ThiF
• ( TIGR02355 ) molybdopterin synthase sulfurylase MoeB
• ( TIGR02356 ) thiazole biosynthesis adenylyltransferase ThiF

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Stentor Coeruleus	SteCoe_18172	0
	Description: None
WormBase	WBGene00006699	9.997093137033517e-262
	Description: locus:uba-1 status:Confirmed UniProt:Q3S1J5 protein_id:CAJ30225.1
Tetrahymena borealis	EI9_20921.1	9.997093137033517e-262
	Description: ubiquitin-activating enzyme E1 family protein (1038 aa)
DictyBase	DDB_G0270272	9.997093137033517e-262
	Description: uae1 on chromosome: 1 position 4544769 to 4548249
Oxytricha	Contig20907.0.g36	9.997093137033517e-262
	Description: ThiF family
SGD	YKL210W	9.997093137033517e-262
	Description: UBA1 Ubiquitin activating enzyme (E1), involved in ubiquitin-mediated protein degradation and essential for viability

General Information

No Data fetched for General Information

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00997780(coding)
ATGGCTGAGACTGGAAAGATTGATGAAAACTTGTACTCAAGAATGATGGGTGCATACGGA
GTTGAAGCTGTAGGAAAGTTAGTTAAGCTAAAGATTTTCCTATCAGGCCTTAGAGGTGTT
GGTATCGAAACAGCAAAGAATTTAATTTTAAGTGGTCCCTCTGCAGTTTGCTTGCACGAT
GATAGCCTTGCTGAAGTTGCTAATATGGGCTGCAATTTCTATCTAAAGCCTGAGCATATT
GGTAAAGTTACTCGTGCTGAAGCTTCTCTTCCTTAATTAAAGGAATTAAATCCCTATTGC
AAGGTTTCAGTTCACACTGGTTAAATTACAAAGGAATTATTAGCAGATTTTGATGTTGTT
GTTATCACTGACAATTACAACCAAGATGAAATTGTTGATATCAATGCTTACTGCAGAGCT
AATAAAAAGGGTTTCATATATTCAGGCATCTTAGGTCTTTACGGCTTGTGCTTTGTTGAT
TTTGGTGATAGCCATTCAGTTTTTGATACAAATGGTGAAGAACCTCGTAACTCTATTGTT
GTTGGTGTTACCCAAGATGCTGAAGGTTTAGTTACAGTTCATGAAGACAAGAGACACGGT
TTCTAGTCTGGTGATTACGTTACATTCAGAGAAATCTAAGGTATGAGCGAATTGAACGAC
AAGGTTTTCAAAATTGAAGAAAAGAGTCCCTTCACTTTTACTCTTGTTGGTGTTGATACC
ACCAAGTTCTAGCCTTACTTACGTGAAGGTATTGTTGAATAAGTTAAGGTTCCCGTCTAG
ATTGCTTTCAAGAGCTTGGGCGAAAGTCTTAGCAAGCCTTATGCTCCTGGCAAGAATGAA
TTAGATATTTGTGATTGGGAAAAGTTTGGTAGACCTGAATAGCTCCATTTAGCTTTCACT
GGTTTATTGACTTTTGTTAAGCAAAATGGCCACCTCCCTGCTCTTCATTCTTAGGAAGAT
GCTGAAAAGCTTCTCCATATTGTTAAGGATATTAATACTCAAAGAAAAAACATTGACGAA
GAAGGTGTCCTCAAGGTAGAAGAAATTGAAGAGTAAATTGTTAAAAATATTGCTCTCTAT
GCTCGTGCATAAATTACTCCTCTTTCTTCTTTCTGGGGTGGTATTGTAGCTCAAGAAATT
GTCAAGTACACAGGTAAATTCACTCCTCTTAGATAATGGTTGCATTATGAATGCTTCGAA
GCTCTTCCCGAAGGTGAAGTAGATAGAACTTTATTGAACTCTCAATATGATGACTAGATT
GCTATCTTTGGTAGAGAATTCTAACAAAAGTTACTCGAACAACGTACTTTCTTAGTTGGT
GCTGGTGCTTTAGGATGTGAATATATTAAAATGTTCGCCTTGATGGGTTTGGGAAGTGAA
AAGAATGGAGGTGTTGTCGTTACTGATGATGACTAAATTGAAATGTCCAATCTCAATAGA
TAGTTCCTCTTCCGTAAGGAAAATATTGGTCACTCCAAGTCAGAATGTGCAACTCGTGCT
GGTAAAATAATGAATCCTAAGCTTCACATCGAAGCTCTTAAAGAAAGAGTTGATCCTGAA
AATGAAAGAATCTTTAACGATGCTTTCTGGGAGGGTCTCGATTTCGTAGTTAATGCTGTC
GATAATGTAAAGGCTCGTCTATTTGTCGATGGACGTTGCGTTTGGTATGGTAAACCCCTT
TTCGAATCAGGTACTCTAGGAACTAAATGTAACTCTTAAATAGTTCTTCCTAAGCTCACT
TAATCTTATGGTGATTCTGTTGATCCTCCTGAGGAATCCATTCCTTTGTGCACATTGAAG
AACTTCCCTTACCAAATTGAACACACTATTTAATGGGCTCGTGACTATTTTGAAGGTAAC
TTGGTAGAAGGTCCTAATGAAACTTCAAAGTATGTAGAAAATCCTCAAGCCTACATTGAA
TAAGTAACTAAAGAACTTCGTAGCAAGCCCGTTATGTTGAGAGGCCGTTTGGAAATTGTT
AAGAAATTGGCAACTGCTTACTCTGGTAACCACTACGACAAGTGCATTGAACTCGCAAGA
CACATGTTCTAAGATATTTTCTATAATTAGATTTCTTAACTTCTCTACTCTTTCCCTCTT
GACCACAAGACTGAATCAGGCTAACCTTTCTGGTCAGGACCCAAGAGACCTCCTATTCCT
ATTAAATTCGATACCAATGACGATATTCATGTCGACTTTATTTAATCTGCTGCTAATGTA
TTTGCATTCATTTTCGGTCTCCCTTACTGCCATGATAGGGAATACGTCAAGAAGGCTGCA
AACTCAGTACATGTTGAAGAATTTGTTCCTAAAAAAGCTAGCATTAAGGTAGACGATAAA
GATAAAACTGAAGAAAAAGTCGAAGACGATGAAATTGTCATTGAAAACTTAACCAAGGAG
TTGTTGAATTTCAATCTCTCTTAAAATAAGCCAAAATTAAATCCTATCGAATTTGAAAAA
GACGACCCAACCAACTGGCACATTGATTTTATTTCATCTGTTGCTAACTTACGTGCCCGT
AACTATAAGATCAAGGAAGTTACCAAGTTTAAGGTTAAAATGATTGCTGGTAAAATTATT
CCTGCTCTTGCTACAACCACTGCCATGGTCGTAGGTGCTGTCGGTATTGAAATCTTCAAA
TATATACTCTAAAAGCCTCTTAACAAGATGAAAAACTCCTTTATGAATCTTGCTCTTCCC
TTATGGATCTTCTCTGAACCTGAACCTCCCATTAAGGCAAAGGATAAAGATTATGATCCC
GTATTGATGGGACCTGTTAAGGCTATTCCCTCTGGTTTCACTACATGGGATAAGCTCTTC
GTCTAAGGTCCTCTTACTATTTAAGGTCTTAAGGATTATTTCAATGATAAATATCAAGTA
AATATCTCCATTTTATCAGTTGGTAAAATCTGTCTCTACAATTCATACATGACAGAGGCT
GCTGAAAGAGAAAGTTGGGATATAGCTCAAGGAGTTGAAAAGCTTGGAGGTTAACCTATT
CCAGACTTTAAAAAGTTCTTAGAATTAGAAATCTGTGCTGAAACTCAAACTGGTGAAGAT
GCCCTTATGCCCACAATTAAGTATGCATTCAAAGCTTGA

>TTHERM_00997780(gene)
ATGGCTGAGACTGGAAAGATTGATGAAAACTTGTACTCAAGAATGATGGGTGCATACGGA
GTTGAAGCTGTAGGAAAGTTAGTTAAGCTAAAGATTTTCCTATCAGGCCTTAGAGGTGTA
AGATATTAATTTTCATCATTTTATTATTCTTCTTGTCAAAAAAAATAAATAAATAAACAA
ACAAATAAACAAAAAAACATACGTTATGGCAATTTTAAATACTTTTTGATTGAGATTATC
TCTACTAATACAAAAAATACAGTTTTAGAATAACTGTTAACCATTAAACATGCTTAAACT
AAAGATAACGCTAGTTTTTTTAATGTTTTAAAGACAAAATCAAAAAATTATGCTAAACAG
TTTTTATTTTAAAAACGAACGATATCTTATTTAAAAATAGGTTGGTATCGAAACAGCAAA
GAATTTAATTTTAAGTGGTCCCTCTGCAGTTTGCTTGCACGATGATAGCCTTGCTGAAGT
TGCTAATATGGGCTGCAATTTCTATCTAAAGCCTGAGCATATTGGTAAAGTTACTCGTGC
TGAAGCTTCTCTTCCTTAATTAAAGGAATTAAATCCCTATTGCAAGGTTTCAGTTCACAC
TGGTTAAATTACAAAGGAATTATTAGCAGATTTTGATGTTGTTGTTATCACTGACAATTA
CAACCAAGATGAAATTGTTGATATCAATGCTTACTGCAGAGCTAATAAAAAGGGTTTCAT
ATATTCAGGCATCTTAGGTCTTTACGGCTTGTGCTTTGTTGATTTTGGTGATAGCCATTC
AGTTTTTGATACAAATGGTGAAGAACCTCGTAACTCTATTGTTGTTGGTGTTACCCAAGA
TGCTGAAGGTTTAGTTACAGTTCATGAAGACAAGAGACACGGTTTCTAGTCTGGTGATTA
CGTTACATTCAGAGAAATCTAAGGTATGAGCGAATTGAACGACAAGGTTTTCAAAATTGA
AGAAAAGAGTCCCTTCACTTTTACTCTTGTTGGTGTTGATACCACCAAGTTCTAGCCTTA
CTTACGTGAAGGTATTGTTGAATAAGTTAAGGTTCCCGTCTAGATTGCTTTCAAGAGCTT
GGGCGAAAGTCTTAGCAAGCCTTATGCTCCTGGCAAGAATGAATTAGATATTTGTGATTG
GGAAAAGTTTGGTAGACCTGAATAGCTCCATTTAGCTTTCACTGGTTTATTGACTTTTGT
TAAGCAAAATGGCCACCTCCCTGCTCTTCATTCTTAGGAAGATGCTGAAAAGCTTCTCCA
TATTGTTAAGGATATTAATACTCAAAGAAAAAACATTGACGAAGAAGGTGTCCTCAAGGT
AGAAGAAATTGAAGAGTAAATTGTTAAAAATATTGCTCTCTATGCTCGTGCATAAATTAC
TCCTCTTTCTTCTTTCTGGGGTGGTATTGTAGCTCAAGAAATTGTCAAGTACACAGGTAA
ATTCACTCCTCTTAGATAATGGTTGCATTATGAATGCTTCGAAGCTCTTCCCGAAGGTGA
AGTAGATAGAACTTTATTGAACTCTCAATATGATGACTAGATTGCTATCTTTGGTAGAGA
ATTCTAACAAAAGTTACTCGAACAACGTACTTTCTTAGTTGGTGCTGGTGCTTTAGGATG
TGAATATATTAAAATGTTCGCCTTGATGGGTTTGGGAAGTGAAAAGAATGGAGGTGTTGT
CGTTACTGATGATGACTAAATTGAAATGTCCAATCTCAATAGATAGTTCCTCTTCCGTAA
GGAAAATATTGGTCACTCCAAGTCAGAATGTGCAACTCGTGCTGGTAAAATAATGAATCC
TAAGCTTCACATCGAAGCTCTTAAAGAAAGAGTTGATCCTGAAAATGAAAGAATCTTTAA
CGATGCTTTCTGGGAGGGTCTCGATTTCGTAGTTAATGCTGTCGATAATGTAAAGGCTCG
TCTATTTGTCGATGGACGTTGCGTTTGGTATGGTAAACCCCTTTTCGAATCAGGTACTCT
AGGAACTAAATGTAACTCTTAAATAGTTCTTCCTAAGCTCACTTAATCTTATGGTGATTC
TGTTGATCCTCCTGAGGAATCCATTCCTTTGTGCACATTGAAGAACTTCCCTTACCAAAT
TGAACACACTATTTAATGGGCTCGTGACTATTTTGAAGGTAACTTGGTAGAAGGTCCTAA
TGAAACTTCAAAGTATGTAGAAAATCCTCAAGCCTACATTGAATAAGTAACTAAAGAACT
TCGTAGCAAGCCCGTTATGTTGAGAGGCCGTTTGGAAATTGTTAAGAAATTGGCAACTGC
TTACTCTGGTAACCACTACGACAAGTGCATTGAACTCGCAAGACACATGTTCTAAGATAT
TTTCTATAATTAGATTTCTTAACTTCTCTACTCTTTCCCTCTTGACCACAAGACTGAATC
AGGCTAACCTTTCTGGTCAGGACCCAAGAGACCTCCTATTCCTATTAAATTCGATACCAA
TGACGATATTCATGTCGACTTTATTTAATCTGCTGCTAATGTATTTGCATTCATTTTCGG
TCTCCCTTACTGCCATGATAGGGAATACGTCAAGAAGGCTGCAAACTCAGTACATGTTGA
AGAATTTGTTCCTAAAAAAGCTAGCATTAAGGTAGACGATAAAGATAAAACTGAAGAAAA
AGTCGAAGACGATGAAATTGTCATTGAAAACTTAACCAAGGAGTTGTTGAATTTCAATCT
CTCTTAAAATAAGCCAAAATTAAATCCTATCGAATTTGAAAAAGACGACCCAACCAACTG
GCACATTGATTTTATTTCATCTGTTGCTAACTTACGTGCCCGTAACTATAAGATCAAGGA
AGTTACCAAGTTTAAGGTTAAAATGATTGCTGGTAAAATTATTCCTGCTCTTGCTACAAC
CACTGCCATGGTCGTAGGTGCTGTCGGTATTGAAATCTTCAAATATATACTCTAAAAGCC
TCTTAACAAGATGAAAAACTCCTTTATGAATCTTGCTCTTCCCTTATGGATCTTCTCTGA
ACCTGAACCTCCCATTAAGGCAAAGGATAAAGATTATGATCCCGTATTGATGGGACCTGT
TAAGGCTATTCCCTCTGGTTTCACTACATGGGATAAGCTCTTCGTCTAAGGTCCTCTTAC
TATTTAAGGTCTTAAGGATTATTTCAATGATAAATATCAAGTAAATATCTCCATTTTATC
AGTTGGTAAAATCTGTCTCTACAATTCATACATGACAGAGGCTGCTGAAAGGTAAATTAC
ATTCATTTATTTATTTATTACATTTTATTTAAATTTTTAAAATTATAAACAGAGAAAGTT
GGGATATAGCTCAAGGAGTTGAAAAGCTTGGAGGTTAACCTATTCCAGACTTTAAAAAGT
TCTTAGAATTAGAAATCTGTGCTGAAACTCAAACTGGTGAAGATGCCCTTATGCCCACAA
TTAAGTATGCATTCAAAGCTTGA

>TTHERM_00997780(protein)
MAETGKIDENLYSRMMGAYGVEAVGKLVKLKIFLSGLRGVGIETAKNLILSGPSAVCLHD
DSLAEVANMGCNFYLKPEHIGKVTRAEASLPQLKELNPYCKVSVHTGQITKELLADFDVV
VITDNYNQDEIVDINAYCRANKKGFIYSGILGLYGLCFVDFGDSHSVFDTNGEEPRNSIV
VGVTQDAEGLVTVHEDKRHGFQSGDYVTFREIQGMSELNDKVFKIEEKSPFTFTLVGVDT
TKFQPYLREGIVEQVKVPVQIAFKSLGESLSKPYAPGKNELDICDWEKFGRPEQLHLAFT
GLLTFVKQNGHLPALHSQEDAEKLLHIVKDINTQRKNIDEEGVLKVEEIEEQIVKNIALY
ARAQITPLSSFWGGIVAQEIVKYTGKFTPLRQWLHYECFEALPEGEVDRTLLNSQYDDQI
AIFGREFQQKLLEQRTFLVGAGALGCEYIKMFALMGLGSEKNGGVVVTDDDQIEMSNLNR
QFLFRKENIGHSKSECATRAGKIMNPKLHIEALKERVDPENERIFNDAFWEGLDFVVNAV
DNVKARLFVDGRCVWYGKPLFESGTLGTKCNSQIVLPKLTQSYGDSVDPPEESIPLCTLK
NFPYQIEHTIQWARDYFEGNLVEGPNETSKYVENPQAYIEQVTKELRSKPVMLRGRLEIV
KKLATAYSGNHYDKCIELARHMFQDIFYNQISQLLYSFPLDHKTESGQPFWSGPKRPPIP
IKFDTNDDIHVDFIQSAANVFAFIFGLPYCHDREYVKKAANSVHVEEFVPKKASIKVDDK
DKTEEKVEDDEIVIENLTKELLNFNLSQNKPKLNPIEFEKDDPTNWHIDFISSVANLRAR
NYKIKEVTKFKVKMIAGKIIPALATTTAMVVGAVGIEIFKYILQKPLNKMKNSFMNLALP
LWIFSEPEPPIKAKDKDYDPVLMGPVKAIPSGFTTWDKLFVQGPLTIQGLKDYFNDKYQV
NISILSVGKICLYNSYMTEAAERESWDIAQGVEKLGGQPIPDFKKFLELEICAETQTGED
ALMPTIKYAFKA