Identifiers and Description

Gene Model Identifier

TTHERM_01008630

Standard Name

THC1 (Tetrahymanol cyclase)

Aliases

PreTt29567 | 194.m00023

Description

THC1 squalene-tetrahymanol cyclase; Metabolic enzyme involved in triterpenoids biosynthesis; catalyzes the formation of tetrahymanol from squalene by a direct cyclization. (US PATENT 7105324 B2- 2006)

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• catalytic activity (IEA) | GO:0003824
• zinc ion binding (IEA) | GO:0008270

Domains

• ( PF00432 ) Prenyltransferase and squalene oxidase repeat
• ( PF01473 ) Putative cell wall binding repeat
• ( PF01753 ) MYND finger
• ( PF07678 ) A-macroglobulin TED domain
• ( PF07966 ) A1 Propeptide
• ( TIGR00072 ) hydrogenase maturation protease
• ( TIGR00255 ) conserved hypothetical protein TIGR00255
• ( TIGR01507 ) squalene-hopene cyclase
• ( TIGR01787 ) squalene/oxidosqualene cyclases

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_13560.1	9.997093137033517e-262
	Description: hypothetical protein (656 aa)
WormBase	WBGene00000962	9.997093137033517e-262
	Description: locus:dhc-1 Dynein heavy chain, cytoplasmic status:Partially_confirmed UniProt:Q19020 protein_id:CCD64267.1
DictyBase	DDB_G0269226	5.997612587164444e-16
	Description: cas1 on chromosome: 1 position 3476704 to 3479389
SGD	YHR072W	0.00000000002000577768187062
	Description: ERG7 Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis

General Information

No Data fetched for General Information

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_01008630(coding)
ATGAAGAAGATACTCATAGGCTTAATTATAGGTCTCTTTTTATTCTCAAGCGTTAATGCC
AGCGTTAATCTCACTGAAGTCTAAAATGCCATCTCTATCTAGCAAGGCATTAATTGGGCA
GAAGTACACAACAATACTTGGTACTATCCTCCTTACTTAGGCGAAATGTTTATCAGTGAA
TACTACTTCGAGTTACTCGTCTTGAATTGGACTCATAAATCTGCTTTCAACGCTACATAC
TTTACAGAACGTCTCCTCTAGACTTAATTCGAAGATGGTTCATGGGAGCAAGTCAGAGAA
CAAAATCTTGAAACTGGTTAGTTAGATGCTACTGTCTTTAACTACTGGTACTTAAAGTCT
ATTAACAACAATCCTAAAATTGAAGCTGCTCTATAAAAGGCTAGAAAATGGATAGTTGCT
TAGGGTGGTATTGAAGCAACTCAAACAATGACCAAGTTTAAGTTAGCAGCCTTCGGTTAA
TACAGTTGGGAAGATTTATGGTATGTCCCATTGTTCATCTTCAAGTAGAATGGAATTTTC
AAATATACCTACGTTAAGGATATTGTTGCATAATGGGTCTATCCACATTTAACTGCCTTA
GCTTATTTGCGTTACTAAAGAACTGTTTTCAATGTTCCTGTTGCTGATTTGAGAGAGCTC
TGGATCAATTACCCTAAGAACGGTATTAAAATCAGTCCAAGAGAATACTCTACACTTAAT
CCTGATAGCGATCTCTTGATCTTAATGGACGAAATCTTCAAACTTAAACAACCTCTTGGA
AGTTTCGGTGCCTACACTATTTCAACCCTCTTGACTTTAATGTCCTTCAAAGACTTTTAG
TCAAAGCACCCTCATCTATACCAAAACGAAATACAAAAGGCTTACGAAGACGGATACTAT
TTCGTTGAGTTTAACTACTTTAACTTTAGAGAAGCTTATCACGGCTCTTTGGATGATGGT
AGATGGTGGGATACCATTCTTATTAGTTGGGCTATGCTTGAAAGTGGCTAAGATAAAGAA
AGAATCTTCCCTATCGTATAAAATATGGTCAAAGAAGGTCTTTAACCTAAAAAAGGTATA
GGTTATGGATATGATTTCGAATATGCTCCTGACACTGATGACACTGGATTACTTCTCGTT
GTTATGAGTTACTACAAAGAAGCCTTCTAAAAGTAAATCCCTGAAACTATTGAATGGCTT
TTCTCTATGCAAAATGACGATGGTGGCTATCCAGCTTTTGACAAAGGTAAAAATGAAGAC
AATTTATTGTTCAAGTTTGCCTTCAATATGGCTGGTATTGCTAACTCAGCTGAAATCTTC
GATCCCTCATGTCCTGATATTACTGGTCACATCATGGAAGGATTGGGTGAGTTTGGATAT
CAAGCTAATCATCCTTAGATTTAAAATATGATTAAATATCAAAGAAAGACTTAGAACAAG
TGGGGATCTTGGTAAGCTAGATGGGGTGTAAATTACATTATGGCTGTTGGAGCTGTTGTA
CCAGGTTTAGCAAGAGTCAATTACGACTTAAATGAACAGTGGGTACAAAATAGTATAAAT
TATTTGCTTAATAAATAAAATAAAGATGGTGGCTTTGGTGAATGTGTCCTTTCTTATAAT
GATCCTGAAAAGTGGAATGGTATAGGTAAATCTACTGTCACTCAAACCTCATGGGGACTA
TTAGCTCTTTTAGAAGTTTATAATTAAAATGAACAAATTAAGCATGCTGCAGATAGAGCT
GCTTAGTATTTATTAGATTAATTCAAAAGAGACGATAATACCTTCTATGATCACTCCACA
ATAGGAACAGGTCACAGAGGATTACTCTATTTATAGTACCCCTCATATGCACAATCATTC
CCATTAGTAGCTTTAAATAGATACTAAAAAATATCTCAAGGTTAATATCACTTCTCCAAA
AATTTGTACAATGGTAATGGAGAACCTGTATAAAAATAAAATATTTGA

>TTHERM_01008630(gene)
ATGAAGAAGATACTCATAGGCTTAATTATAGGTCTCTTTTTATTCTCAAGCGTTAATGCC
AGCGTTAATCTCACTGAAGTCTAAAATGCCATCTCTATCTAGCAAGGCATTAATTGGGCA
GAAGTACACAACAATACTTGGTACTATCCTCCTTACTTAGGCGAAATGTTTATCAGTGAA
TACTACTTCGAGTTACTCGTCTTGAATTGGACTCATAAATCTGCTTTCAACGCTACATAC
TTTACAGAACGTCTCCTCTAGACTTAATTCGAAGATGGTTCATGGGAGCAAGTCAGAGAA
CAAAATCTTGAAACTGGTTAGTTAGATGCTACTGTCTTTAACTACTGGTACTTAAAGTCT
ATTAACAACAATCCTAAAATTGAAGCTGCTCTATAAAAGGCTAGAAAATGGATAGTTGCT
TAGGGTGGTATTGAAGCAACTCAAACAATGACCAAGTTTAAGTTAGCAGCCTTCGGTTAA
TACAGGTAAAGTTTCTTTTTCATCAATATTTTAGAAATAAACAATCAATTTTAAATTATT
CTCCCATATTTTGCTCAAATAATAATTTCTACTTAAATAATTAGCTTCAACTGCAAATAT
AAAAATGAATTAATTTATTATAAATAAAAGCAGTAAATATAAGCAAATATACTAATTTAA
TTAGCTTATTATTCTGTTAATATTTAAAAGCCATTTTGACTCAATAGCTTATTTTATTTT
AAATAATTAAATAGTTGGGAAGATTTATGGTATGTCCCATTGTTCATCTTCAAGTAGAAT
GGAATTTTCAAATATACCTACGTTAAGGATATTGTTGCATAATGGGTCTATCCACATTTA
ACTGCCTTAGCTTATTTGCGTTACTAAAGAACTGTTTTCAATGTTCCTGTTGCTGATTTG
AGAGAGCTCTGGATCAATTACCCTAAGAACGGTATTAAAATCAGTCCAAGAGAATACTCT
ACACTTAATCCTGATAGCGATCTCTTGATCTTAATGGACGAAATCTTCAAACTTAAACAA
CCTCTTGGAAGTTTCGGTGCCTACACTATTTCAACCCTCTTGACTTTAATGTCCTTCAAA
GACTTTTAGTCAAAGCACCCTCATCTATACCAAAACGAAATACAAAAGGCTTACGAAGAC
GGATACTATTTCGTTGAGTTTAACTACTTTAACTTTAGAGAAGCTTATCACGGCTCTTTG
GATGATGGTAGATGGTGGGATACCATTCTTATTAGTTGGGCTATGCTTGAAAGTGGCTAA
GATAAAGAAAGAATCTTCCCTATCGTATAAAATATGGTCAAAGAAGGTCTTTAACCTAAA
AAAGGTATAGGTTATGGATATGATTTCGAATATGCTCCTGACACTGATGACACTGGATTA
CTTCTCGTTGTTATGAGTTACTACAAAGAAGCCTTCTAAAAGTAAATCCCTGAAACTATT
GAATGGCTTTTCTCTATGCAAAATGACGATGGTGGCTATCCAGCTTTTGACAAAGGTAAT
TTAATATTGATAATTTATTCCATTTCTTTATTTAATAAAAATAAATCTTTTAATTATTTC
AATTGAAAGATACATTTAAATAAAATTACAAATGTACTTAAAATAAATATAATATTATTA
ACACTTCTACTTTATTTTAAAATAGGTAAAAATGAAGACAATTTATTGTTCAAGTTTGCC
TTCAATATGGCTGGTATTGCTAACTCAGCTGAAATCTTCGATCCCTCATGTCCTGATATT
ACTGGTCACATCATGGAAGGATTGGGTGAGTTTGGATATCAAGCTAATCATCCTTAGATT
TAAAATATGATTAAATATCAAAGAAAGACTTAGAACAAGTGGGGATCTTGGTAAGCTAGA
TGGGGTGTAAATTACATTATGGCTGTTGGAGCTGTTGTACCAGGTTTAGCAAGAGTCAAT
TACGACTTAAATGAACAGTGGGTACAAAATAGTATAAATTATTTGCTTAATAAATAAAAT
AAAGATGGTGGCTTTGGTGAATGTGTCCTTTCTTATAATGATCCTGAAAAGTGGAATGGT
ATAGGTAAATCTACTGTCACTCAAACCTCATGGGGACTATTAGCTCTTTTAGAAGTTTAT
AATTAAAATGAACAAATTAAGCATGCTGCAGATAGAGCTGCTTAGTATTTATTAGATTAA
TTCAAAAGAGACGATAATACCTTCTATGATCACTCCACAATAGGAACAGGTCACAGAGGA
TTACTCTATTTATAGTACCCCTCATATGCACAATCATTCCCATTAGTAGCTTTAAATAGA
TACTAAAAAATATCTCAAGGTTAATATCACTTCTCCAAAAATTTGTACAATGGTAATGGA
GAACCTGTATAAAAATAAAATATTTGA

>TTHERM_01008630(protein)
MKKILIGLIIGLFLFSSVNASVNLTEVQNAISIQQGINWAEVHNNTWYYPPYLGEMFISE
YYFELLVLNWTHKSAFNATYFTERLLQTQFEDGSWEQVREQNLETGQLDATVFNYWYLKS
INNNPKIEAALQKARKWIVAQGGIEATQTMTKFKLAAFGQYSWEDLWYVPLFIFKQNGIF
KYTYVKDIVAQWVYPHLTALAYLRYQRTVFNVPVADLRELWINYPKNGIKISPREYSTLN
PDSDLLILMDEIFKLKQPLGSFGAYTISTLLTLMSFKDFQSKHPHLYQNEIQKAYEDGYY
FVEFNYFNFREAYHGSLDDGRWWDTILISWAMLESGQDKERIFPIVQNMVKEGLQPKKGI
GYGYDFEYAPDTDDTGLLLVVMSYYKEAFQKQIPETIEWLFSMQNDDGGYPAFDKGKNED
NLLFKFAFNMAGIANSAEIFDPSCPDITGHIMEGLGEFGYQANHPQIQNMIKYQRKTQNK
WGSWQARWGVNYIMAVGAVVPGLARVNYDLNEQWVQNSINYLLNKQNKDGGFGECVLSYN
DPEKWNGIGKSTVTQTSWGLLALLEVYNQNEQIKHAADRAAQYLLDQFKRDDNTFYDHST
IGTGHRGLLYLQYPSYAQSFPLVALNRYQKISQGQYHFSKNLYNGNGEPVQKQNI