Identifiers and Description

Gene Model Identifier

TTHERM_01014700

Standard Name

THD4 (Tetrahymena histone deacetylase 4)

Aliases

PreTt04600 | 197.m00074 | 3748.m00310

Description

THD4 histone deacetylasehistone-like deacetylase family classII protein; Histone deacetylase family protein; Histone deacetylase and polyamine deacetylase

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• obsolete integral component of mitochondrial membrane (IEA) | GO:0032592

Molecular Function

• 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity (IEA) | GO:0008413
• axon guidance receptor activity (IEA) | GO:0008046
• carnitine:acyl carnitine antiporter activity (IEA) | GO:0005476
• histone acetyltransferase binding (IEA) | GO:0035035
• obsolete sodium-transporting two-sector ATPase activity (IEA) | GO:0015443
• phosphatidylserine decarboxylase activity (IEA) | GO:0004609
• sphingomyelin phosphodiesterase activity (IEA) | GO:0004767
• type 4 neuropeptide Y receptor binding (IEA) | GO:0031844

Biological Process

• cell wall modification involved in fruit ripening (IEA) | GO:0009829
• inactivation of recombination (HML) (IEA) | GO:0007537
• induction of apoptosis by extracellular signals (IEA) | GO:0008624
• interleukin-12 production (IEA) | GO:0032615
• interleukin-13 production (IEA) | GO:0032616
• lamellipodium morphogenesis (IEA) | GO:0072673
• negative regulation of complement-dependent cytotoxicity (IEA) | GO:1903660
• negative regulation of epithelial cell-cell adhesion involved in epithelium migration (IEA) | GO:1903682
• negative regulation of thiamine biosynthetic process (IEA) | GO:0070624
• ocellus pigment granule organization (IEA) | GO:0008058
• plant-type cell wall modification (IEA) | GO:0009827
• positive regulation of intracellular lipid transport (IEA) | GO:0032379
• positive regulation of peroxisome proliferator activated receptor signaling pathway (IEA) | GO:0035360
• positive regulation of response to water deprivation (IEA) | GO:1902584
• positive regulation of sterol transport (IEA) | GO:0032373
• positive regulation of wound healing, spreading of epidermal cells (IEA) | GO:1903691
• priming of cellular response to stress (IEA) | GO:0080136
• regulation of cholesterol transport (IEA) | GO:0032374
• regulation of complement-dependent cytotoxicity (IEA) | GO:1903659
• regulation of L-arginine import into cell (IEA) | GO:1902826

Domains

• ( PF00850 ) Histone deacetylase domain

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

No Data fetched for Homologs

General Information

No Data fetched for General Information

Associated Literature

1. Ref:18178773: Smith JJ, Torigoe SE, Maxson J, Fish LC, Wiley EA (2008) A class II histone deacetylase acts on newly synthesized histones in Tetrahymena. Eukaryotic cell 7(3):471-82

Sequences

>TTHERM_01014700(coding)
ATGATGGATGCCAAGGATAAAAAAGTAGGATTTATATATGATGAAAGAATGCTTTTACAT
AAACTCTCTAAGTAGCCTCCTCATCCTGAGTGCCCTGAAAGAATAGAAAAAATAATAGAA
AACTTAAAAAAAACTGGATTATGGAGTTAATTAGATGTAATTAACTAGGTAGAGCCAATT
TAAAAAGATATTTTAAATAAAGTGCACAGAGATTCATATGTAGATTTAGTAGAATAAATG
TGGCCTGAAGGCTGTGAAAAAGAAAACATGGTTTTAAATGGATGTTATTATAATAAGTAC
ACAGGATAAAGTGCTTTTTTGTCATCAGGTGCTGTAATTTAATCAATAGATTTGATCAAA
TCCAAATCTTGGCATACTGCTTTTTGTTGTGTTAGACCGCCTGGACATCACAGTGGAGCT
TCATAGTAGTGTAGTGGATTTTGTTTCTTTAACAATGTTGTTGTGGGAGCCAAGTATTTA
AGAGAAAAATATTCAGTCAAAAAAATAGCAATTTTCGATTTTGATGTACATCATGGAGAC
GGAACTCAAGCTCTTACATACGATGATCATGAATTGTTATTTATAAGTATACATTAGTAT
GATGAAGGAAAATTTTATCCTTTCTAAAGTGGAGATTTAAGTAAAGTAGGAAATGGATTT
AACATTAATATTGGTTGGAACACTTCAAATTTTTAAAGTGCTGGAGATGATGAATACATT
TATGCTTTTGAATCAATTGTAATGCCAGCATTGACTGAATTTTAGCCAGATTTTATATTT
ATTTCTGCCGGATTTGATTCAGCAGCTAACGATAAACTAGGTAGGTGCTAATTGACAAAT
ATAGGATACGAATATATGAGTTCAAGACTAGTATAAATATTTCCTAATTTATTGTTTGTT
TTAGAAGGTGGATATAACCTTGATAGCATATAATGGGCATCAGAAGCTGTTATTAGGAGA
ATTTTGGATCCTTTAAACGAAAAATAACTTGAAAGTTTGAGAAATAACATACTGCCAAAC
TAGATGTCAATAAAAGTAATTAATGAATGTAAGCTGGCTCATAATAAATTTTGGAAATTA
CAAGACAAATACAACATTACAAACATCATAGAAAAAAATTAATTTTTTGGAAAAAGTATA
ATATCAGATTTTAGTAAAAACTTTAAGATAGACAACTTCAATGATAAATTATATTACACT
TTAAATTAAATTGAGATTTAATATTTAGAGAAACCTGAGTTTAGGTAGCTACTTTGGCAT
GGAAATTAAATGAAATAGTTTGGAAATGAAATGCTATTTGAAATTTAAAAAAGTATTGAT
GTGGGTTTTGAGATAAAGATAGTAGGTGAGGATAGTATTATCATAAAAGGAATAAAAACA
AAAGATTTTGAAAATAGATAATTAGATGTAATAAATTAAACAATTCAATATCAATAAAAG
GTTTTTGAACATTTTACAGAATAATTAAAAGAAAAAAAACAAATTATTTATGATTCTATT
AAAAACTAATTAAAAGAAATTTCAAATATTCCAATAAATTCACAGCTAATAATTGATGGA
AGTAATTGCTAAGTGATAATCTCGCACATACCAAACAACAATAGCAATCTGATAAATATC
TAATAAATTTGTGAATAATTATCCTCTTATTTCTATGATTAGGAGAAAAAGTGA

>TTHERM_01014700(gene)
TTATTGTTTAACAATAATTCTGCAAGTTTTTAATCCACAAAGTAAAAAAGGTTGCTAAAA
TTACAAAATAATAGTATTATTTATTTCTGTTAAATATAATACATCAAGCTAATATAAATA
AATGATGGATGCCAAGGATAAAAAAGTAGGATTTATATATGATGAAAGAATGCTTTTACA
TAAACTCTCTAAGTAGCCTCCTCATCCTGAGTGCCCTGAAAGAATAGAAAAAATAATAGA
AAACTTAAAAAAAACTGGATTATGGAGTTAATTAGATGTAATTAACTAGGTAGAGCCAAT
TTAAAAAGATATTTTAAATAAAGTGCACAGAGATTCATATGTAGATTTAGTAGAATAAAT
GTGGCCTGAAGGCTGTGAAAAAGAAAACATGGTTTTAAATGGATGTTATTATAATAAGTA
CACAGGATAAAGTGCTTTTTTGTCATCAGGTGCTGTAATTTAATCAATAGATTTGATCAA
ATCCAAATCTTGGCATACTGCTTTTTGTTGTGTTAGACCGCCTGGACATCACAGTGGAGC
TTCATAGTAGTGTAGTGGATTTTGTTTCTTTAACAATGTTGTTGTGGGAGCCAAGTATTT
AAGAGAAAAATATTCAGTCAAAAAAATAGCAATTTTCGATTTTGATGTACATCATGGAGA
CGGAACTCAAGCTCTTACATACGATGATCATGAATTGTTATTTATAAGTATACATTAGTA
TGATGAAGGAAAATTTTATCCTTTCTAAAGTGGAGATTTAAGTAAAGTAGGAAATGGATT
TAACATTAATATTGGTTGGAACACTTCAAATTTTTAAAGTGCTGGAGATGATGAATACAT
TTATGCTTTTGAATCAATTGTAATGCCAGCATTGACTGAATTTTAGCCAGATTTTATATT
TATTTCTGCCGGATTTGATTCAGCAGCTAACGATAAACTAGGTAGGTGCTAATTGACAAA
TATAGGATACGAATATATGAGTTCAAGACTAGTATAAATATTTCCTAATTTATTGTTTGT
TTTAGAAGGTGGATATAACCTTGATAGCATATAATGGGCATCAGAAGCTGTTATTAGGAG
AATTTTGGATCCTTTAAACGAAAAATAACTTGAAAGTTTGAGAAATAACATACTGCCAAA
CTAGATGTCAATAAAAGTAATTAATGAATGTAAGCTGGCTCATAATAAATTTTGGAAATT
ACAAGACAAATACAACATTACAAACATCATAGAAAAAAATTAATTTTTTGGAAAAAGTAT
AATATCAGATTTTAGTAAAAACTTTAAGATAGACAACTTCAATGATAAATTATATTACAC
TTTAAATTAAATTGAGATTTAATATTTAGAGAAACCTGAGTTTAGGTAGCTACTTTGGCA
TGGAAATTAAATGAAATAGTTTGGAAATGAAATGCTATTTGAAATTTAAAAAAGTATTGA
TGTGGGTTTTGAGATAAAGATAGTAGGTGAGGATAGTATTATCATAAAAGGAATAAAAAC
AAAAGATTTTGAAAATAGATAATTAGATGTAATAAATTAAACAATTCAATATCAATAAAA
GGTTTTTGAACATTTTACAGAATAATTAAAAGAAAAAAAACAAATTATTTATGATTCTAT
TAAAAACTAATTAAAAGAAATTTCAAATATTCCAATAAATTCACAGCTAATAATTGATGG
AAGTAATTGCTAAGTGATAATCTCGCACATACCAAACAACAATAGCAATCTGATAAATAT
CTAATAAATTTGTGAATAATTATCCTCTTATTTCTATGATTAGGAGAAAAAGTGATAAAG
AATATTAAAAATAAAATTATAATTAAAGTTTATCAATCTTTTTGATCAATTTAAACTTAA
AAAAAAATCATTTCTTATTATAAGTAAAGTATTTGTTAATATTTTAAATTAAATAGTCTC
GAATTAATACAACTTGAGGAATATAATAAGTGTTAAAAGTATAAATTCTCATTGTAAACT
TTTTAATTAATAATCAATCAATCATAACAATATTTTAATAATTA

>TTHERM_01014700(protein)
MMDAKDKKVGFIYDERMLLHKLSKQPPHPECPERIEKIIENLKKTGLWSQLDVINQVEPI
QKDILNKVHRDSYVDLVEQMWPEGCEKENMVLNGCYYNKYTGQSAFLSSGAVIQSIDLIK
SKSWHTAFCCVRPPGHHSGASQQCSGFCFFNNVVVGAKYLREKYSVKKIAIFDFDVHHGD
GTQALTYDDHELLFISIHQYDEGKFYPFQSGDLSKVGNGFNINIGWNTSNFQSAGDDEYI
YAFESIVMPALTEFQPDFIFISAGFDSAANDKLGRCQLTNIGYEYMSSRLVQIFPNLLFV
LEGGYNLDSIQWASEAVIRRILDPLNEKQLESLRNNILPNQMSIKVINECKLAHNKFWKL
QDKYNITNIIEKNQFFGKSIISDFSKNFKIDNFNDKLYYTLNQIEIQYLEKPEFRQLLWH
GNQMKQFGNEMLFEIQKSIDVGFEIKIVGEDSIIIKGIKTKDFENRQLDVINQTIQYQQK
VFEHFTEQLKEKKQIIYDSIKNQLKEISNIPINSQLIIDGSNCQVIISHIPNNNSNLINI
QQICEQLSSYFYDQEKK