Identifiers and Description

Gene Model Identifier

TTHERM_01018420

Standard Name

THD8 (Tetrahymena Histone Deacetylase 8)

Aliases

PreTt27759 | 199.m00052

Description

THD8 SIR2 family transcriptional regulator; Sir2-like histone deacetylase; suppresses DNA transcription by deacetylation of histones

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (IEA) | GO:0016811
• NAD+ binding (IEA) | GO:0070403
• zinc ion binding (IEA) | GO:0008270

Biological Process

• chromatin silencing (IEA) | GO:0006342
• protein deacetylation (IEA) | GO:0006476
• regulation of transcription (IEA) | GO:0045449

Domains

• ( PF00098 ) Zinc knuckle
• ( PF02146 ) Sir2 family

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_01121.1	9.997093137033517e-262
	Description: transcriptional regulator, Sir2 family protein (386 aa)
Oxytricha	Contig19063.0.g74	4.999450098932641e-139
	Description: Sir2 family
Stentor Coeruleus	SteCoe_10597	2.8946403116483003e-63
	Description: None
WormBase	WBGene00004803	3.0000451088882257e-25
	Description: locus:sir-2.4 NAD-dependent protein deacetylase sir-2.4 status:Confirmed UniProt:Q95Q89 protein_id:CCD61225.1
WormBase	WBGene00001785	3.0000451088882257e-25
	Description: locus:gst-37 status:Partially_confirmed UniProt:Q9BPM4 protein_id:CCD74297.1
DictyBase	DDB_G0283917	8.997498379799854e-17
	Description: sir2A on chromosome: 4 position 1272110 to 1273864
SGD	YPL015C	0.0000000000000030004923591262316
	Description: HST2 Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro

General Information

No Data fetched for General Information

Associated Literature

1. Ref:18178773: Smith JJ, Torigoe SE, Maxson J, Fish LC, Wiley EA (2008) A class II histone deacetylase acts on newly synthesized histones in Tetrahymena. Eukaryotic cell 7(3):471-82

Sequences

>TTHERM_01018420(coding)
ATGAATACAGCTCATAAAACAGACGATGAAAAAAAGGAATTCTTTGATTCACCTAAAGAA
TTAGAAGAAAAAGTAAATATTTTAGTTGATATGATAAAACGTTCTGAGCACTTTGTTGCT
TTTACAGGTGCAGGTATTTCTACTTCTACTGGAATTCCAGATTTTAGAAGTGGTATCAAT
ACAGTACTTCCAACTGGTCCAGGTGCATGGGAAAAATTAGCTTAAAAGACAGGCAGCTCT
AAAAGTAATGTAAAAGTAAGCATGTCTAAGGCAATACCATCTCCTACTCATATGTCTCTT
GTTGAATTACAGAGATAAGGATATCTTAAATTTTTGATAAGTTAGAATGTAGATGGTTTA
CACAGAAGAAGTGGATTTTCTACTTACCACTTAGCCGAATTGCATGGCAACACAAATCTA
GAAAAATGCTAGAAGTGTGGCAAAGAATACATGAGAGATTTTAGAGTCAGAACAGCCCAA
TAAGTACATGATCATAAAACTGGTAGAAAGTGTGATAATTAATAATGTAACGGAGATCTA
TATGACTCTATTATAAATTTTGGTGAAAACCTCCCTGAAAAAGACTAAGATGATGGATTC
GTTCATTCTTAGTTGGCTGATTTGCATTTAGTTTTAGGAAGCAGTTTAAGAGTAACTCCT
GCAGCTGATATGCCTGAAACTACAGCAAAATTAGGAAAAAATTTAGTTATTGTTAATTTG
TAAAAGACTCCTCTTGATTCTTTAGCTACTCTCAGAATAAATGCCATGTGTGATGATGTT
ATGAAAATGGTTATGAAAAAGCTTAAAATAGAAATCCCAGAATTTATCTTAGAAAGAAGG
ATAGTCCTTTAAAAGGGAGATAAAAACAGTTTACTTGTTTCTGCAGAAGATTCAAATGAA
AGTCCTTATGAAATATATAAAAAAGTTACAATTGAATATGGAAAAGCAAACGAAGCTAAA
TAAAAAGCTCCTTTCAATTTCACCCCCAAGCAAAACCAATTCACAGTGAGTTTAGGTTTC
TATGAACATTATGGAGAGTAAGAATTCAAATTAGATGTTGATATGATAGCTTTACCACTC
AATAAAAAAGTGGTTTACTAAATATAATATTAAGTTAGTCTCTAAAAATGGATAAGCTGC
AAACAAATATGA

>TTHERM_01018420(gene)
ATGAATACAGCTCATAAAACAGACGATGAAAAAAAGGAATTCTTTGATTCACCTAAAGAA
TTAGAAGAAAAAGTAAATATTTTAGTTGATATGATAAAACGTTCTGAGCACTTTGTTGCT
TTTACAGGTGCAGGTATTTCTACTTCTACTGGAATTCCAGATTTTAGAAGTGGTATCAAT
ACAGTACTTCCAACTGGTCCAGGTGCATGGGAAAAATTAGCTTAAAAGACAGGCAGCTCT
AAAAGTAATGTAAAAGTAAGCATGTCTAAGGCAATACCATCTCCTACTCATATGTCTCTT
GTTGAATTACAGAGATAAGGATATCTTAAATTTTTGATAAGTTAGAATGTAGATGGTTTA
CACAGAAGAAGTGGATTTTCTACTTACCACTTAGCCGAATTGCATGGCAACACAAATCTA
GAAAAATGCTAGAAGTGTGGCAAAGAATACATGAGAGATTTTAGAGTCAGAACAGCCCAA
TAAGTACATGATCATAAAACTGGTAGAAAGTGTGATAATTAATAATGTAACGGAGATCTA
TATGACTCTATTATAAATTTTGGTGAAAACCTCCCTGAAAAAGACTAAGATGATGGATTC
GTTCATTCTTAGTTGGCTGATTTGCATTTAGTTTTAGGAAGCAGTTTAAGAGTAACTCCT
GCAGCTGATATGCCTGAAACTACAGCAAAATTAGGAAAAAATTTAGTTATTGTTAATTTG
TAAAAGACTCCTCTTGATTCTTTAGCTACTCTCAGAATAAATGCCATGTGTGATGATGTT
ATGAAAATGGTTATGAAAAAGCTTAAAATAGAAATCCCAGAATTTATCTTAGAAAGAAGG
ATAGTCCTTTAAAAGGGAGATAAAAACAGTTTACTTGTTTCTGCAGAAGATTCAAATGAA
AGTCCTTATGAAATATATAAAAAAGTTACAATTGAATATGGAAAAGCAAACGAAGCTAAA
TAAAAAGCTCCTTTCAATTTCACCCCCAAGCAAAACCAATTCACAGTGAGTTTAGGTTTC
TATGAACATTATGGAGAGTAAGAATTCAAATTAGATGTTGATATGATAGCTTTACCACTC
AATAAAAAAGTGGTTTACTAAATATAATATTAAGTTAGTCTCTAAAAATGGATAAGCTGC
AAACAAATATGA

>TTHERM_01018420(protein)
MNTAHKTDDEKKEFFDSPKELEEKVNILVDMIKRSEHFVAFTGAGISTSTGIPDFRSGIN
TVLPTGPGAWEKLAQKTGSSKSNVKVSMSKAIPSPTHMSLVELQRQGYLKFLISQNVDGL
HRRSGFSTYHLAELHGNTNLEKCQKCGKEYMRDFRVRTAQQVHDHKTGRKCDNQQCNGDL
YDSIINFGENLPEKDQDDGFVHSQLADLHLVLGSSLRVTPAADMPETTAKLGKNLVIVNL
QKTPLDSLATLRINAMCDDVMKMVMKKLKIEIPEFILERRIVLQKGDKNSLLVSAEDSNE
SPYEIYKKVTIEYGKANEAKQKAPFNFTPKQNQFTVSLGFYEHYGEQEFKLDVDMIALPL
NKKVVYQIQYQVSLQKWISCKQI