Identifiers and Description

Gene Model Identifier

TTHERM_01018450

Standard Name

THD12 (Tetrahymena Histone Deacetylase 12)

Aliases

PreTt27762 | 199.m00055

Description

THD12 SIR2 family transcriptional regulator; Sir2-like histone deacetylase; suppresses DNA transcription by deacetylation of histones; homolog of Mus muscalus SIRT6

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (IEA) | GO:0016811
• NAD+ binding (IEA) | GO:0070403
• zinc ion binding (IEA) | GO:0008270

Biological Process

• chromatin silencing (IEA) | GO:0006342
• protein deacetylation (IEA) | GO:0006476
• regulation of transcription (IEA) | GO:0045449

Domains

• ( PF02146 ) transcriptional regulator, Sir2 family

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_01119.1	9.997093137033517e-262
	Description: transcriptional regulator, Sir2 family protein (387 aa)
Oxytricha	Contig19063.0.g74	1.0001788721085356e-149
	Description: Sir2 family
Stentor Coeruleus	SteCoe_10597	1.9503933001302485e-65
	Description: None
WormBase	WBGene00004803	3.0010664139725277e-29
	Description: locus:sir-2.4 NAD-dependent protein deacetylase sir-2.4 status:Confirmed UniProt:Q95Q89 protein_id:CCD61225.1
DictyBase	DDB_G0283917	5.998633383648922e-18
	Description: sir2A on chromosome: 4 position 1272110 to 1273864
SGD	YPL015C	0.00000000000004998767099442072
	Description: HST2 Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro

General Information

No Data fetched for General Information

Associated Literature

1. Ref:18178773: Smith JJ, Torigoe SE, Maxson J, Fish LC, Wiley EA (2008) A class II histone deacetylase acts on newly synthesized histones in Tetrahymena. Eukaryotic cell 7(3):471-82

Sequences

>TTHERM_01018450(coding)
ATGGATACTGCACACAAAACAGAAGATGAAAAAAAGGAATACTTCGATGCTCCTGATGTT
TTAGAATAAAAGGTTACTCTTTTAGCTGAAATGATTAAAACTTCAAAGCACTTTGTAGCT
TTCACAGGAGCAGGAATTTCTACTTCTACAGGAATTCCTGATTTTAGAAGTGGAATTAAC
ACTGTTCTTCCTACTGGACCAGGAGCTTGGGAGAAATTAGCCTAAAAAGTTGATAATAAG
CATAAAAATATCAAGACTAGCATGTTGAAAGCTATTCCTTCACCCACACATATGGCTTTG
GTTTAGTTACAAAAAATAGGTTATTTGAAATTCCTTATTAGCTAAAATGTAGACGGATTG
CACAGAAGAAGTGGTTTCTCACCCTAACACTTAGCTGAATTGCATGGCAATACAAATCTT
GAAAAATGTAAAAAATGTGGCAAAGAATACTTGAGAGATTTTAGAGTTAGAAATGCATAG
AAAGTTCATGATCACAAAACAGGTAGAAAGTGCAGCGATTAAAAATGCAAAGGAGATCTT
TATGACTCTATTATAAATTTTGGTGAAAATTTACCTGAAAAAGATTTAAATGAAGGATTT
GCTTAATCAAAAAAATCTGATTTGCATTTGGTTTTAGGAAGTAGTTTAAGAGTAACACCT
GCTGCAGACATGCCTGCCACCACTGCAGAAAAAGGTCAAAAATTAGTTATAATAAACTTG
CAAAAAACTCCTTTAGACTCAGTAGCTACTCTCAGAATAAATGCTATGTGTGATGATGTT
ATGAAAATGGTTATGAAAAAACTTGGATTAGATATACCAGAATTCACTCTTGAAAGAAGA
GTTGTCTTAGAAAAAACAGGTATGAATGCCTTAACAGTTTCAAGCTAAGACTCGGACGAT
TCCCCCTATGATTTGTTTAAATAAATTAAAGTAGATTACGGCAAAATACATCCTGAATAA
ACTTTACTTAAGGCTCCATTCAATATCATACCAAAAAATAAAACATTCTCTCTAAATTTA
AGCTTTTATGGACACTATGGCGAGCAAGATTTTAACTTAAATATCGATATGGCTGCTCTC
TCCATTAATAAAAAAGTGAAATATTTAATACAATATTCACCAAAAGAATAAAAATGGATT
AGTTGCAAAGAAATATGA

>TTHERM_01018450(gene)
ATGGATACTGCACACAAAACAGAAGATGAAAAAAAGGAATACTTCGATGCTCCTGATGTT
TTAGAATAAAAGGTTACTCTTTTAGCTGAAATGATTAAAACTTCAAAGCACTTTGTAGCT
TTCACAGGAGCAGGAATTTCTACTTCTACAGGAATTCCTGATTTTAGAAGTGGAATTAAC
ACTGTTCTTCCTACTGGACCAGGAGCTTGGGAGAAATTAGCCTAAAAAGTTGATAATAAG
CATAAAAATATCAAGACTAGCATGTTGAAAGCTATTCCTTCACCCACACATATGGCTTTG
GTTTAGTTACAAAAAATAGGTTATTTGAAATTCCTTATTAGCTAAAATGTAGACGGATTG
CACAGAAGAAGTGGTTTCTCACCCTAACACTTAGCTGAATTGCATGGCAATACAAATCTT
GAAAAATGTAAAAAATGTGGCAAAGAATACTTGAGAGATTTTAGAGTTAGAAATGCATAG
AAAGTTCATGATCACAAAACAGGTAGAAAGTGCAGCGATTAAAAATGCAAAGGAGATCTT
TATGACTCTATTATAAATTTTGGTGAAAATTTACCTGAAAAAGATTTAAATGAAGGATTT
GCTTAATCAAAAAAATCTGATTTGCATTTGGTTTTAGGAAGTAGTTTAAGAGTAACACCT
GCTGCAGACATGCCTGCCACCACTGCAGAAAAAGGTCAAAAATTAGTTATAATAAACTTG
CAAAAAACTCCTTTAGACTCAGTAGCTACTCTCAGAATAAATGCTATGTGTGATGATGTT
ATGAAAATGGTTATGAAAAAACTTGGATTAGATATACCAGAATTCACTCTTGAAAGAAGA
GTTGTCTTAGAAAAAACAGGTATGAATGCCTTAACAGTTTCAAGCTAAGACTCGGACGAT
TCCCCCTATGATTTGTTTAAATAAATTAAAGTAGATTACGGCAAAATACATCCTGAATAA
ACTTTACTTAAGGCTCCATTCAATATCATACCAAAAAATAAAACATTCTCTCTAAATTTA
AGCTTTTATGGACACTATGGCGAGCAAGATTTTAACTTAAATATCGATATGGCTGCTCTC
TCCATTAATAAAAAAGTGAAATATTTAATACAATATTCACCAAAAGAATAAAAATGGATT
AGTTGCAAAGAAATATGA

>TTHERM_01018450(protein)
MDTAHKTEDEKKEYFDAPDVLEQKVTLLAEMIKTSKHFVAFTGAGISTSTGIPDFRSGIN
TVLPTGPGAWEKLAQKVDNKHKNIKTSMLKAIPSPTHMALVQLQKIGYLKFLISQNVDGL
HRRSGFSPQHLAELHGNTNLEKCKKCGKEYLRDFRVRNAQKVHDHKTGRKCSDQKCKGDL
YDSIINFGENLPEKDLNEGFAQSKKSDLHLVLGSSLRVTPAADMPATTAEKGQKLVIINL
QKTPLDSVATLRINAMCDDVMKMVMKKLGLDIPEFTLERRVVLEKTGMNALTVSSQDSDD
SPYDLFKQIKVDYGKIHPEQTLLKAPFNIIPKNKTFSLNLSFYGHYGEQDFNLNIDMAAL
SINKKVKYLIQYSPKEQKWISCKEI