Identifiers and Description

Gene Model Identifier

TTHERM_01109940

Standard Name

PMS2 (Post-Meiotic Segregation 2 homolog)

Aliases

PreTt17964 | 239.m00043 | 3802.m00184

Description

PMS2 DNA mismatch repair protein; DNA mismatch repair protein; C-terminal domain containing protein; homolog of human PMS2

Genome Browser (Macronucleus)

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Genome Browser (Micronucleus)

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Gene Ontology Annotations

Molecular Function

Biological Process

  • cocaine biosynthetic process (IDA) | GO:0050799
  • obsolete protein-FMN linkage via 1'-(8alpha-FMN)-L-histidine (IEA) | GO:0050743
  • photosynthetic electron transport in photosystem II (IEA) | GO:0009772

Domains

No Data fetched for Domains

Gene Expression Profile

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source Identifier Score
Tetrahymena borealis EI9_20519.1 9.997093137033517e-262
Description: DNA mismatch repair protein domain-containing protein (977 aa)
SGD YNL082W 4.000820122464668e-47
Description: PMS1 ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL
WormBase WBGene00004064 3.0009061039838537e-46
Description: locus:pms-2 status:Confirmed UniProt:G5EFG5 protein_id:CAA18355.1
DictyBase DDB_G0283981 5.998312950603665e-35
Description: pms1 on chromosome: 4 position 1418066 to 1421134
Oxytricha Contig14864.0.g42 1.9991517704232713e-32
Description: DNA mismatch repair protein, C-terminal domain
Stentor Coeruleus SteCoe_12258 2.3195228302435696e-16
Description: None

General Information

No. Gene Name(s) Paragraph Text
100 PMS2 TTHERM_01109940 is a close homologs to budding yeast MutL family member, MLH3. TTHERM_01109940p is the first candidate in a BLAST search with Mlh3 as bait, but it is the best hit in a reciprocal BLAST search with Pms1. It is also the best hit with Mlh2 as bait. TTHERM_00127000p is the best hit in a reciprocal BLAST search with Mlh1. Altogether, it is likely that TTHERM_00127000p is the ortholog of Mlh1, whereas TTHERM_01109940p could be any of Pms1, Mlh2 or Mlh3, but an unambiguous assignment is not possible

Associated Literature

  1. Ref:23935123: Lukaszewicz A, Howard-Till RA, Loidl J (2013) Mus81 nuclease and Sgs1 helicase are essential for meiotic recombination in a protist lacking a synaptonemal complex. Nucleic acids research 41(20):9296-309

Sequences 

>TTHERM_01109940(coding)
ATGATATGTAGAAAATTAAAACTTAATACTTAAATAATATCTTTAATTAATTTCAGAAAC
AAAAAATTCATCAAAAAGCAAGTTGAATTCTCTTAAAATCAAACAAATAAGGATTACATT
AGTATTAAAAAACAGAGTTTTCATATCTAAATGATAAAGAAGCTTGACTAAAGCTCAATC
TTAAATATATGTGTCAATTAAGTTATCATAGATCTAGCTACATGTGTTAAGGAGTTGGTT
GAAAACAGTCTAGATGCTGGATCAACAAAAATAGAAGTGTATCTCAAAGAATATGGAAAG
GAGGGAGTTGAAGTTGTTGACAACGGGAGTGGTATCAGCTCTTAAAATTTAGAATAAATA
GCTTAGAAAGGTGCAACCAGTAAGCTTCGCTAATTTTAGGATCTTGAAAGTCTAGATACC
TTTGGTTTTAGAGGAGAAGCCCTTAATGCAATAAGTGTTTTAAGTTAACTAACTATCACA
ACTAAGACAGACAGTGATGAAATGGCATACCGTTACTAGTTTAATTAAGATAATACAATT
AAATCAAAGACATTAGTGCCTAGAGAAAGAGGGACTACAATTAGTTTAACAGATTTGTTT
GGTAATATCCCAGTTAGAAAATAAGAATTCAACAAAAATATTATTAGTTAATATAATAAA
TTAGTCAATATGATAACTGAATATGCAATTATTTCTGTTAACTGTTAGATTTGTTTGATC
AATTAATCTTCAAAAAAAGGCAGGGAAATGATTTTGAATTCTGGCTCTCCTATGAAAAAT
ATGCTTTAGAAGACTGCTCAAGTATTCTCAAAAAAAATTTCTGATATGCTTGTTGATTTA
AAATTCGATTTCGGTGAAGAATGTAGTGTAATAGAGGGTTATATATTAAATAGATAGACA
AGTGGTAGTGTTTAAGATTCAAAATCAATATAAAAAAATATGAGTTATCTGTTTGTAAAT
ACTCGCCCAGTGAATCCCTTTAAAAAAATGAACTCTATATTTTCAGATATTTATAAAAAA
TACAATAGTTCAGCTAGATATATCTACATTCTTCATTTAAAAGTGAAGAAAGATGCTATT
GATTTTAATGTTTCGCCAGATAAAAGAGATATTTTTATTAAATATGAAAATGAATTTTAT
ACAGCATTAAGAGATAATTTAACATAGCTATTTGAAAAACTCAATAGTATATAAAAGGTT
TTAATGCCTGTGGTGATTTCTAGCAAAATAAAAGATACATCTATGGATGATTCAGAAGAT
GATAGCTAAGAATCTTCAAATTAACAAAAATAAAAAACTTTATCTACTTAGCAAACTAAA
TAGACAAAATTATTTTAAAAATTAAAATAAGAAATTAATATACAAGAGGAGGATTTGTCA
AATGAAGATAGTGAAGCTAATAATTAAAAAGAATTAGAAATTTTATCATTTAAATCTCCT
TCAAAAGGCAAATAAATTACATAACTGAAAGATACTATCAATAATTAAAGAATTGGTAGC
AGTAACTCGAAAAGAAAATAGGATTTATTTGAGGATGTTAATGACGAAATTGAGGATTTA
AGTAATTTTTCAAGTAATAGCAAAGCTCAAAGCAAACAAAAAAATGATAATAGTGAATAC
TTTAAAAGTAGAAACCAAACTTTTAATTCCGATTATTTTAGTATTGCTTAACAAAGGAAG
AAAGCTTATGAAGAATAATTGTAAAATACAAGAGAAGAATTATAAAATAGTAAAGAAGAA
TATTAAGAAAATTATTAGAAAAAATAGTAAACTTCAAGCAAGGATCATAATAATTAAAAT
AAAACTGATTCTAAATAGCTAATTAATGAAGATGAAGAATAAAATTAAGATTTTTCTTAT
TTCAATGATAAATTAAAATTGTATAAGCAATCAAAATAGTAATCAGAAAATAATTCTAAA
TATTAAGTGAAAGAATATTCTTTTGATATGTTTAAAAAATCGAAATAGGAAAATTCAAGT
AAAGGATAAGATAATTAGAAAATTAATAATGAAGATGAAGAAAATTGTGATGATTAATGT
TGCACACAATCACAGAATTACTCTAATTCATAAAACGAATATAAATCAGAAGATTCATCT
CTTTATAAAATGAAAGAAGAAAAATAAACAAAATAATTAAAATAGTCTTTAAATTAAGAA
GAGCTTGTATAAAAACATTTTTAAATACAAGAAGAAGCTAGAATTTTAAATAAAAAATAA
AATAATGAATTGATGGAAATTGATGAAAAGATAGACTAAGATTAGGGAAGAGCATTTAAA
ATTAAATCAAAAAAAGAAGATGAAATAGAAGAATTGGCTGATGACTTAGAAGAACAATTA
AAAACTTGGGAAAGCGAAGACTTTAAAAAAGACAAGTTTGTTGAATTATAAATTATAGGC
TAGTTTAATAAGGCATTTATCATAGCTTATTGGGTTGAAAAAGATTAAATATTTTTAATT
GATTAGCATGCTTCTGATGAAAAGACTAATTATGAAAGATTGTTAAAAGAAAATAATTTC
TAAGGATAAAAACTAGTTAAACCAATAGAGCTAAGCTTAACAATACAAGAAGCAGACATT
TTAGAAAACAATAGGGAAATATTTAAAAAGAACGGTTTTTAATTCTAAATCAAATATGAT
GAAAGCAATGGAGAACCTAACCTTTACATAAACTAACTTCCCTCAAGCAAGCACATTTAA
TTTAATATAAACGATTTCGATGAAATCTTTTAAAACATAAATAATGAAGAAACAGATATT
GAAACATTTAGGCCTAAAAAAATTTAAAGAATTCTTGCTTCTAAGGCTTGTAGATCTTCA
ATTATGATAGGAACAGCCTTAAATAAGTCATCAATGAAATAAATTTTGTTAAATTTATCT
AAGTTGTAATCACCTTGGAATTGCCCTCATGGACGTCCTACTATGGTTAAAACTCCTCCT
ATGAATCATCTCATACAATAAGTTTAAGTCAAAAAGACATATGATCTTTGA


>TTHERM_01109940(gene)
ATGATATGTAGAAAATTAAAACTTAATACTTAAATAATATCTTTAATTAATTTCAGAAAC
AAAAAATTCATCAAAAAGCAAGTTGAATTCTCTTAAAATCAAACAAATAAGGATTACATT
AGTATTAAAAAACAGAGTTTTCATATCTAAATGATAAAGAAGCTTGACTAAAGCTCAATC
TTAAATATATGTGTCAATTAAGTTATCATAGATCTAGCTACATGTAATATTTCTAAATTT
AATTTGAAGAATAATTTAAATTACTTTTTTTACAGGTGTTAAGGAGTTGGTTGAAAACAG
TCTAGATGCTGGATCAACAAAAATAGAAGTGTATCTCAAAGAATATGGAAAGGAGGGAGT
TGAAGTTGTTGACAACGGGAGTGGTATCAGCTCTTAAAATTTAGAATAAATAGCTTAGAA
AGGTGCAACCAGTAAGCTTCGCTAATTTTAGGATCTTGAAAGTCTAGATACCTTTGGTTT
TAGAGGAGAAGCCCTTAATGCAATAAGTGTTTTAAGTTAACTAACTATCACAACTAAGAC
AGACAGTGATGAAATGGCATACCGTTACTAGTTTAATTAAGATAATACAATTAAATCAAA
GAGTAATTTTCAATTTAAACACATAAATTAAATTATCATTCATAAAATATATTTTATTGA
AATTATTTTAATTTAACAAGATTTTATTATTTAAATTCTTTAAAATTTTTTTTATTATGA
TGAATAGCATTAGTGCCTAGAGAAAGAGGGACTACAATTAGTTTAACAGATTTGTTTGGT
AATATCCCAGTTAGAAAATAAGAATTCAACAAAAATATTATTAGTTAATATAATAAATTA
GTCAATATGATAACTGAATATGCAATTATTTCTGTTAACTGTTAGATTTGTTTGATCAAT
TAATCTTCAAAAAAAGGCAGGGAAATGATTTTGAATTCTGGCTCTCCTATGAAAAATATG
CTTTAGAAGACTGCTCAAGTATTCTCAAAAAAAATTTCTGATATGCTTGTTGATTTAAAA
TTCGATTTCGGTGAAGAATGTAGTGTAATAGAGGGTTATATATTAAATAGATAGACAAGT
GGTAGTGTTTAAGATTCAAAATCAATATAAAAAAATATGAGTTATCTGTTTGTAAATACT
CGCCCAGTGAATCCCTTTAAAAAAATGAACTCTATATTTTCAGATATTTATAAAAAATAC
AATAGTTCAGCTAGATATATCTACATTCTTCATTTAAAAGTGAAGAAAGATGCTATTGAT
TTTAATGTTTCGCCAGATAAAAGAGATATTTTTATTAAATATGAAAATGAATTTTATACA
GCATTAAGAGATAATTTAACATAGCTATTTGAAAAACTCAATAGTATATAAAAGGTTTTA
ATGCCTGTGGTGATTTCTAGCAAAATAAAAGATACATCTATGGATGATTCAGAAGATGAT
AGCTAAGAATCTTCAAATTAACAAAAATAAAAAACTTTATCTACTTAGCAAACTAAATAG
ACAAAATTATTTTAAAAATTAAAATAAGAAATTAATATACAAGAGGAGGATTTGTCAAAT
GAAGATAGTGAAGCTAATAATTAAAAAGAATTAGAAATTTTATCATTTAAATCTCCTTCA
AAAGGCAAATAAATTACATAACTGAAAGATACTATCAATAATTAAAGAATTGGTAGCAGT
AACTCGAAAAGAAAATAGGATTTATTTGAGGATGTTAATGACGAAATTGAGGATTTAAGT
AATTTTTCAAGTAATAGCAAAGCTCAAAGCAAACAAAAAAATGATAATAGTGAATACTTT
AAAAGTAGAAACCAAACTTTTAATTCCGATTATTTTAGTATTGCTTAACAAAGGAAGAAA
GCTTATGAAGAATAATTGTAAAATACAAGAGAAGAATTATAAAATAGTAAAGAAGAATAT
TAAGAAAATTATTAGAAAAAATAGTAAACTTCAAGCAAGGATCATAATAATTAAAATAAA
ACTGATTCTAAATAGCTAATTAATGAAGATGAAGAATAAAATTAAGATTTTTCTTATTTC
AATGATAAATTAAAATTGTATAAGCAATCAAAATAGTAATCAGAAAATAATTCTAAATAT
TAAGTGAAAGAATATTCTTTTGATATGTTTAAAAAATCGAAATAGGAAAATTCAAGTAAA
GGATAAGATAATTAGAAAATTAATAATGAAGATGAAGAAAATTGTGATGATTAATGTTGC
ACACAATCACAGAATTACTCTAATTCATAAAACGAATATAAATCAGAAGATTCATCTCTT
TATAAAATGAAAGAAGAAAAATAAACAAAATAATTAAAATAGTCTTTAAATTAAGAAGAG
CTTGTATAAAAACATTTTTAAATACAAGAAGAAGCTAGAATTTTAAATAAAAAATAAAAT
AATGAATTGATGGAAATTGATGAAAAGATAGACTAAGATTAGGGAAGAGCATTTAAAATT
AAATCAAAAAAAGAAGATGAAATAGAAGAATTGGCTGATGACTTAGAAGAACAATTAAAA
ACTTGGGAAAGCGAAGACTTTAAAAAAGACAAGTTTGTTGAATTATAAATTATAGGCTAG
TTTAATAAGGCATTTATCATAGCTTATTGGGTTGAAAAAGATTAAATATTTTTAATTGAT
TAGCATGCTTCTGATGAAAAGACTAATTATGAAAGATTGTTAAAAGAAAATAATTTCTAA
GGATAAAAACTAGTTAAACCAATAGAGCTAAGCTTAACAATACAAGAAGCAGACATTTTA
GAAAACAATAGGGAAATATTTAAAAAGAACGGTTTTTAATTCTAAATCAAATATGATGAA
AGCAATGGAGAACCTAACCTTTACATAAACTAACTTCCCTCAAGCAAGCACATTTAATTT
AATATAAACGATTTCGATGAAATCTTTTAAAACATAAATAATGAAGAAACAGATATTGAA
ACATTTAGGCCTAAAAAAATTTAAAGAATTCTTGCTTCTAAGGCTTGTAGATCTTCAATT
ATGATAGGAACAGCCTTAAATAAGTCATCAATGAAATAAATTTTGTTAAATTTATCTAAG
TTGTAATCACCTTGGAATTGCCCTCATGGACGTCCTACTATGGTTAAAACTCCTCCTATG
AATCATCTCATACAATAAGTTTAAGTCAAAAAGACATATGATCTTTGA


>TTHERM_01109940(protein)
MICRKLKLNTQIISLINFRNKKFIKKQVEFSQNQTNKDYISIKKQSFHIQMIKKLDQSSI
LNICVNQVIIDLATCVKELVENSLDAGSTKIEVYLKEYGKEGVEVVDNGSGISSQNLEQI
AQKGATSKLRQFQDLESLDTFGFRGEALNAISVLSQLTITTKTDSDEMAYRYQFNQDNTI
KSKTLVPRERGTTISLTDLFGNIPVRKQEFNKNIISQYNKLVNMITEYAIISVNCQICLI
NQSSKKGREMILNSGSPMKNMLQKTAQVFSKKISDMLVDLKFDFGEECSVIEGYILNRQT
SGSVQDSKSIQKNMSYLFVNTRPVNPFKKMNSIFSDIYKKYNSSARYIYILHLKVKKDAI
DFNVSPDKRDIFIKYENEFYTALRDNLTQLFEKLNSIQKVLMPVVISSKIKDTSMDDSED
DSQESSNQQKQKTLSTQQTKQTKLFQKLKQEINIQEEDLSNEDSEANNQKELEILSFKSP
SKGKQITQLKDTINNQRIGSSNSKRKQDLFEDVNDEIEDLSNFSSNSKAQSKQKNDNSEY
FKSRNQTFNSDYFSIAQQRKKAYEEQLQNTREELQNSKEEYQENYQKKQQTSSKDHNNQN
KTDSKQLINEDEEQNQDFSYFNDKLKLYKQSKQQSENNSKYQVKEYSFDMFKKSKQENSS
KGQDNQKINNEDEENCDDQCCTQSQNYSNSQNEYKSEDSSLYKMKEEKQTKQLKQSLNQE
ELVQKHFQIQEEARILNKKQNNELMEIDEKIDQDQGRAFKIKSKKEDEIEELADDLEEQL
KTWESEDFKKDKFVELQIIGQFNKAFIIAYWVEKDQIFLIDQHASDEKTNYERLLKENNF
QGQKLVKPIELSLTIQEADILENNREIFKKNGFQFQIKYDESNGEPNLYINQLPSSKHIQ
FNINDFDEIFQNINNEETDIETFRPKKIQRILASKACRSSIMIGTALNKSSMKQILLNLS
KLQSPWNCPHGRPTMVKTPPMNHLIQQVQVKKTYDL