Identifiers and Description

Gene Model Identifier

TTHERM_01109940

Standard Name

PMS2 (Post-Meiotic Segregation 2 homolog)

Aliases

PreTt17964 | 239.m00043 | 3802.m00184

Description

PMS2 DNA mismatch repair protein; DNA mismatch repair protein; C-terminal domain containing protein; homolog of human PMS2; DNA mismatch repair protein MutL/Mlh/Pms-like

Genome Browser (Macronucleus)

Full Screen View


Genome Browser (Micronucleus)

Full Screen View

External Links

Gene Ontology Annotations

Cellular Component

Domains

  • ( PF01119 ) DNA mismatch repair protein, C-terminal domain
  • ( PF08676 ) MutL C terminal dimerisation domain
  • ( PF13589 ) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

No Data fetched for Homologs

General Information

No. Gene Name(s) Paragraph Text
2306 PMS2 TTHERM_01109940 is a close homologs to budding yeast MutL family member, MLH3. TTHERM_01109940p is the first candidate in a BLAST search with Mlh3 as bait, but it is the best hit in a reciprocal BLAST search with Pms1. It is also the best hit with Mlh2 as bait. TTHERM_00127000p is the best hit in a reciprocal BLAST search with Mlh1. Altogether, it is likely that TTHERM_00127000p is the ortholog of Mlh1, whereas TTHERM_01109940p could be any of Pms1, Mlh2 or Mlh3, but an unambiguous assignment is not possible

Associated Literature

  1. Ref:23935123: Lukaszewicz A, Howard-Till RA, Loidl J (2013) Mus81 nuclease and Sgs1 helicase are essential for meiotic recombination in a protist lacking a synaptonemal complex. Nucleic acids research 41(20):9296-309

Sequences 

>TTHERM_01109940(coding)
ATGATATGTAGAAAATTAAAACTTAATACTTAAATAATATCTTTAATTAATTTCAGAAAC
AAAAAATTCATCAAAAAGCAAGTTGAATTCTCTTAAAATCAAACAAATAAGGATTACATT
AGTATTAAAAAACAGAGTTTTCATATCTAAATGATAAAGAAGCTTGACTAAAGCTCAATC
TTAAATATATGTGTCAATTAAGTTATCATAGATCTAGCTACATGTGTTAAGGAGTTGGTT
GAAAACAGTCTAGATGCTGGATCAACAAAAATAGAAGTGTATCTCAAAGAATATGGAAAG
GAGGGAGTTGAAGTTGTTGACAACGGGAGTGGTATCAGCTCTTAAAATTTAGAATAAATA
GCTTAGAAAGGTGCAACCAGTAAGCTTCGCTAATTTTAGGATCTTGAAAGTCTAGATACC
TTTGGTTTTAGAGGAGAAGCCCTTAATGCAATAAGTGTTTTAAGTTAACTAACTATCACA
ACTAAGACAGACAGTGATGAAATGGCATACCGTTACTAGTTTAATTAAGATAATACAATT
AAATCAAAGACATTAGTGCCTAGAGAAAGAGGGACTACAATTAGTTTAACAGATTTGTTT
GGTAATATCCCAGTTAGAAAATAAGAATTCAACAAAAATATTATTAGTTAATATAATAAA
TTAGTCAATATGATAACTGAATATGCAATTATTTCTGTTAACTGTTAGATTTGTTTGATC
AATTAATCTTCAAAAAAAGGCAGGGAAATGATTTTGAATTCTGGCTCTCCTATGAAAAAT
ATGCTTTAGAAGACTGCTCAAGTATTCTCAAAAAAAATTTCTGATATGCTTGTTGATTTA
AAATTCGATTTCGGTGAAGAATGTAGTGTAATAGAGGGTTATATATTAAATAGATAGACA
AGTGGTAGTGTTTAAGATTCAAAATCAATATAAAAAAATATGAGTTATCTGTTTGTAAAT
ACTCGCCCAGTGAATCCCTTTAAAAAAATGAACTCTATATTTTCAGATATTTATAAAAAA
TACAATAGTTCAGCTAGATATATCTACATTCTTCATTTAAAAGTGAAGAAAGATGCTATT
GATTTTAATGTTTCGCCAGATAAAAGAGATATTTTTATTAAATATGAAAATGAATTTTAT
ACAGCATTAAGAGATAATTTAACATAGCTATTTGAAAAACTCAATAGTATATAAAAGGTT
TTAATGCCTGTGGTGATTTCTAGCAAAATAAAAGATACATCTATGGATGATTCAGAAGAT
GATAGCTAAGAATCTTCAAATTAACAAAAATAAAAAACTTTATCTACTTAGCAAACTAAA
TAGACAAAATTATTTTAAAAATTAAAATAAGAAATTAATATACAAGAGGAGGATTTGTCA
AATGAAGATAGTGAAGCTAATAATTAAAAAGAATTAGAAATTTTATCATTTAAATCTCCT
TCAAAAGGCAAATAAATTACATAACTGAAAGATACTATCAATAATTAAAGAATTGGTAGC
AGTAACTCGAAAAGAAAATAGGATTTATTTGAGGATGTTAATGACGAAATTGAGGATTTA
AGTAATTTTTCAAGTAATAGCAAAGCTCAAAGCAAACAAAAAAATGATAATAGTGAATAC
TTTAAAAGTAGAAACCAAACTTTTAATTCCGATTATTTTAGTATTGCTTAACAAAGGAAG
AAAGCTTATGAAGAATAATTGTAAAATACAAGAGAAGAATTATAAAATAGTAAAGAAGAA
TATTAAGAAAATTATTAGAAAAAATAGTAAACTTCAAGCAAGGATCATAATAATTAAAAT
AAAACTGATTCTAAATAGCTAATTAATGAAGATGAAGAATAAAATTAAGATTTTTCTTAT
TTCAATGATAAATTAAAATTGTATAAGCAATCAAAATAGTAATCAGAAAATAATTCTAAA
TATTAAGTGAAAGAATATTCTTTTGATATGTTTAAAAAATCGAAATAGGAAAATTCAAGT
AAAGGATAAGATAATTAGAAAATTAATAATGAAGATGAAGAAAATTGTGATGATTAATGT
TGCACACAATCACAGAATTACTCTAATTCATAAAACGAATATAAATCAGAAGATTCATCT
CTTTATAAAATGAAAGAAGAAAAATAAACAAAATAATTAAAATAGTCTTTAAATTAAGAA
GAGCTTGTATAAAAACATTTTTAAATACAAGAAGAAGCTAGAATTTTAAATAAAAAATAA
AATAATGAATTGATGGAAATTGATGAAAAGATAGACTAAGATTAGGGAAGAGCATTTAAA
ATTAAATCAAAAAAAGAAGATGAAATAGAAGAATTGGCTGATGACTTAGAAGAACAATTA
AAAACTTGGGAAAGCGAAGACTTTAAAAAAGACAAGTTTGTTGAATTATAAATTATAGGC
TAGTTTAATAAGGCATTTATCATAGCTTATTGGGTTGAAAAAGATTAAATATTTTTAATT
GATTAGCATGCTTCTGATGAAAAGACTAATTATGAAAGATTGTTAAAAGAAAATAATTTC
TAAGGATAAAAACTAGTTAAACCAATAGAGCTAAGCTTAACAATACAAGAAGCAGACATT
TTAGAAAACAATAGGGAAATATTTAAAAAGAACGGTTTTTAATTCTAAATCAAATATGAT
GAAAGCAATGGAGAACCTAACCTTTACATAAACTAACTTCCCTCAAGCAAGCACATTTAA
TTTAATATAAACGATTTCGATGAAATCTTTTAAAACATAAATAATGAAGAAACAGATATT
GAAACATTTAGGCCTAAAAAAATTTAAAGAATTCTTGCTTCTAAGGCTTGTAGATCTTCA
ATTATGATAGGAACAGCCTTAAATAAGTCATCAATGAAATAAATTTTGTTAAATTTATCT
AAGTTGTAATCACCTTGGAATTGCCCTCATGGACGTCCTACTATGGTTAAAACTCCTCCT
ATGAATCATCTCATACAATAAGTTTAAGTCAAAAAGACATATGATCTTTGA



>TTHERM_01109940(gene)
CATTTACAAGTAAATTATCAAAAACAAATCATTAGAATGATATGTAGAAAATTAAAACTT
AATACTTAAATAATATCTTTAATTAATTTCAGAAACAAAAAATTCATCAAAAAGCAAGTT
GAATTCTCTTAAAATCAAACAAATAAGGATTACATTAGTATTAAAAAACAGAGTTTTCAT
ATCTAAATGATAAAGAAGCTTGACTAAAGCTCAATCTTAAATATATGTGTCAATTAAGTT
ATCATAGATCTAGCTACATGTGTTAAGGAGTTGGTTGAAAACAGTCTAGATGCTGGATCA
ACAAAAATAGAAGTGTATCTCAAAGAATATGGAAAGGAGGGAGTTGAAGTTGTTGACAAC
GGGAGTGGTATCAGCTCTTAAAATTTAGAATAAATAGCTTAGAAAGGTGCAACCAGTAAG
CTTCGCTAATTTTAGGATCTTGAAAGTCTAGATACCTTTGGTTTTAGAGGAGAAGCCCTT
AATGCAATAAGTGTTTTAAGTTAACTAACTATCACAACTAAGACAGACAGTGATGAAATG
GCATACCGTTACTAGTTTAATTAAGATAATACAATTAAATCAAAGACATTAGTGCCTAGA
GAAAGAGGGACTACAATTAGTTTAACAGATTTGTTTGGTAATATCCCAGTTAGAAAATAA
GAATTCAACAAAAATATTATTAGTTAATATAATAAATTAGTCAATATGATAACTGAATAT
GCAATTATTTCTGTTAACTGTTAGATTTGTTTGATCAATTAATCTTCAAAAAAAGGCAGG
GAAATGATTTTGAATTCTGGCTCTCCTATGAAAAATATGCTTTAGAAGACTGCTCAAGTA
TTCTCAAAAAAAATTTCTGATATGCTTGTTGATTTAAAATTCGATTTCGGTGAAGAATGT
AGTGTAATAGAGGGTTATATATTAAATAGATAGACAAGTGGTAGTGTTTAAGATTCAAAA
TCAATATAAAAAAATATGAGTTATCTGTTTGTAAATACTCGCCCAGTGAATCCCTTTAAA
AAAATGAACTCTATATTTTCAGATATTTATAAAAAATACAATAGTTCAGCTAGATATATC
TACATTCTTCATTTAAAAGTGAAGAAAGATGCTATTGATTTTAATGTTTCGCCAGATAAA
AGAGATATTTTTATTAAATATGAAAATGAATTTTATACAGCATTAAGAGATAATTTAACA
TAGCTATTTGAAAAACTCAATAGTATATAAAAGGTTTTAATGCCTGTGGTGATTTCTAGC
AAAATAAAAGATACATCTATGGATGATTCAGAAGATGATAGCTAAGAATCTTCAAATTAA
CAAAAATAAAAAACTTTATCTACTTAGCAAACTAAATAGACAAAATTATTTTAAAAATTA
AAATAAGAAATTAATATACAAGAGGAGGATTTGTCAAATGAAGATAGTGAAGCTAATAAT
TAAAAAGAATTAGAAATTTTATCATTTAAATCTCCTTCAAAAGGCAAATAAATTACATAA
CTGAAAGATACTATCAATAATTAAAGAATTGGTAGCAGTAACTCGAAAAGAAAATAGGAT
TTATTTGAGGATGTTAATGACGAAATTGAGGATTTAAGTAATTTTTCAAGTAATAGCAAA
GCTCAAAGCAAACAAAAAAATGATAATAGTGAATACTTTAAAAGTAGAAACCAAACTTTT
AATTCCGATTATTTTAGTATTGCTTAACAAAGGAAGAAAGCTTATGAAGAATAATTGTAA
AATACAAGAGAAGAATTATAAAATAGTAAAGAAGAATATTAAGAAAATTATTAGAAAAAA
TAGTAAACTTCAAGCAAGGATCATAATAATTAAAATAAAACTGATTCTAAATAGCTAATT
AATGAAGATGAAGAATAAAATTAAGATTTTTCTTATTTCAATGATAAATTAAAATTGTAT
AAGCAATCAAAATAGTAATCAGAAAATAATTCTAAATATTAAGTGAAAGAATATTCTTTT
GATATGTTTAAAAAATCGAAATAGGAAAATTCAAGTAAAGGATAAGATAATTAGAAAATT
AATAATGAAGATGAAGAAAATTGTGATGATTAATGTTGCACACAATCACAGAATTACTCT
AATTCATAAAACGAATATAAATCAGAAGATTCATCTCTTTATAAAATGAAAGAAGAAAAA
TAAACAAAATAATTAAAATAGTCTTTAAATTAAGAAGAGCTTGTATAAAAACATTTTTAA
ATACAAGAAGAAGCTAGAATTTTAAATAAAAAATAAAATAATGAATTGATGGAAATTGAT
GAAAAGATAGACTAAGATTAGGGAAGAGCATTTAAAATTAAATCAAAAAAAGAAGATGAA
ATAGAAGAATTGGCTGATGACTTAGAAGAACAATTAAAAACTTGGGAAAGCGAAGACTTT
AAAAAAGACAAGTTTGTTGAATTATAAATTATAGGCTAGTTTAATAAGGCATTTATCATA
GCTTATTGGGTTGAAAAAGATTAAATATTTTTAATTGATTAGCATGCTTCTGATGAAAAG
ACTAATTATGAAAGATTGTTAAAAGAAAATAATTTCTAAGGATAAAAACTAGTTAAACCA
ATAGAGCTAAGCTTAACAATACAAGAAGCAGACATTTTAGAAAACAATAGGGAAATATTT
AAAAAGAACGGTTTTTAATTCTAAATCAAATATGATGAAAGCAATGGAGAACCTAACCTT
TACATAAACTAACTTCCCTCAAGCAAGCACATTTAATTTAATATAAACGATTTCGATGAA
ATCTTTTAAAACATAAATAATGAAGAAACAGATATTGAAACATTTAGGCCTAAAAAAATT
TAAAGAATTCTTGCTTCTAAGGCTTGTAGATCTTCAATTATGATAGGAACAGCCTTAAAT
AAGTCATCAATGAAATAAATTTTGTTAAATTTATCTAAGTTGTAATCACCTTGGAATTGC
CCTCATGGACGTCCTACTATGGTTAAAACTCCTCCTATGAATCATCTCATACAATAAGTT
TAAGTCAAAAAGACATATGATCTTTGAGACTGAAAATATTTTCAAATAATATAAAAAATA
TCAACAATAATCTAATTTTGTTACTCATTTAAATAAAATTTTAATCTGTCTATATCAATC
ATTATTTATTATCAATATTAATTATTAC



>TTHERM_01109940(protein)
MICRKLKLNTQIISLINFRNKKFIKKQVEFSQNQTNKDYISIKKQSFHIQMIKKLDQSSI
LNICVNQVIIDLATCVKELVENSLDAGSTKIEVYLKEYGKEGVEVVDNGSGISSQNLEQI
AQKGATSKLRQFQDLESLDTFGFRGEALNAISVLSQLTITTKTDSDEMAYRYQFNQDNTI
KSKTLVPRERGTTISLTDLFGNIPVRKQEFNKNIISQYNKLVNMITEYAIISVNCQICLI
NQSSKKGREMILNSGSPMKNMLQKTAQVFSKKISDMLVDLKFDFGEECSVIEGYILNRQT
SGSVQDSKSIQKNMSYLFVNTRPVNPFKKMNSIFSDIYKKYNSSARYIYILHLKVKKDAI
DFNVSPDKRDIFIKYENEFYTALRDNLTQLFEKLNSIQKVLMPVVISSKIKDTSMDDSED
DSQESSNQQKQKTLSTQQTKQTKLFQKLKQEINIQEEDLSNEDSEANNQKELEILSFKSP
SKGKQITQLKDTINNQRIGSSNSKRKQDLFEDVNDEIEDLSNFSSNSKAQSKQKNDNSEY
FKSRNQTFNSDYFSIAQQRKKAYEEQLQNTREELQNSKEEYQENYQKKQQTSSKDHNNQN
KTDSKQLINEDEEQNQDFSYFNDKLKLYKQSKQQSENNSKYQVKEYSFDMFKKSKQENSS
KGQDNQKINNEDEENCDDQCCTQSQNYSNSQNEYKSEDSSLYKMKEEKQTKQLKQSLNQE
ELVQKHFQIQEEARILNKKQNNELMEIDEKIDQDQGRAFKIKSKKEDEIEELADDLEEQL
KTWESEDFKKDKFVELQIIGQFNKAFIIAYWVEKDQIFLIDQHASDEKTNYERLLKENNF
QGQKLVKPIELSLTIQEADILENNREIFKKNGFQFQIKYDESNGEPNLYINQLPSSKHIQ
FNINDFDEIFQNINNEETDIETFRPKKIQRILASKACRSSIMIGTALNKSSMKQILLNLS
KLQSPWNCPHGRPTMVKTPPMNHLIQQVQVKKTYDL