Identifiers and Description

Gene Model Identifier

TTHERM_01169510

Standard Name

HEH2

Aliases

PreTt08260 | 262.m00035 | 3804.m00139

Description

HEH2 cyclic nucleotide-binding domain protein; cyclic nucleotide-binding domain containing protein; protein of unknown function; localizes to basal bodies; expressed during vegetative growth; homolog of human disease gene KIAA1279- implicated in nervous system development and Goldberg-Shprintzen syndrome; no homolog in S. cerevisiae

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• microtubule basal body (TAS) | GO:0005932

Domains

No Data fetched for Domains

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_20340.1	9.997093137033517e-262
	Description: cyclic nucleotide-binding domain-containing protein (1138 aa)
Oxytricha	Contig6878.0.g46	5.997739233660418e-28
	Description: Cyclic nucleotide-binding domain
Stentor Coeruleus	SteCoe_9224	6.305116760146989e-16
	Description: None
SGD	YIL033C	0.0000000020002373268528243
	Description: BCY1 Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
WormBase	WBGene00001173	0.0000000039998859049333245
	Description: locus:egl-4 cGMP-dependent protein kinase egl-4 status:Confirmed UniProt:O76360 protein_id:CCD71859.1

General Information

No.	Gene Name(s)	Paragraph Text
6	HEH2	HEH2 is expressed during vegetative growth of T. thermophila and its protein product has been localized to basal bodies. Interestingly, its protein product was found to have high sequence similarity to the human disease gene KIAA1279. Human KIAA1279 was also found to have homologs in fruit fly, frog, rat, mouse, bee, chicken, and Japanese puffer fish, but none in Saccharomyces cerevisiae. Although the function of KIAA1279 is not yet known, evidence suggests that KIAA1279 is important in the development of the enteric and central nervous system (CNS). KIAA1279 was expressed in different parts of the adult CNS, and mutations in KIAA1279 were associated with Goldberg-Shprintzen syndrome (OMIM).
7	HEH2	HEH2 appears to be located on the right arm of micronuclear chromosome 2 based on mapping REP6, a locus upstream of HEH2.

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_01169510(coding)
ATGAGTGTATAATAGGATAGACTGAATTAAATTATTGAAATTTTAAAAACTCCTTCATCC
CTTAGAGCCGAAGTATAGATAAGTTTCTTGTAGCAAGAGACAAATCATATAGGTCTATTC
AAATAATACAAGGAAGAAGATGGAGATGATGAGCTTTAGAGGCTTTGTTGTATGTATATG
AAGTATGAATATCAATCAAAAGATTAAACTCTATTCAACATAGATGATTTTGGTACCAAG
TTCTATATCATATTATCAGGAAAGGTAGGTGTTTATATTCGCATGCCTAAACAAAAAAGG
TTAGAATTATTTTAGGAATAAAATAACTAAAATAAAGCACATGAGCCAGATCCTTTACAA
ATGGTAAAGGAATTAAGAATGGGAGATTCATTTGGAGAGCTAGCCCTTCTTAAAAATAGT
AAAAGATTAGCTACTATTATATGCAAGGAAGATTGTCATTTTGGTGTCATTGATAAAAAA
ATTTTTAACTTAGCACTCAAAGAAAAGGAAGAAGAAAAACTAAATATTTAAATGAGATTC
TTAGCTAATTCTCCTTTGTTTAGTAGATTGCCAAAAAACACTATTAAGCATCTTCATATG
AATGCGTTTTATGTATAGTACTAAAAAGGTCAACCTGTTTACTTAGAAGGACAAAACTCC
AACTCTTGCTTTGTAATCAAAAGTGGAGAGTTTACTATATATAAAACTATTCAACATGTT
ATGAAGACTCATGAAAAAAAAAACTAATATTTGACAGGTGGAGAGTAAAAAAATTTAGAT
ATTAAAATAAGTGTTTTAGGTAAAGGTGAACTTTTTGGTGAAATTGAATTGATATAAGGA
GATTCACGCTGCACTAGTGCTTTTTGTTCAAGCTTAGATGGAGGAGAGTTAATGATTATT
AACAGGACTGATTTAGAAAATAAAGTTTTATGTGAAGAGGAATATATGCAATAGTTTTAA
AATTATATTAAAATGAAAAAGGAATAGCTAAAAAAGAGAATAGAAGGGATTAAAAATTAG
CTACACAAATACCAAACTTATAGGTTTATGACAAGCGCGTTAAAAATTCATGAAGTAGAT
GTTTGTGAGAAAATAAAAAATAAAGAGCTAAATTACTCAATTGATGTTTTAGATGATGTT
ATTCAGAGTTAAACTGATAAAAATGATGATGATGAAGTAGGAATTTTATCAGCCTAAAAG
TCTTCCAAATTAAAGTAGCTATAACAAGTTTAGAAATATAAACCGAAGTCTAAATCTTCA
ATTAATATTTTGAGCAACACTAATTTAAAATTTTAGAATAATTAGAGTTAAACAAGTCTA
CTAAATTTGGCATCAATAAATGATTTAGCTAATCATGAAGAAAATTCATAATTAAAATCA
TAAAACTCACAATAATAAATCACATAACCTTCTTCACAAGAAAAGTTAAATATAAACAGT
TCTCAGTAAATAAATAATTTTGCTCCTGTGGAAGATAAGAAAATCAATGAAGTAACTGCT
CATATCACTAAAAACTCAAAGGAATAGTTTATGAATAAATGGTTTAAATATGGAGAAGGA
GAAGAAGGTCCATAATAAAGTGAAAATAAATCTAAAAAATAAAAATTATTGAGAGTAGAG
CTGAATTCTTACACTGAATTAAAAAATAGCATCAGAAAAAAAACAGCTATTGCCTTAAGT
AAGCAGTATCGCCTTCCTTATGAAAAATTTATGTATGCTGGAAGCATGTATGACATAAGT
TAAAGCGAAGATTGGATGAAATAATAACAAATGTAACCTTAGTAATAACCAGATACAATT
AACAGGAAGACAATATCTTCTTTATCAAAATTAAGAGTTTAGACATAAGCAACACTAAAT
CATATCTAAACATGCAGACATATGAGCTAAACTGATAATTTCTAAGTAGAAAATTAGTCT
TCTATTCATAAGATTAAGAGTTTAGCATGTTTAGATGCCAAATAAAATCTGAATAATATA
AAATAATAATAAAAACCTGTAATTAAAGAGGATTTTTAACACCTAAAAAGTATCTAGTAA
TTTAGCCTACCTGATGAATAAGCTAAAAACAACTTTTTTAATTCTATTTAAAGAATTTAA
AGCAGTGTCAGCTTAAAATCTTAGGATAGCAAAAATTGGATTAGCAAGTAATAAAAAGAA
AATGATAATTTTAAATCAGAGCTATTGGACAAGCTTTAACAATTTAAATAACATTAATAA
CATTAATAATCATAAAATGATATTCCAAATTTAAAAAAATAAAGTTCAAAAAGTCCAAAA
AAAGACACTGATTTAATTGAAGATGTAAATTTAATGAAGAGCATAGAAGATCATTATAAT
AATAGTCTAACAGAAGAGGGTAGCAAAAAGTACTAAAAGAAACTAAAAAACATTTTAAAG
CTTGATATTCAGCATGAATCTTCTGATAATTCCAGGACAAGCACATCAAATCTCAATACT
CCAAAATTAATTTAAAGCAAAAAAGCTAGCTAAGCATCTCTATTTAATATGAGCTCTTCT
ACAAATTTAAAATCCTAACAAAACTTAGACAATAAGTCCTAGTTTAGTAGTATACCTCTA
AAGAATGCTGAAATTCTTTTTGAAAAATAAGGTAAAAAATTATAAAAAAAGCAACATCTA
AGACTTCATGAAAATAAAGACTCACCTCTTAAGTTTCAATTTTCATAATCCACAAGACAC
TCAATGGCAACAAATTATTTTTAACCAAAAAATTTCGTTGAAGATTAAAACTAACTCCCT
TATTGGGTATAACCACTTAGCACCCAGAATAGTGATTAATAGCAATACTCTAAAAATTAA
ATAATTGATTTTAATAATTAAAATAATTAATCTCTCTCTTAAACATTATCTCCTTAAAAT
TAGAAATAAAAATAATATAAAATGCAATTATCTTCATACTTTAAACCTAAAAATATAAAA
AGTGAATTTGGAGAAGATTTAGAAAAAGAAACATCTTTAATTGATAAGCAATTATCCAAA
GAATAAAATTAATTAACTCTATCTCAGAATAAATAAAAATCCTTCATTTACAAAAACAAC
TCCTCTGCTCATGAGATGAATTAAATTATTTCTATAAAATCCGTAAATAATTTGTCTGAC
TTAAATAATAGAGCAATTTCGTCAGAGAGATAATTTAGATAAAAATAATAAACAAATGGA
AGCAGCAGCTAAAATATATTTTATAAAACATTTCATTAAAATAAAAAAATACTTAAAAAC
ATAGCACCCTACAATAACAAAAAACAAACTTTAGAACAACCTGCAATTTATAAATTTCAA
TAAGATTCTCCTTTAAAAGTTAAAAAATATTAATAACTACTATAACCTTAACAATAGCAA
TACAATTTACTAAATTAAATTCTTTCTACTCCAAAAATTACTAATAACTCTTGA

>TTHERM_01169510(gene)
ATGTATACATATCTTTCTTTTATATTTATAGCTAAAAACTCAATAAATACAGTAAAAAAA
TCTAACACAATTCAAATTAAATAAACTTTTTTAAAACTTTTAGATAAGAAAATTATAAAT
TTAAGAGCTATGATGAAATAATACTTTCACCATTAAAAAAAAATATGCGTTAAAAAAAAT
TTGTATTAAAAAATAAGTAAAAATATGTTCAAAACATATGTTTTTAGAGTATAATATTTA
TTAAAAATAACGAGTGTGAATAATTTAAACTTTTTGAATATTTTTTTATCAACACTAATA
AGATTTTTTAGTAGATTTTGCTATAAAACTAGTAATATTTTGTATTTTTGATCAATTAGC
TACAAAAATCTTTAGGTGCATGGATGCTATTAAGGATTTTTTGATTATGGTATTGTTGTA
ATTAATTACTTTACTTTTAAATCAATTCAAATAGTAACTAAATTTGTTTGTAAAAAGTCA
TATTTTCATCACAAAATTCAGTGAGATAATATTCAGAAATCAATATCAATTAATTAGTAA
TCAAGCAAAACCATAAAATATTACTAAAAATATTAAGATAGGAGTTTTTATTAATCACAT
TTATTTGATAAAAATTTAATATAACAAATTTGCTCAAAAACTAACAGTAAATTAAACTCT
TTGGTAAAAGGATTCAAAGCATTGTGGTGAGCTAAAATTTATATAAGAACAACTTTCGAA
TTTTTATAAAATGAGTGTATAATAGGATAGACTGAATGTAATTTCATATGTTTTTTCTTT
GAAAATAAATGTTTTTCATCAAATATGATGAAAGTTATTTTGTATCATTTTGCTTATTTT
AGTTATGATTATAATTAGTAAATTATTGAAATTTTAAAAACTCCTTCATCCCTTAGAGCC
GAAGTATAGATAAGTTTCTTGTAGCAAGAGACAAATCATATAGGTCTATTCAAATAATAC
AAGGAAGAAGATGGAGATGATGAGCTTTAGAGGCTTTGTTGTATGTATATGAAGTATGAA
TATCAATCAAAAGATTAAACTCTATTCAACATAGGTAATGATTGCTTAAATTATGTTTAA
ACATTAAATGTTTAAGCTTTTATTATTTTTAGTTGCTCATAAATTTTAAATATAATATTT
TTATAGATGATTTTGGTACCAAGTTCTATATCATATTATCAGGAAAGGTAGGTGTTTATA
TTCGCATGCCTAAACAAAAAAGGTTAGAATTATTTTAGGAATAAAATAACTAAAATAAAG
CACATGAGCCAGATCCTTTACAAATGGTAAAGGAATTAAGAATGGGAGATTCATTTGGAG
AGCTAGCCCTTCTTAAAAATAGTAAAAGATTAGCTACTATTATATGCAAGGAAGATTGTC
ATTTTGGTGTCATTGATAAAAAAATTTTTAACTTAGCACTCAAAGAAAAGGAAGAAGAAA
AACTAAATATTTAAATGAGATTCTTAGCTAATTCTCCTTTGTTTAGTAGATTGCCAAAAA
ACACTATTAAGCATCTTCATATGAATGCGTTTTATGTATAGTACTAAAAAGGTCAACCTG
TTTACTTAGAAGGACAAAACTCCAACTCTTGCTTTGTAATCAAAAGTGGAGAGTTTACTG
TAATAATTTTATTACTTCAGTATTTAATCTTAAAAATAAATTATTTTTAAGATTTTTATA
AAAAAAAAGTAGAAATAATATCAAATATTTATATAAAACTTATTAAAAATACAGATATAT
AAAACTATTCAACATGTTATGAAGACTCATGAAAAAAAAAACTAATATTTGACAGGTGGA
GAGTAAAAAAATTTAGATATTAAAGTAATTCAATTATTTTCTATTAAATATATTTATAAT
TTATTTTTTTTAAATGAAAATAAAAGATAAGTGTTTTAGGTAAAGGTGAACTTTTTGGTG
AAATTGAATTGATATAAGGAGATTCACGCTGCACTAGTGCTTTTTGTTCAAGCTTAGATG
GAGGAGAGTTAATGATTATTAACAGGACTGATTTAGAAAATAAAGTTTTATGTGAAGAGG
AATATATGCAATAGTTTTAAAATTATATTAAAATGAAAAAGGAATAGCTAAAAAAGAGAA
TAGAAGGGATTAAAAATTAGCTACACAAATACCAAACTTATAGGTTTATGACAAGCGCGT
TAAAAATTCATGAAGTAGATGTTTGTGAGAAAATAAAAAATAAAGAGCTAAATTACTCAA
TTGATGTTTTAGATGATGTTATTCAGAGTTAAACTGATAAAAATGATGATGATGAAGTAG
GAATTTTATCAGCCTAAAAGTCTTCCAAATTAAAGTAGCTATAACAAGTTTAGAAATATA
AACCGAAGTCTAAATCTTCAATTAATATTTTGAGCAACACTAATTTAAAATTTTAGAATA
ATTAGAGTTAAACAAGTCTACTAAATTTGGCATCAATAAATGATTTAGCTAATCATGAAG
AAAATTCATAATTAAAATCATAAAACTCACAATAATAAATCACATAACCTTCTTCACAAG
AAAAGTTAAATATAAACAGTTCTCAGTAAATAAATAATTTTGCTCCTGTGGAAGATAAGA
AAATCAATGAAGTAACTGCTCATATCACTAAAAACTCAAAGGAATAGTTTATGAATAAAT
GGTTTAAATATGGAGAAGGAGAAGAAGGTCCATAATAAAGTGAAAATAAATCTAAAAAAT
AAAAATTATTGAGAGTAGAGCTGAATTCTTACACTGAATTAAAAAATAGCATCAGAAAAA
AAACAGCTATTGCCTTAAGTAAGCAGTATCGCCTTCCTTATGAAAAATTTATGTATGCTG
GAAGCATGTATGACATAAGTTAAAGCGAAGATTGGATGAAATAATAACAAATGTAACCTT
AGTAATAACCAGATACAATTAACAGGAAGACAATATCTTCTTTATCAAAATTAAGAGTTT
AGACATAAGCAACACTAAATCATATCTAAACATGCAGACATATGAGCTAAACTGATAATT
TCTAAGTAGAAAATTAGTCTTCTATTCATAAGATTAAGAGTTTAGCATGTTTAGATGCCA
AATAAAATCTGAATAATATAAAATAATAATAAAAACCTGTAATTAAAGAGGATTTTTAAC
ACCTAAAAAGTATCTAGTAATTTAGCCTACCTGATGAATAAGCTAAAAACAACTTTTTTA
ATTCTATTTAAAGAATTTAAAGCAGTGTCAGCTTAAAATCTTAGGATAGCAAAAATTGGA
TTAGCAAGTAATAAAAAGAAAATGATAATTTTAAATCAGAGCTATTGGACAAGCTTTAAC
AATTTAAATAACATTAATAACATTAATAATCATAAAATGATATTCCAAATTTAAAAAAAT
AAAGTTCAAAAAGTCCAAAAAAAGACACTGATTTAATTGAAGATGTAAATTTAATGAAGA
GCATAGAAGATCATTATAATAATAGTCTAACAGAAGAGGGTAGCAAAAAGTACTAAAAGA
AACTAAAAAACATTTTAAAGCTTGATATTCAGCATGAATCTTCTGATAATTCCAGGACAA
GCACATCAAATCTCAATACTCCAAAATTAATTTAAAGCAAAAAAGCTAGCTAAGCATCTC
TATTTAATATGAGCTCTTCTACAAATTTAAAATCCTAACAAAACTTAGACAATAAGTCCT
AGTTTAGTAGTATACCTCTAAAGAATGCTGAAATTCTTTTTGAAAAATAAGGTAAAAAAT
TATAAAAAAAGCAACATCTAAGACTTCATGAAAATAAAGACTCACCTCTTAAGTTTCAAT
TTTCATAATCCACAAGACACTCAATGGCAACAAATTATTTTTAACCAAAAAATTTCGTTG
AAGATTAAAACTAACTCCCTTATTGGGTATAACCACTTAGCACCCAGAATAGTGATTAAT
AGCAATACTCTAAAAATTAAATAATTGATTTTAATAATTAAAATAATTAATCTCTCTCTT
AAACATTATCTCCTTAAAATTAGAAATAAAAATAATATAAAATGCAATTATCTTCATACT
TTAAACCTAAAAATATAAAAAGTGAATTTGGAGAAGATTTAGAAAAAGAAACATCTTTAA
TTGATAAGCAATTATCCAAAGAATAAAATTAATTAACTCTATCTCAGAATAAATAAAAAT
CCTTCATTTACAAAAACAACTCCTCTGCTCATGAGATGAATTAAATTATTTCTATAAAAT
CCGTAAATAATTTGTCTGACTTAAATAATAGAGCAATTTCGTCAGAGAGATAATTTAGAT
AAAAATAATAAACAAATGGAAGCAGCAGCTAAAATATATTTTATAAAACATTTCATTAAA
ATAAAAAAATACTTAAAAACATAGCACCCTACAATAACAAAAAACAAACTTTAGAACAAC
CTGCAATTTATAAATTTCAATAAGATTCTCCTTTAAAAGTTAAAAAATATTAATAACTAC
TATAACCTTAACAATAGCAATACAATTTACTAAATTAAATTCTTTCTACTCCAAAAATTA
CTAATAACTCTTGA

>TTHERM_01169510(protein)
MSVQQDRLNQIIEILKTPSSLRAEVQISFLQQETNHIGLFKQYKEEDGDDELQRLCCMYM
KYEYQSKDQTLFNIDDFGTKFYIILSGKVGVYIRMPKQKRLELFQEQNNQNKAHEPDPLQ
MVKELRMGDSFGELALLKNSKRLATIICKEDCHFGVIDKKIFNLALKEKEEEKLNIQMRF
LANSPLFSRLPKNTIKHLHMNAFYVQYQKGQPVYLEGQNSNSCFVIKSGEFTIYKTIQHV
MKTHEKKNQYLTGGEQKNLDIKISVLGKGELFGEIELIQGDSRCTSAFCSSLDGGELMII
NRTDLENKVLCEEEYMQQFQNYIKMKKEQLKKRIEGIKNQLHKYQTYRFMTSALKIHEVD
VCEKIKNKELNYSIDVLDDVIQSQTDKNDDDEVGILSAQKSSKLKQLQQVQKYKPKSKSS
INILSNTNLKFQNNQSQTSLLNLASINDLANHEENSQLKSQNSQQQITQPSSQEKLNINS
SQQINNFAPVEDKKINEVTAHITKNSKEQFMNKWFKYGEGEEGPQQSENKSKKQKLLRVE
LNSYTELKNSIRKKTAIALSKQYRLPYEKFMYAGSMYDISQSEDWMKQQQMQPQQQPDTI
NRKTISSLSKLRVQTQATLNHIQTCRHMSQTDNFQVENQSSIHKIKSLACLDAKQNLNNI
KQQQKPVIKEDFQHLKSIQQFSLPDEQAKNNFFNSIQRIQSSVSLKSQDSKNWISKQQKE
NDNFKSELLDKLQQFKQHQQHQQSQNDIPNLKKQSSKSPKKDTDLIEDVNLMKSIEDHYN
NSLTEEGSKKYQKKLKNILKLDIQHESSDNSRTSTSNLNTPKLIQSKKASQASLFNMSSS
TNLKSQQNLDNKSQFSSIPLKNAEILFEKQGKKLQKKQHLRLHENKDSPLKFQFSQSTRH
SMATNYFQPKNFVEDQNQLPYWVQPLSTQNSDQQQYSKNQIIDFNNQNNQSLSQTLSPQN
QKQKQYKMQLSSYFKPKNIKSEFGEDLEKETSLIDKQLSKEQNQLTLSQNKQKSFIYKNN
SSAHEMNQIISIKSVNNLSDLNNRAISSERQFRQKQQTNGSSSQNIFYKTFHQNKKILKN
IAPYNNKKQTLEQPAIYKFQQDSPLKVKKYQQLLQPQQQQYNLLNQILSTPKITNNS