Identifiers and Description

Gene Model Identifier

TTHERM_01194720

Standard Name

DES5 (C-5(6) sterol DESaturase 5 )

Aliases

PreTt07509 | 270.m00035

Description

ERG3 C-5 sterol desaturase; Catalyzes the introduction of a C-5(6) double bond into lathosterol and cholestanol

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• endoplasmic reticulum (IEA) | GO:0005783

Molecular Function

• C-5 sterol desaturase activity (IDA) | GO:0000248
• iron ion binding (IEA) | GO:0005506
• oxidoreductase activity (IEA) | GO:0016491

Biological Process

• fatty acid biosynthetic process (IEA) | GO:0006633
• obsolete oxidation-reduction process (IEA) | GO:0055114

Domains

No Data fetched for Domains

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_21011.1	9.997093137033517e-262
	Description: sterol desaturase (335 aa)
Tetrahymena borealis	EI9_01891.1	9.997093137033517e-262
	Description: protein kinase domain-containing protein (470 aa)
Stentor Coeruleus	SteCoe_10647	2.2856936767186716e-49
	Description: None
SGD	YLR056W	5.9971655715910366e-21
	Description: ERG3 C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources
Oxytricha	Contig18492.0.g71	0.000000030002053728821195
	Description: Fatty acid hydroxylase superfamily
DictyBase	DDB_G0279611	0.00010003404299092957
	Description: DDB_G0279611 on chromosome: 3 position 2316340 to 2317367

General Information

No Data fetched for General Information

Associated Literature

1. Ref:19525418: Nusblat AD, Najle SR, Tomazic ML, Uttaro AD, Nudel CB (2009) C-5(6) sterol desaturase from tetrahymena thermophila: Gene identification and knockout, sequence analysis, and comparison to other C-5(6) sterol desaturases. Eukaryotic cell 8(8):1287-97

Sequences

>TTHERM_01194720(coding)
ATGTTACAATTATAATTTTAAAATTCTTATTTAATTTATTGTTTGTTTTTGGGAAAGTAT
AATAAATAATTTACTATATTAATCGTGCTAAATGGATTAAAGATACATACATAAATAAAT
ATCAATCTTTAATAAAAATAAATAACAATAGCTTAAAGGCTAAATCAAGTTGAATAAATT
CAAGAAAAAAAATAAATTAAGTCCTCAATGGTTTATTGGCTTATTGCTGAATAGTTAGGT
TATTTTAATGTAGATAGAGTTAAGGTGATGCAAGATGCCAAGGATCACATTAGCTCTTCA
CTCAGATTGATTTAATTAGATAAATTATTCCCTACTTTCTCAAATTTTATTCTAGATTCT
GCTGGTTAATAAATTGGTAACATAATTATAGAATATATTTGCACTCTGATTCATACTATA
GTTTTCGCTTACATCCTCTACTTCACTGCAGCTACATCCTCCTACTTTTATTTCTTTGTG
TACAAGAAAAAGAAATATTTGCCTGAATTTAAAGGAGATTTAAAAATTGCATTTGATATC
AAATGGTCTTGTATTAACATTTTTGTTGAATCATTTTTAGTATCTGCATTAAGATTAGCT
ATGCCCAGATTCTCTATGATCTACTATGATATCAATGATCATAGTTGGCTCTACATCCCT
TTTAGCATTTTATTTCATATGATGTTTGATGAAACCCTAACTTACTGGGTTCATAGATGG
CTCCACACCTTCCCTTATTTATATACCAAATTGCATGTAGTTCATCATAGATCAAAAGAT
GTTACACCCTTCTCTGGCTTTGCTTTCCACCCACTTGATGCTTTTGCCTAAGCTGTCCCC
ACTTTTGTAAGCTGTTATTTCTTCCCTCTCCATATTAACATCTTGCTTGGATTCTCATTA
ATTACCACAATCTGGGCCATTTCTATTCACGATAATGTTCCTCTAGTGCCTTGCAAGCTC
TTTTTGTACAGTACCCACCATTCTATCCACCACGAAGCTGGAAGAGGTTAAATGACTAAC
TATGGTAAATTTACTTCTGTATGGGACAGAATATGTTAAACTTACTGGGATCCTGACAGG
GTTTATTTTGGATGGGATGAATGGAAATAAAGAAAAGGAATATTCAGTAAATTCAATAGC
TTTTATAGCAAAATAGTACCTGATAAAAGCTCAGAAGAACTAAACAAATAAATTAAACAA
AAAAAGAATTGA

>TTHERM_01194720(gene)
ATGTTACAATTATAATTTTAAAATTCTTATTTAATTTATTGTTTGTTTTTGGGAAAGTAT
AATAAATAATTTACTATATTAATCGTGCTAAATGGATTAAAGATACATACATAAATAAAT
ATCAATCTTTAATAAAAATAAATAACAATAGCTTAAAGGCTAAATCAAGTTGAATAAATT
CAAGAAAAGTAAAACAAGATTTATATATAATATTATTATTTAAAATAGAACTATCATAAA
ATATTATTAGAAAATAAATTAAGTCCTCAATGGTTTATTGGCTTATTGCTGAATAGTTAG
GTTATTTTAATGTAGATAGAGTTAAGGTGATGCAAGATGCCAAGGATCACATTAGCTCTT
CACTCAGATTGATTTAATTAGATAAATTATTCCCTACTTTCTCAAATTTTATTCTAGATT
CTGCTGGTTAATAAATTGGTAACATAATTATAGAATATATTTGCACTCTGATTCATACTA
TAGTTTTCGCTTACATCCTCTACTTCACTGCAGCTACATCCTCCTACTTTTATTTCTTTG
TGTAAATTTTTTTAAAAAGTAATTAAGCAAATAAGAGTTAAAAACTTCATAAATAGGTAC
AAGAAAAAGAAATATTTGCCTGAATTTAAAGGAGATTTAAAAATTGCATTTGATATCAAA
TGGTCTTGTATTAACATTTTTGTTGAATCATTTTTAGTATCTGCATTAAGATTAGCTATG
CCCAGATTCTCTATGATCTACTATGATATCAATGATCATAGTTGGCTCTACATCCCTTTT
AGCATTTTATTTCATATGATGTTTGATGAAACCCTAACTTACTGGGTTCATAGATGGCTC
CACACCTTCCCTTATTTATATACCAAAGTATTTTCTTTTAACTCTTAATCATTTTAACAA
ACTGATTAGCTTTTTTAAAGCATTAACAAGATAACTACTTTATAGAATTAGATTTAATTA
GATATTTTATTACCAATAGAAATTAAATAGATCTAACTATCTATCAATTGATATCTCAAT
ATTTAATTATTTTTTTGCAAATCTGATGAATTCAAATTTTAATAATATAATTAAATGTTT
TTTTAATTAATTACAAATATCTTTTGTATTAATTTCATAATTTATAATTAGTTGCATGTA
GTTCATCATAGATCAAAAGATGTTACACCCTTCTCTGGCTTTGCTTTCCACCCACTTGAT
GCTTTTGCCTAAGCTGTCCCCACTTTTGTAAGCTGTTATTTCTTCCCTCTCCATATTAAC
ATCTTGCTTGGATTCTCATTAATTACCACAATCTGGGCCATTTCTATTCACGATAATGTT
CCTCTAGTGCCTTGCAAGCTCTTTTTGTACAGTACCCACCATTCTATCCACCACGAAGCT
GGAAGAGGTTAAATGACTAACTATGGTAAATTTACTTCTGTATGGGACAGAATATGTTAA
ACTTACTGGGATCCTGACAGGGTTTATTTTGGATGGGATGAATGGAAATAAAGAAAAGGA
ATATTCAGTAAATTCAATAGCTTTTATAGCAAAATAGTACCTGATAAAAGCTCAGAAGAA
CTAAACAAATAAATTAAACAAAAAAAGAATTGA

>TTHERM_01194720(protein)
MLQLQFQNSYLIYCLFLGKYNKQFTILIVLNGLKIHTQININLQQKQITIAQRLNQVEQI
QEKKQIKSSMVYWLIAEQLGYFNVDRVKVMQDAKDHISSSLRLIQLDKLFPTFSNFILDS
AGQQIGNIIIEYICTLIHTIVFAYILYFTAATSSYFYFFVYKKKKYLPEFKGDLKIAFDI
KWSCINIFVESFLVSALRLAMPRFSMIYYDINDHSWLYIPFSILFHMMFDETLTYWVHRW
LHTFPYLYTKLHVVHHRSKDVTPFSGFAFHPLDAFAQAVPTFVSCYFFPLHINILLGFSL
ITTIWAISIHDNVPLVPCKLFLYSTHHSIHHEAGRGQMTNYGKFTSVWDRICQTYWDPDR
VYFGWDEWKQRKGIFSKFNSFYSKIVPDKSSEELNKQIKQKKN