Identifiers and Description

Gene Model Identifier

TTHERM_01243450

Standard Name

OGL1 (OGG1-Like)

Aliases

PreTt01756 | 287.m00027

Description

OGL1 HhH-GPD family base excision DNA repair protein; HhH-GPD superfamily base excision DNA repair protein

Genome Browser (Macronucleus)

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Genome Browser (Micronucleus)

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External Links

Gene Ontology Annotations

Molecular Function

Biological Process

Domains

  • ( PF00633 ) Helix-hairpin-helix motif
  • ( PF00730 ) base excision DNA repair protein,
  • ( PF07934 ) 8-oxoguanine DNA glycosylase, N-terminal domain
  • ( TIGR00161 ) conserved hypothetical protein TIGR00161
  • ( TIGR00588 ) 8-oxoguanine DNA-glycosylase (ogg)

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source Identifier Score
Tetrahymena borealis EI9_10178.1 9.997093137033517e-262
Description: HhH-GPD superfamily base excision DNA repair protein (378 aa)
Oxytricha Contig9033.0.g113 1.0004671766404936e-76
Description: 8-oxoguanine DNA glycosylase, N-terminal domain
DictyBase DDB_G0292618 5.001636743996964e-56
Description: ogg1 on chromosome: 6 position 1847428 to 1848747
SGD YML060W 1.000159011384939e-43
Description: OGG1 Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance

General Information

No. Gene Name(s) Paragraph Text
88 OGL1 Tetrahymena thermophila’s OGL1 protein is homologous to proteins from the HhH-GPD and OGG-N superfamilies, which are associated with DNA repair. It contains two domains; the first domain (E-value= 3.0 -17), in the HhH-GPD family, is a Helix-hairpin-helix and Gly/Pro rich loop, found on proteins that remove base lesions. The second domain (E-value=6.9-13), is common to oxoguanine gylcosylases, also known as OGG1, which removes 8-oxoG lesions. The closest homologs are in Scheffersomyces stipitis, a negative Crabtree yeast, and in Taphrina deformans, a fungi/plant pathogen, with 46% identical residues. OGL1 may be an essential protein in preventing mutations in DNA that lead to a short lifespan, early aging, and cancer. Paragraph by: Lillian Horin, Maite Cortes Garcia, Francis Ryu, Forrest Fulgenzi, Keck Science Center, Pitzer College

Associated Literature

No Data fetched for Associated Literature

Sequences 

>TTHERM_01243450(coding)
ATGAAGTCTCTAATAAACCCCTTAACTAAAAAGCCAATAACATAGATAGAATTCAATTTA
AAGAATACCTTGGTCAACGGCCAAGCATTTAATTGGATAAACAAAGATGTAACTTATAAC
AAAGAGTTTAGAGGGATTCTAGGTAAAAATGTAGTAGATTTTAAAGTTAATGAAAATAAT
GAAGTAATGTACAAAGAAATACCAGAAAATTCAAAAATTGAGGAGATTATTAATGATTAC
TTGCAATTAAATGTAGATTTAGTCAAGCTTACTGTTGAGTGGTCAGAAAAAGATAACTAT
TATGCTAAAGTCAAAGAATAGTTAAAAGGAGTTCGTATCTTGAGATAGTTTCCATTTGAG
TGCATGATTAGCTTTATATGTTCCTAAAACAATAATATTCCAAGAATTACTAAAATTTTA
AAAAGTTTGAGATAGAATTTTGGAGAGGAAATTTATAGAGAAAAATTAGAAGATGGTAGC
GAAGAAATTTATTATAGTTTTCCATCTGTAGCATCATTGAGGAAAGCAACAGAACAAAAT
CTCAGAGATTTGGGATTGGGTTATAGAGCTAATTATATTGTCTCAGCAGTTTAGCTACTT
GAGGAGAAAGGAGGAGAAGAATATTTGCACAAATTGCGCTAGCTGAAAGATTCACATGAG
AAAAGAGAAGCCCTGCTTGAATTCAAAGGAATAGGAAATAAAGTAGCAGATTGTATATCT
CTCTTTAGCTTAGATGCAAAAGATTTAATCCCTGTAGATACTCATGTTTTTCAAATATAT
AATAGAGTTTACAAAAAAAATAAAAACAAAGATAAAAAAATGACAAAAGATCAGTATTCA
GAAATAGAAAATTTCTTTAAAGATCTATATGGAGATTATGCAGGATGGGCCCATCAAGCT
ATTTTTGCGGCTGAACTCGTCTCTTTTTAGTCAGAAATTAACTCAAACGAAAACTCTTCA
GTAAAAAAAACAAAATCATCAAAATTACAAGAGGAAAAAGAATAAGAAAAAGAATAAACT
ACAGAGGAGTAAAAAATTATTTCTAAAAGTAAAATTAGCGAATAAACATCTTCAGAGAAA
AATAAAAGAAATTAAAACAAAAAAATAAAGTGA


>TTHERM_01243450(gene)
ATGAAGTCTCTAATAAACCCCTTAACTAAAAAGCCAATAACATAGATAGAATTCAATTTA
AAGAATACCTTGGTCAACGGCCAAGCATTTAATTGGATAAACAAAGATGTAACTTATAAC
AAAGAGTTTAGAGGGATTCTAGGTAAAAATGTAGTAGATTTTAAAGTAAAATTAAATGAA
AATTATTTTCATAATAAACATAATTAAAATCAAAAATTTAATGAAAGGTTAATGAAAATA
ATGAAGTAATGTACAAAGAAATACCAGAAAATTCAAAAATTGAGGAGATTATTAATGATT
ACTTGCAATTAAATGTAGATTTAGTCAAGCTTACTGTTGAGTGGTCAGAAAAAGATAACT
ATTATGCTAAAGTCAAAGAATAGTTAAAAGGAGTTCGTATCTTGAGATAGTTTCCATTTG
AGTGCATGATTAGCTTTATATGTTCCTAAAACAATAATATTCCAAGAATTACTAAAATTT
TAAAAAGTTTGAGATAGAATTTTGGAGAGGAAATTTATAGAGAAAAATTAGAAGATGGTA
GCGAAGAAATTTATTATAGTTTTCCATCTGTAGCATCATTGAGGAAAGCAACAGAACAAA
ATCTCAGAGATTTGGGATTGGGTTATAGAGCTAATTATATTGTCTCAGCAGTTTAGCTAC
TTGAGGAGAAAGGAGGAGAAGAATATTTGCACAAATTGCGCTAGCTGAAAGATTCACATG
AGAAAAGAGAAGCCCTGCTTGAATTCAAAGGAATAGGAAATAAAGTAGCAGATTGTATAT
CTCTCTTTAGCTTAGATGCAAAAGATTTAATCCCTGTAGATACTCATGTTTTTCAAATAT
ATAATAGAGTTTACAAAAAAAATAAAAACAAAGATAAAAAAATGACAAAAGATCAGTATT
CAGAAATAGAAAATTTCTTTAAAGATCTATATGGAGATTATGCAGGATGGGCCCATCAAG
CTATTTTTGCGGCTGAACTCGTCTCTTTTTAGTCAGAAATTAACTCAAACGAAAACTCTT
CAGTAAAAAAAACAAAATCATCAAAATTACAAGAGGAAAAAGAATAAGAAAAAGAATAAA
CTACAGAGGAGTAAAAAATTATTTCTAAAAGTAAAATTAGCGAATAAACATCTTCAGAGA
AAAATAAAAGAAATTAAAACAAAAAAATAAAGTGA


>TTHERM_01243450(protein)
MKSLINPLTKKPITQIEFNLKNTLVNGQAFNWINKDVTYNKEFRGILGKNVVDFKVNENN
EVMYKEIPENSKIEEIINDYLQLNVDLVKLTVEWSEKDNYYAKVKEQLKGVRILRQFPFE
CMISFICSQNNNIPRITKILKSLRQNFGEEIYREKLEDGSEEIYYSFPSVASLRKATEQN
LRDLGLGYRANYIVSAVQLLEEKGGEEYLHKLRQLKDSHEKREALLEFKGIGNKVADCIS
LFSLDAKDLIPVDTHVFQIYNRVYKKNKNKDKKMTKDQYSEIENFFKDLYGDYAGWAHQA
IFAAELVSFQSEINSNENSSVKKTKSSKLQEEKEQEKEQTTEEQKIISKSKISEQTSSEK
NKRNQNKKIK