Identifiers and Description

Gene Model Identifier

TTHERM_01299650

Standard Name

TOP1 (Topoisomerase I)

Aliases

PreTt17571 | 315.m00022

Description

TOP1 DNA topoisomerase I; Eukaryotic DNA topoisomerase I- catalytic core family protein

Genome Browser (Macronucleus)



Genome Browser (Micronucleus)

External Links

Gene Ontology Annotations

Cellular Component

Molecular Function

  • DNA binding (IEA) | GO:0003677
  • DNA topoisomerase type I (single strand cut, ATP-independent) activity (IEA) | GO:0003917
  • DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity (IEA) | GO:0003918

Biological Process

Domains

  • ( PF01028 ) Eukaryotic DNA topoisomerase I, catalytic
  • ( PF02919 ) Eukaryotic DNA topoisomerase I, DNA

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source Identifier Score
Stentor Coeruleus SteCoe_24070 0
Description: None
Tetrahymena borealis EI9_19658.1 9.997093137033517e-262
Description: eukaryotic DNA topoisomerase I, catalytic core family protein (691 aa)
Oxytricha Contig11896.0.g103 9.997093137033517e-262
Description: Eukaryotic DNA topoisomerase I, catalytic core
DictyBase DDB_G0283205 1.9990846765523993e-155
Description: top1 on chromosome: 4 position 416900 to 419809
SGD YOL006C 1.999872053281847e-142
Description: TOP1 Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination
WormBase WBGene00006595 1.0003279799459891e-139
Description: locus:top-1 DNA topoisomerase 1 status:Confirmed UniProt:O17966 protein_id:CAB07639.1

General Information

No Data fetched for General Information

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_01299650(coding)
ATGAGTAGCAAGAAGAACACTAAGAAAGTCTCTGATAGCGAGGACGATGATTTTGAAGAG
GAAGAAGATGAATCAGAAGGTTCAGGAGAGGAGGATTCCGCTGAAAATAGTGTCAAAGAA
GAAGAAGATGAAGAAGAAGAAGAAAACGGTGATAATGAAATTAAAGAGGAAGATAACGCA
GATACAAAAATAGAAGTTAAGGATGAAAATGAAGATGATGAAGAAGAAGAAGAATTTAAA
CCTTCGATTAATGGCAATAAAAGAAAGAACGATACACCTGTTGAAAAGGCAGCAGGATTG
TCAAATGCTAAATAAGTGAAAACATCTGGCGGTGATGCAGTTAAGAAACCAGTGTAAAAG
TAACAAGACAGTGATGATGAAGACGATGAAAACAGTGATATTAAATGGAAATATTTAGAG
CATCACGGAGTGCTATTCCCCGATTATTGGTAAAAGCATAATGTAAGACCTAGGTATGAT
GGAAAACCTATTGATTTAAATCTCTTGTAAGAAGAAATGGCTACTTATTGGTCATAAACT
TTAGGAACAGATTGGGAACATAAACCTAAGTACAGAGAGAATTTTTCAAAACAATTCCTC
GATACCTTTGGTAAGGATAAAGGTAAATATGACTTTGATAAGTTCGACTTCACTCCTATA
AAAATACATCTTGAAGAGCAAAAAGAAATCCGTAAAAATCGCTCCAAAGAAGAAAAAAAT
CAAGAAAAGTAGAAAAAAGAAAGGCTTTCTGATTATTATGCTGGCGCAATTCTAGACGGA
TTTAGAGAAAAAGTAGGATAATTCATGATTGAACCTCCAACTCTCTTTAAAGGTAGAGGT
GAACATCCAAAAATGGGTATGATGAAAGGTCGTATTTAACCAGAAGCTGTTGTTATTAAT
ATCTCAAAAGATGCACCTGTCCCAAAATGTTCAGTTCCTGGTCATGGTTGGAGTGAAATA
GTCCACAAACAAGATGTTACTTGGTTAGCAAGCTACAAGGATGATTCTGTAAAGAAGCAA
CATAAATATATCTTCTTATCTGCTGAAAGTAAGCTTAAGGCAGAAAATGATAAAAAGAAA
TACGAAAAAGCAAGACGTCTTAAAAATTTAATTGGATAGATTCGTGAAAATTACGAGAGA
AAATTAAGAAGTAGTGATCCTGTTGATAGATAATTAGGTACTGCTACTTACTTGATTGAT
AAGTTAGCACTCAGAGTTGGTAATGAAAAATCAGAAGAAGAAGCAGATACTGTCGGTTGC
TGCTCTTTGAGAGTTGAGCATATTTAAGTTATAGAAGATACCTAGATTGGATTCGATTTC
TTAGGTAAGGATTCTATGAGATATCAAAATACTGTAAAAGTTACTGAGATTGTTTGGAAA
AATATGTAGTCTTTTATCAAGAATAAAAAACCTGGTGATGATTTATTCGATAGAATTGAT
GCAAGTAGCCTAAATGAATATTTAAAGAGTTAGATGGAAGGTTTGACAGCAAAAGTTTTT
AGAACTTATAATGCTTCTCACACTCTTTAAAAAGAATTAGACAAGGCTGATGAAGAAGGC
CTTGATAAGATGGATTTAAAAGATAAACTTAATTTTTATGATGAAGCTAACAGAAATGTT
GCCATTCTTTGTAACCATCAAAAAACAGTAGGCAAAAACTTTGATGTAATGGTTGGAAAA
ATGGAACAAAGAATTAATGTTTATAAAGATTATGAAAAGGAATTACATACTCATTTAAAC
AAATGCAAAAAGAATGGAGTCAATGCTTATGAAAAAGAAGTTATCTTAGAAGAAAAGGAT
GATGGAAAACATAAAATGTTTGTTAAAAAGTTCCCTGGAACAAAGGAAAAAATTTAAGAA
GCTATTGAAAAAATTAAAAAGAAGATAGACGAAGAATAAAATAAAAAATAATCTAAAGAG
AAGAACAAAGAAATTGCCTTAGGTACTTCTAAAACAAATTACAACGATCCTAGAATATCT
GTTGTTTGGTGTAAAAAGTGGGAAGTTCCTGTAGAAAAAGTTTTCCCTAAAACTCTCATT
GCTAAGTTCGTTTGGGCTATGGATACAGATTTAGAGTGGTCATTCTGA


>TTHERM_01299650(gene)
ATGAGTAGCAAGAAGAACACTAAGAAAGTCTCTGATAGCGAGGACGATGATTTTGAAGAG
GAAGAAGATGAATCAGAAGGTTCAGGAGAGGAGGATTCCGCTGAAAATAGTGTCAAAGAA
GAAGAAGATGAAGAAGAAGAAGAAAACGGTGATAATGAAATTAAAGAGGAAGATAACGCA
GATACAAAAATAGAAGTTAAGGATGAAAATGAAGATGATGAAGAAGAAGAAGAATTTAAA
CCTTCGATTAATGGCAATAAAAGAAAGAACGATACACCTGTTGAAAAGGCAGCAGGATTG
TCAAATGCTAAATAAGTGAAAACATCTGGCGGTGATGCAGTTAAGAAACCAGTGTAAAAG
TAACAAGACAGTGATGATGAAGACGATGAAAACAGTGATATTAAATGGAAATATTTAGAG
CATCACGGAGTGCTATTCCCCGATTATTGGTAAAAGCATAATGTAAGACCTAGGTATGAT
GGAAAACCTATTGATTTAAATCTCTTGTAAGAAGAAATGGCTACTTATTGGTCATAAACT
TTAGGAACAGATTGGGAACATAAACCTAAGTACAGAGAGAATTTTTCAAAACAATTCCTC
GATACCTTTGGTAAGGATAAAGGTAAATATGACTTTGATAAGTTCGACTTCACTCCTATA
AAAATACATCTTGAAGAGCAAAAAGAAATCCGTAAAAATCGCTCCAAAGAAGAAAAAAAT
CAAGAAAAGTAGAAAAAAGAAAGGCTTTCTGATTATTATGCTGGCGCAATTCTAGACGGA
TTTAGAGAAAAAGTAGGATAATTCATGATTGAACCTCCAACTCTCTTTAAAGGTAGAGGT
GAACATCCAAAAATGGGTATGATGAAAGGTCGTATTTAACCAGAAGCTGTTGTTATTAAT
ATCTCAAAAGATGCACCTGTCCCAAAATGTTCAGTTCCTGGTAAAATAAATTAATTTATT
TATTATAATTATCTATGATAAATAAAAAATTTTAAGTATCCTACTAAAAGTTATAAACAA
ACAACAAGCATTCATTCATTCATTCATTCATTTTCTGGCCAATTAAATTTTAATATCTTT
AAACTTAATATTCTCTCTTTTCATAATATAATTATGTTTATAATGCCAATATTAAATCAA
TTTGTTTCATATTTAATGTATTTTCAAAAGCTATACATCCTTAATTAATCATATTTAGCT
TTTTACACAAGACTGTATTCATATATGTAGATAGATATTTAACGAATTTCCTAAAAAATA
ATTAGGTCATGGTTGGAGTGAAATAGTCCACAAACAAGATGTTACTTGGTTAGCAAGCTA
CAAGGATGATTCTGTAAAGAAGCAACATAAATATATCTTCTTATCTGCTGAAAGTAAGCT
TAAGGCAGAAAATGATAAAAAGAAATACGAAAAAGCAAGACGTCTTAAAAATTTAATTGG
ATAGATTCGTGAAAATTACGAGAGAAAATTAAGAAGTAGTGATCCTGTTGATAGATAATT
AGGTACTGCTACTTACTTGATTGATAAGTTAGCACTCAGAGTTGGTAATGAAAAATCAGA
AGAAGAAGCAGATACTGTCGGTTGCTGCTCTTTGAGAGTTGAGCATATTTAAGTTATAGA
AGATACCTAGATTGGATTCGATTTCTTAGGTATTTAAATTTTTTTCTATTATTAAAATAA
TCAATTTATTTTTATTTATTTATGTAGACAAAATTTTATATAAAATTAATTTTTAAAAAA
GGTAAGGATTCTATGAGATATCAAAATACTGTAAAAGTTACTGAGATTGTTTGGAAAAAT
ATGTAGTCTTTTATCAAGAATAAAAAACCTGGTGATGATTTATTCGATAGAATTGATGCA
AGTAGCCTAAATGAATATTTAAAGAGTTAGATGGAAGGTTTGACAGCAAAAGTTTTTAGA
ACTTATAATGCTTCTCACACTCTTTAAAAAGAATTAGACAAGGCTGATGAAGAAGGCCTT
GATAAGATGGATTTAAAAGATAAACTTAATTTTTATGATGAAGCTAACAGAAATGTTGCC
ATTCTTTGTAACCATCAAAAAACAGTAGGCAAAAACTTTGATGTAATGGTTGGAAAAATG
GAACAAAGAATTAATGTTTATAAAGATTATGAAAAGGAATTACATACTCATTTAAACAAA
TGCAAAAAGAATGGAGTCAATGCTTATGAAAAAGAAGTTATCTTAGAAGAAAAGGATGAT
GGAAAACATAAAATGTTTGTTAAAAAGTTCCCTGGAACAAAGGAAAAAATTTAAGAAGCT
ATTGAAAAAATTAAAAAGAAGATAGACGAAGAATAAAATAAAAAATAATCTAAAGAGAAG
AACAAAGAAATTGCCTTAGGTACTTCTAAAACAAATTACAACGATCCTAGAATATCTGTT
GTTTGGTGTAAAAAGTGGGAAGTTCCTGTAGAAAAAGTTTTCCCTAAAACTCTCATTGCT
AAGTTCGTTTGGGCTATGGATACAGATTTAGAGTGGTCATTCTGA


>TTHERM_01299650(protein)
MSSKKNTKKVSDSEDDDFEEEEDESEGSGEEDSAENSVKEEEDEEEEENGDNEIKEEDNA
DTKIEVKDENEDDEEEEEFKPSINGNKRKNDTPVEKAAGLSNAKQVKTSGGDAVKKPVQK
QQDSDDEDDENSDIKWKYLEHHGVLFPDYWQKHNVRPRYDGKPIDLNLLQEEMATYWSQT
LGTDWEHKPKYRENFSKQFLDTFGKDKGKYDFDKFDFTPIKIHLEEQKEIRKNRSKEEKN
QEKQKKERLSDYYAGAILDGFREKVGQFMIEPPTLFKGRGEHPKMGMMKGRIQPEAVVIN
ISKDAPVPKCSVPGHGWSEIVHKQDVTWLASYKDDSVKKQHKYIFLSAESKLKAENDKKK
YEKARRLKNLIGQIRENYERKLRSSDPVDRQLGTATYLIDKLALRVGNEKSEEEADTVGC
CSLRVEHIQVIEDTQIGFDFLGKDSMRYQNTVKVTEIVWKNMQSFIKNKKPGDDLFDRID
ASSLNEYLKSQMEGLTAKVFRTYNASHTLQKELDKADEEGLDKMDLKDKLNFYDEANRNV
AILCNHQKTVGKNFDVMVGKMEQRINVYKDYEKELHTHLNKCKKNGVNAYEKEVILEEKD
DGKHKMFVKKFPGTKEKIQEAIEKIKKKIDEEQNKKQSKEKNKEIALGTSKTNYNDPRIS
VVWCKKWEVPVEKVFPKTLIAKFVWAMDTDLEWSF