Identifiers and Description

Gene Model Identifier

TTHERM_00185640

Standard Name

JMJ1 (JMJC domain-encoding 1)

Aliases

PreTt29886 | 14.m00453

Description

JMJ1 JmjC domain protein; JmjC domain containing protein; Transcriptional Corepressor and Histone Demethylase

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Biological Process

• obsolete histone H3-K27 demethylation (IMP) | GO:0071557

Domains

• ( PF02373 ) JmjC domain, hydroxylase

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

No Data fetched for Homologs

General Information

No.	Gene Name(s)	Paragraph Text
2321	COI7, COI6, JMJ1, LIA5	Coi6p, its interaction partners Coi7p and Lia5p, and the histone demethylase Jmj1p are crucial for confining the production of small RNAs and the formation of heterochromatin to the eliminated sequences. The loss of Coi6p, Coi7p or Jmj1p causes ectopic DNA elimination.

Associated Literature

1. Ref:29021213: Noto T, Mochizuki K (2017) Whats, hows and whys of programmed DNA elimination in Tetrahymena. Open biology 7(10):
2. Ref:28273462: Suhren JH, Noto T, Kataoka K, Gao S, Liu Y, Mochizuki K (2017) Negative Regulators of an RNAi-Heterochromatin Positive Feedback Loop Safeguard Somatic Genome Integrity in Tetrahymena. Cell reports 18(10):2494-2507
3. Ref:26688337: Kataoka K, Mochizuki K (2015) Phosphorylation of an HP1-like Protein Regulates Heterochromatin Body Assembly for DNA Elimination. Developmental cell 35(6):775-88
4. Ref:22427430: Chung PH, Yao MC (2012) Tetrahymena thermophila JMJD3 homolog regulates H3K27 methylation and nuclear differentiation. Eukaryotic cell 11(5):601-14

Sequences

>TTHERM_00185640(coding)
ATGAATCTTAGGAACAAGAGAAAGGTTTCTTCAAGTACTAGCGAAGAAAAAGACTAACAC
TTTAGTTCTAGCCTGATTTAAACTAATGAAAATATAAATTCGAATGCAACAACTTCGGTC
AATATCGATTCTACTGCAGCATACAATATTTCTTAGGAAAAAGAAGGTTCTCCTAAAAAG
AATGGATTGGCAGCTAACTCCAGCAGCACTTTCGTCTCCACAACTGACTAAATCCTAATA
AATGGAAACAACGTATCAAAGAAAATCAAGACAAATAGCGGTGCTGCATTTCAAACTTAA
GTTTCTGCGAATGCTCCTTGCTTAAAATCAGCAGAACAAATTATTTAGCATTAGTAGAAT
GTTAATAATGATTGTGATATTGACTGCGATGGATTTCGCGAAATATTTCCTGAAGACCTA
CACACATAGTTGTAGGAAGCAATTTATAAAGAATAAACCATCGTTTTGAGAGAAGCAGCT
GGCCCTAAAGGTTTTAATGTGAACCCCAAAAACTTATTTAGCTTTGAAAGTGTGATTAAA
AATCATAGCGATATGTAAATTGACTGTAGAGTTTAAAATCCTACAGTTTATGGCTTTAAT
GTTTTAAATCCCAAAAACCAATAGCATGTCTACAATACCACCATTTAGGAATACGGAGAG
TATGCTGCATTGCTTTAAGAAGACAGGTACGAAGAAATTAAGAAAAAACCATATTACAAA
GAATACTTTAGCAAACTATCTAACGGAGTAATGTTTGCTGTAAACATTGACATGGATGAT
TTTAATTGGTAAACCGAAAACATGCGTCTGAGATCAGGGCTTCCCCATTACCTCCTAAAT
AAAGGCAAACATGATATCCTTAGCTACCATAGGTAAAACGTTATGGGATGCACTCAACCT
TAAATGTACCTAAAAGTCGCTGGAGTGTGGACTGGAGGACACCAAGAGAACATCTCTGTC
AGAGCTATAAATATCAACCACGGAGATGGTGACAGTGATTGGTATTGCGTCGATTTTGAC
TAAGTAGAAAAGTATAGAAATTATGTGAAAAGAAAATATTAAGTTGATATACATGGCGAT
GAAGGTCTATGGTTCGGAAAGTATAATGACCCAGATGTTATCAAAGCAGGGATCAGGATA
AAAAAAGTTATTTAAAGAAAAAATGATATTGTCATTTTAGCTCCTGGAGTTTTGCATTGG
GTACGCTGCAGAGGTAGAAGTGTGTAAACTGCATGGAATTTTGCTTACAGAAGGATTGAA
GACATAATTGCTATGAATGAAAGATTTTTGTATAATTAAAAAATCAACTTTGAAACAATA
ATATTGAATAAATCTCTTTTTATGGATTTACTTAATTTTGAGTACCACAATTTACCTTTG
GAAGTAGCACAGAAATTGCATAGTATTGTCGCTGATTACTATTAGAAAGAATACTAATTT
GAACAAAATTTGACTCACTATCCATTTAAATGTAAGAACTAAGTGATTTTTTATGACTAA
ATGCCTGCTTAGCTTAAACACATCCAAATTTATTACTGCAGCTAAATAGGCTGTGGAAAA
GAAATATTTTGCTATTTCGGTATCCTCCGCTCTGAATTCTAATATCAAGAACCTAACAAT
AGCCTATTCCTTTCTTAAGATTTTTGTGGAAAGTATTTCTGTCCTCTTTGCATTTAGGAA
ATGAAAAAAATTGATGATTCTATAATACTTTTTAGAAAATTTGATCTAAATTCGTTGAAG
ACTTTGTTGAACAGAGTTTATAATTATATTTAGGAAGAAGGAAAGTAATAGTCTCTCTAC
CCTATTTCCGATTTAACCAACATTAGTCACTTCTGTGGTTAAATCGCTAACATAAATGAC
TTTGTTTTTAACAAAGACGTAAGGAGATTAGAGCAAGTTTACATTCCTGATGTCTTCGCC
TCATAGGGAGTCGAAGAAATGTAGAAATTTCAACTAGATTTGTAATCAGGAAGACTTATC
GATTTTATTGAGAAACCTATTATGAAATTTATTGCACCTAACTAGCAGTAGAGATGTCAA
GATATTATGCATGATGGTGAGGATGATTAGGAGAAAGATAGTCAATAAGTTAAGATAGAA
GATGCTGGTAAAAAAGAAGATGATAGTTTGGTTTCTAATAGTCAATAAGTTAAATCAGCT
AATAAGAATAAAGTTCAGTAGTAGCAACAATAATAAATTGCTACTCAATTAACAAACTAA
GAATTAAAAGAAAATTTGAAAAATGGATAGATATAGCAGAAGTAGTTATCTTTGAATTTT
GAATCAGTAGAAAATAACGATTTAAGCCAAAACAAAAATACAAATCAACATGACGATGAA
AAATATGCAATATAGTTGCAATAAGAATTGGACTACATGGGTTCTAAGACTCGCAAATAA
AAAAACAATTCTCAGCTCCTCATTTCTCATGATTATGAAATATCTTCACTCACTCAATCT
TCGAGAGTTCTAAGAGGAGGGAGATCTCTTTGTTCTAAACCTCCCTCACAAAACTAAAGA
AAAAAAGCTCAGTAAAACAAAATCACAAGCTTGAAATCTATATCTGAGTCTAATGACAGC
TCAAAATAAAGCTCCAAACAGAACCCAAATGAGGCTTAATCACCCACTTCATCATCTACT
ACAATTGGTGTTTCAACAAATTTAGCTAGTCCCTCACTTTAAGCTCAATAAAATATCAAG
ACTAAAATAGAACAAACTAATGTATTACCTTCAGATTCTTAAATGGTGATAGAAGAATAA
CCCTCAACACCATAACAATAAATAGATGATGAAAGTAGCTTTTAATTTTCTTAAAAAATT
AATTATAAAATAGTAAGCAGGAGTAACAGCAATTCGTGCAAAAAAAGCTAATTGAACACA
CAGACTACTAGCTAGTAAAATAAAACTATTGATGAAAACAAAAAAATTAAAATCAAAGGC
TATATTTCAGATGACGATGATGCTAATGACCAAGAAGAAATAGAAAAACAAAGAATAAGA
AAAGAGCGCGAATAGCAAAGAGTAAAAATGTTGGAATAGTTGGAAAAAAGTTAAAAAGAG
AAAGAATCTGAGACTAAATAAATCACTAAAGAAACTAAATAATAAAAAACTCCTTCAAGT
GACTATGAAGATAATCCAAATATTTATAAAAGAAGATTAAACTTAAAATAAATTACTAAT
AGCTCAAACTGA

>TTHERM_00185640(gene)
GTGAAAAAGAGTTAGCAATAAATTAAATTGAAGTGAAAATCAGCTAGGATTTCTAATTAT
TAGAATGATTTAAATAAACAAAATTTTTTTTTGCACAATTTAAGAATGAAATTAGTTAAA
CACTTTTGATACATAGAATTGATCCAAATTATCTTATGAATCTTAGGAACAAGAGAAAGG
TTTCTTCAAGTACTAGCGAAGAAAAAGACTAACACTTTAGTTCTAGCCTGATTTAAACTA
ATGAAAATATAAATTCGAATGCAACAACTTCGGTCAATATCGATTCTACTGCAGCATACA
ATATTTCTTAGGAAAAAGAAGGTTCTCCTAAAAAGAATGGATTGGCAGCTAACTCCAGCA
GCACTTTCGTCTCCACAACTGACTAAATCCTAATAAATGGAAACAACGTATCAAAGAAAA
TCAAGACAAATAGCGGTGCTGCATTTCAAACTTAAGTTTCTGCGAATGCTCCTTGCTTAA
AATCAGCAGAACAAATTATTTAGCATTAGTAGAATGTTAATAATGATTGTGATATTGACT
GCGATGGATTTCGCGAAATATTTCCTGAAGACCTACACACATAGTTGTAGGAAGCAATTT
ATAAAGAATAAACCATCGTTTTGAGAGAAGCAGCTGGCCCTAAAGGTTTTAATGTGAACC
CCAAAAACTTATTTAGCTTTGAAAGTGTGATTAAAAATCATAGCGATATGTAAATTGACT
GTAGAGTTTAAAATCCTACAGTTTATGGCTTTAATGTTTTAAATCCCAAAAACCAATAGC
ATGTCTACAATACCACCATTTAGGAATACGGAGAGTATGCTGCATTGCTTTAAGAAGACA
GGTACGAAGAAATTAAGAAAAAACCATATTACAAAGAATACTTTAGCAAACTATCTAACG
GAGTAATGTTTGCTGTAAACATTGACATGGATGATTTTAATTGGTAAACCGAAAACATGC
GTCTGAGATCAGGGCTTCCCCATTACCTCCTAAATAAAGGCAAACATGATATCCTTAGCT
ACCATAGGTAAAACGTTATGGGATGCACTCAACCTTAAATGTACCTAAAAGTCGCTGGAG
TGTGGACTGGAGGACACCAAGAGAACATCTCTGTCAGAGCTATAAATATCAACCACGGAG
ATGGTGACAGTGATTGGTATTGCGTCGATTTTGACTAAGTAGAAAAGTATAGAAATTATG
TGAAAAGAAAATATTAAGTTGATATACATGGCGATGAAGGTCTATGGTTCGGAAAGTATA
ATGACCCAGATGTTATCAAAGCAGGGATCAGGATAAAAAAAGTTATTTAAAGAAAAAATG
ATATTGTCATTTTAGCTCCTGGAGTTTTGCATTGGGTACGCTGCAGAGGTAGAAGTGTGT
AAACTGCATGGAATTTTGCTTACAGAAGGATTGAAGACATAATTGCTATGAATGAAAGAT
TTTTGTATAATTAAAAAATCAACTTTGAAACAATAATATTGAATAAATCTCTTTTTATGG
ATTTACTTAATTTTGAGTACCACAATTTACCTTTGGAAGTAGCACAGAAATTGCATAGTA
TTGTCGCTGATTACTATTAGAAAGAATACTAATTTGAACAAAATTTGACTCACTATCCAT
TTAAATGTAAGAACTAAGTGATTTTTTATGACTAAATGCCTGCTTAGCTTAAACACATCC
AAATTTATTACTGCAGCTAAATAGGCTGTGGAAAAGAAATATTTTGCTATTTCGGTATCC
TCCGCTCTGAATTCTAATATCAAGAACCTAACAATAGCCTATTCCTTTCTTAAGATTTTT
GTGGAAAGTATTTCTGTCCTCTTTGCATTTAGGAAATGAAAAAAATTGATGATTCTATAA
TACTTTTTAGAAAATTTGATCTAAATTCGTTGAAGACTTTGTTGAACAGAGTTTATAATT
ATATTTAGGAAGAAGGAAAGTAATAGTCTCTCTACCCTATTTCCGATTTAACCAACATTA
GTCACTTCTGTGGTTAAATCGCTAACATAAATGACTTTGTTTTTAACAAAGACGTAAGGA
GATTAGAGCAAGTTTACATTCCTGATGTCTTCGCCTCATAGGGAGTCGAAGAAATGTAGA
AATTTCAACTAGATTTGTAATCAGGAAGACTTATCGATTTTATTGAGAAACCTATTATGA
AATTTATTGCACCTAACTAGCAGTAGAGATGTCAAGATATTATGCATGATGGTGAGGATG
ATTAGGAGAAAGATAGTCAATAAGTTAAGATAGAAGATGCTGGTAAAAAAGAAGATGATA
GTTTGGTTTCTAATAGTCAATAAGTTAAATCAGCTAATAAGAATAAAGTTCAGTAGTAGC
AACAATAATAAATTGCTACTCAATTAACAAACTAAGAATTAAAAGAAAATTTGAAAAATG
GATAGATATAGCAGAAGTAGTTATCTTTGAATTTTGAATCAGTAGAAAATAACGATTTAA
GCCAAAACAAAAATACAAATCAACATGACGATGAAAAATATGCAATATAGTTGCAATAAG
AATTGGACTACATGGGTTCTAAGACTCGCAAATAAAAAAACAATTCTCAGCTCCTCATTT
CTCATGATTATGAAATATCTTCACTCACTCAATCTTCGAGAGTTCTAAGAGGAGGGAGAT
CTCTTTGTTCTAAACCTCCCTCACAAAACTAAAGAAAAAAAGCTCAGTAAAACAAAATCA
CAAGCTTGAAATCTATATCTGAGTCTAATGACAGCTCAAAATAAAGCTCCAAACAGAACC
CAAATGAGGCTTAATCACCCACTTCATCATCTACTACAATTGGTGTTTCAACAAATTTAG
CTAGTCCCTCACTTTAAGCTCAATAAAATATCAAGACTAAAATAGAACAAACTAATGTAT
TACCTTCAGATTCTTAAATGGTGATAGAAGAATAACCCTCAACACCATAACAATAAATAG
ATGATGAAAGTAGCTTTTAATTTTCTTAAAAAATTAATTATAAAATAGTAAGCAGGAGTA
ACAGCAATTCGTGCAAAAAAAGCTAATTGAACACACAGACTACTAGCTAGTAAAATAAAA
CTATTGATGAAAACAAAAAAATTAAAATCAAAGGCTATATTTCAGATGACGATGATGCTA
ATGACCAAGAAGAAATAGAAAAACAAAGAATAAGAAAAGAGCGCGAATAGCAAAGAGTAA
AAATGTTGGAATAGTTGGAAAAAAGTTAAAAAGAGAAAGAATCTGAGACTAAATAAATCA
CTAAAGAAACTAAATAATAAAAAACTCCTTCAAGTGACTATGAAGATAATCCAAATATTT
ATAAAAGAAGATTAAACTTAAAATAAATTACTAATAGCTCAAACTGATTTACAAGTTTAG
AATTAAATAGCTCTAATTAATTAGTAGGCAAAATAACTTAATTATTTACCTATTTACTTA
CTTTCTTACACGCATACACGCATACTTACTTACTTCCTAACTCAATGACTTCTTTTTTAA
TTAATAATTATAAGACTTTTTTATAAATAAAAACGAACTTTTTACTTCTAACAAACCAAC
AAATAAAAAAACAAACAAACTAACTAACCATTAGATAAATAAATAAATTAATTCCTACAA
AAATTTTTCTGTTAAAAAATAATATAAAAAAATATATTAAATTATTTCTTGAGCAGAATT
TTTGAGAGTTATTATGAATCAAACAAACAAACATACATACATATTCAACAAATAGAAAAA
GTATTAACCAAAATAAATAAAATATTTCAAACAAACCCAAAATTTTAGTTTTAGTTGATT
AATCAATGAATTTATTTATATATATATTATATATCCAGTTATCAATTATGTATCTTTATT
TTATTGTTATTATTATCACCATACATATTATCATCATCTTTTTATTTATAATTGAAAATT
AATGATCTTTAAATTTTTACGAA

>TTHERM_00185640(protein)
MNLRNKRKVSSSTSEEKDQHFSSSLIQTNENINSNATTSVNIDSTAAYNISQEKEGSPKK
NGLAANSSSTFVSTTDQILINGNNVSKKIKTNSGAAFQTQVSANAPCLKSAEQIIQHQQN
VNNDCDIDCDGFREIFPEDLHTQLQEAIYKEQTIVLREAAGPKGFNVNPKNLFSFESVIK
NHSDMQIDCRVQNPTVYGFNVLNPKNQQHVYNTTIQEYGEYAALLQEDRYEEIKKKPYYK
EYFSKLSNGVMFAVNIDMDDFNWQTENMRLRSGLPHYLLNKGKHDILSYHRQNVMGCTQP
QMYLKVAGVWTGGHQENISVRAININHGDGDSDWYCVDFDQVEKYRNYVKRKYQVDIHGD
EGLWFGKYNDPDVIKAGIRIKKVIQRKNDIVILAPGVLHWVRCRGRSVQTAWNFAYRRIE
DIIAMNERFLYNQKINFETIILNKSLFMDLLNFEYHNLPLEVAQKLHSIVADYYQKEYQF
EQNLTHYPFKCKNQVIFYDQMPAQLKHIQIYYCSQIGCGKEIFCYFGILRSEFQYQEPNN
SLFLSQDFCGKYFCPLCIQEMKKIDDSIILFRKFDLNSLKTLLNRVYNYIQEEGKQQSLY
PISDLTNISHFCGQIANINDFVFNKDVRRLEQVYIPDVFASQGVEEMQKFQLDLQSGRLI
DFIEKPIMKFIAPNQQQRCQDIMHDGEDDQEKDSQQVKIEDAGKKEDDSLVSNSQQVKSA
NKNKVQQQQQQQIATQLTNQELKENLKNGQIQQKQLSLNFESVENNDLSQNKNTNQHDDE
KYAIQLQQELDYMGSKTRKQKNNSQLLISHDYEISSLTQSSRVLRGGRSLCSKPPSQNQR
KKAQQNKITSLKSISESNDSSKQSSKQNPNEAQSPTSSSTTIGVSTNLASPSLQAQQNIK
TKIEQTNVLPSDSQMVIEEQPSTPQQQIDDESSFQFSQKINYKIVSRSNSNSCKKSQLNT
QTTSQQNKTIDENKKIKIKGYISDDDDANDQEEIEKQRIRKEREQQRVKMLEQLEKSQKE
KESETKQITKETKQQKTPSSDYEDNPNIYKRRLNLKQITNSSN