Identifiers and Description

Gene Model Identifier

TTHERM_00402050

Standard Name

COI12 (COnjugation-Induced 12)

Aliases

PreTt12749 | 43.m00267 | 3713.m00093

Description

COI12 anaphase-promoting complex cyclosome subunit 3; A Hsp90 co-chaperone required for the loading of scnRNAs to Twi1p; Tetratricopeptide-like helical domain superfamily

Genome Browser (Macronucleus)

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Genome Browser (Micronucleus)

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External Links

Gene Ontology Annotations

No Data fetched for Gene Ontology Annotations

Domains

  • ( PF12895 ) Anaphase-promoting complex, cyclosome, subunit 3

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

No Data fetched for Homologs

General Information

No. Gene Name(s) Paragraph Text
2311 COI12, GIW1 ATP-dependent and ATP-independent activities of Coi12p facilitate scnRNA loading by counteracting the Twi1p-binding protein Giw1p, which is important for sorting scnRNAs to Twi1p (Woehrer et al. 2015).
2309 COI12 The Tetrahymena Hsp90 co-chaperone Coi12p promotes scnRNA loading into the Argonaute protein Twi1p in both ATP-dependent and ATP-independent manners.
2311 TWI1 ATP-dependent and ATP-independent activities of Coi12p facilitate scnRNA loading by counteracting the Twi1p-binding protein Giw1p, which is important for sorting scnRNAs to Twi1p (Woehrer et al. 2015).

Associated Literature

  1. Ref:29021213: Noto T, Mochizuki K (2017) Whats, hows and whys of programmed DNA elimination in Tetrahymena. Open biology 7(10):
  2. Ref:26688337: Kataoka K, Mochizuki K (2015) Phosphorylation of an HP1-like Protein Regulates Heterochromatin Body Assembly for DNA Elimination. Developmental cell 35(6):775-88
  3. Ref:25588944: Woehrer SL, Aronica L, Suhren JH, Busch CJ, Noto T, Mochizuki K (2015) A Tetrahymena Hsp90 co-chaperone promotes siRNA loading by ATP-dependent and ATP-independent mechanisms. The EMBO journal 34(4):559-77

Sequences 

>TTHERM_00402050(coding)
ATGGATTCATCTAATGAAAACACAAGGAGCTCTTCTTGTAATGAGTAGGAAACTAATTCA
GAACTTTAGTAAAGTGTTAATGAGAGTTGTACCAGCCTAGAAGAGTAGTAATTCAGCACT
CCTTTTTTATCCAGCCAAGAAACTGTATAGGTAGACTAAGCATTCTAAGAATCCACTAAA
TAGAATGAAGGAACTTCTTCTTTCTTAAACGAGACCTAATGCTATCAAGATTGTAAGCCC
AATTTAATTTCTAAAGGAGAGTCAAATCAACAGTAATACAAAGAGTAAACTCAAGAAATT
AGTGAGATTTTAGAAAACCCTTTTGCTTAAAATACACCAACTGATTAATGGAGCATTGTA
GAAGAAAAAGATGGTAATAAACAAGCAGATAGTTTTGATATTTTATAAGACAAATTGATT
AAAGAGGAAACATATAACATCCCTAGTTGGAATTATGAGCCTTAAGATTTTAAAGCAGAT
ATTGACTTTGAAAAATATGACAAAGAAAATCTAGATCACCTAAAGAAAGTCTACAAGCCT
CCATAAATTGAAGACGTCGTCGAAAAAGTAGAATAAGATGAAAATGGGCTTAAAATCTAA
ACTTTATCTTAATTCAATATACCTAAATGCAATATACTGAAGCTTGATATGAGTTTTCTC
TAAACTTGGCAATCAAAAGAAATAGTACCATGCTTTACTATGTTTTCAGAACCAAAAACT
AACAACGGGGAAAGTCTAAATTGTGATGAAGAAGAAACTAATCCTTAGATTGATAAGAAA
TGGTGCAGAGATGTTTAAGTTGTCTTTGAAGAAAGAGATTAGAATGGTGAGCTTATTGAT
AAATATAGAGTTGTCAAAGAAAAAAGAACAGTTAAATTATAAGGAGATATATCAGCAAAG
TGGTATATTTGTCTAGAGCAGATGAAGCCAAATGAAACTAAGTGGTTTAAAATGGAATAA
AAACTTCTTTGGCAGATTGGACAAAAAAATTTAGCTTAATATGAGTGTATTTATCTAAAA
ATATAAATTGTTGGAGTAAAGGCTCTTGCTCTTTCTGAAATGAAAGATAAACTTGAAAAA
AATAACTTACAACCCTAACAGTAAAATATAATCTATGAGGATTATAGTTAAATAGCTCAG
AAATCAGAAGAGTTTAACAATGAAGGAAAAATTCTATTCTCTATTATGAATTATGAAAAA
GCTGCAAAATGGTTTAACAAAGCATTTAGTATTTGGAGAGGAATGAGCAAAAAGCTTAGA
AAAACTTTAAATTCTGAATAGGAATAGAATTATATTGATAAGAGTAACTAGTTTGGTGCT
AATTATGCATAATGCCTTATTAACCTCAAAAAATATTAAGAGTGTGTGGATTTTTACTAA
AAAAACAAGCTTTCTTCTAATAAGAACATTTATAAACTTGTAAAAAGTTTATATGAATTA
CATAACTATGAAAAAGCTATTTAAGTAATAGATAAACAGTTTCCTTAAAATGATGAAAAC
TCAGTTGATAAATTTATGAACGGTAATCAAGAAAGTTTACTTCCAGCTGAATTCTAAAAG
CTTAAAAGTCAGTGTTAAGTAAAGCTAAAAATGTTAGAAAATCAATCAATAAATACATTT
TATAGAAAATTGTTTTAATGA



>TTHERM_00402050(gene)
AAAGTAATTCAATCAATTTCAACAAAAAGATAATTACTTTAATTAGCAAGGCTATTTTAA
ATATTAAAACAAACACTATTATATTAAAAATTAAATAAATTATAATTAAGCATTATTTCA
TTAAAAAATAAATAAAAGACATTAAAATGGATTCATCTAATGAAAACACAAGGAGCTCTT
CTTGTAATGAGTAGGAAACTAATTCAGAACTTTAGTAAAGTGTTAATGAGAGTTGTACCA
GCCTAGAAGAGTAGTAATTCAGCACTCCTTTTTTATCCAGCCAAGAAACTGTATAGGTAG
ACTAAGCATTCTAAGAATCCACTAAATAGAATGAAGGAACTTCTTCTTTCTTAAACGAGA
CCTAATGCTATCAAGATTGTAAGCCCAATTTAATTTCTAAAGGAGAGTCAAATCAACAGT
AATACAAAGAGTAAACTCAAGAAATTAGTGAGATTTTAGAAAACCCTTTTGCTTAAAATA
CACCAACTGATTAATGGAGCATTGTAGAAGAAAAAGATGGTAATAAACAAGCAGATAGTT
TTGATATTTTATAAGACAAATTGATTAAAGAGGAAACATATAACATCCCTAGTTGGAATT
ATGAGCCTTAAGATTTTAAAGCAGATATTGACTTTGAAAAATATGACAAAGAAAATCTAG
ATCACCTAAAGAAAGTCTACAAGCCTCCATAAATTGAAGACGTCGTCGAAAAAGTAGAAT
AAGATGAAAATGGGCTTAAAATCTAAACTTTATCTTAATTCAATATACCTAAATGCAATA
TACTGAAGCTTGATATGAGTTTTCTCTAAACTTGGCAATCAAAAGAAATAGTACCATGCT
TTACTATGTTTTCAGAACCAAAAACTAACAACGGGGAAAGTCTAAATTGTGATGAAGAAG
AAACTAATCCTTAGATTGATAAGAAATGGTGCAGAGATGTTTAAGTTGTCTTTGAAGAAA
GAGATTAGAATGGTGAGCTTATTGATAAATATAGAGTTGTCAAAGAAAAAAGAACAGTTA
AATTATAAGGAGATATATCAGCAAAGTGGTATATTTGTCTAGAGCAGATGAAGCCAAATG
AAACTAAGTGGTTTAAAATGGAATAAAAACTTCTTTGGCAGATTGGACAAAAAAATTTAG
CTTAATATGAGTGTATTTATCTAAAAATATAAATTGTTGGAGTAAAGGCTCTTGCTCTTT
CTGAAATGAAAGATAAACTTGAAAAAAATAACTTACAACCCTAACAGTAAAATATAATCT
ATGAGGATTATAGTTAAATAGCTCAGAAATCAGAAGAGTTTAACAATGAAGGAAAAATTC
TATTCTCTATTATGAATTATGAAAAAGCTGCAAAATGGTTTAACAAAGCATTTAGTATTT
GGAGAGGAATGAGCAAAAAGCTTAGAAAAACTTTAAATTCTGAATAGGAATAGAATTATA
TTGATAAGAGTAACTAGTTTGGTGCTAATTATGCATAATGCCTTATTAACCTCAAAAAAT
ATTAAGAGTGTGTGGATTTTTACTAAAAAAACAAGCTTTCTTCTAATAAGAACATTTATA
AACTTGTAAAAAGTTTATATGAATTACATAACTATGAAAAAGCTATTTAAGTAATAGATA
AACAGTTTCCTTAAAATGATGAAAACTCAGTTGATAAATTTATGAACGGTAATCAAGAAA
GTTTACTTCCAGCTGAATTCTAAAAGCTTAAAAGTCAGTGTTAAGTAAAGCTAAAAATGT
TAGAAAATCAATCAATAAATACATTTTATAGAAAATTGTTTTAATGACTTCTTTTTATTT
GCCTATTTTTATAACATCGTTTTTAAATTTAAATATCTTATTTTTAGTACATTTCTTTTT
TTACTTACTGATTTACTTACTTACTAATAATGAAAAAATAATAATATTTTTTCTTTAATT
TATAATCTTTATAATAAACTTACAACACAACTTCTATTTTAATTATTAT



>TTHERM_00402050(protein)
MDSSNENTRSSSCNEQETNSELQQSVNESCTSLEEQQFSTPFLSSQETVQVDQAFQESTK
QNEGTSSFLNETQCYQDCKPNLISKGESNQQQYKEQTQEISEILENPFAQNTPTDQWSIV
EEKDGNKQADSFDILQDKLIKEETYNIPSWNYEPQDFKADIDFEKYDKENLDHLKKVYKP
PQIEDVVEKVEQDENGLKIQTLSQFNIPKCNILKLDMSFLQTWQSKEIVPCFTMFSEPKT
NNGESLNCDEEETNPQIDKKWCRDVQVVFEERDQNGELIDKYRVVKEKRTVKLQGDISAK
WYICLEQMKPNETKWFKMEQKLLWQIGQKNLAQYECIYLKIQIVGVKALALSEMKDKLEK
NNLQPQQQNIIYEDYSQIAQKSEEFNNEGKILFSIMNYEKAAKWFNKAFSIWRGMSKKLR
KTLNSEQEQNYIDKSNQFGANYAQCLINLKKYQECVDFYQKNKLSSNKNIYKLVKSLYEL
HNYEKAIQVIDKQFPQNDENSVDKFMNGNQESLLPAEFQKLKSQCQVKLKMLENQSINTF
YRKLFQ