Identifiers and Description

Gene Model Identifier

TTHERM_01359440

Standard Name

FLP16 (FLiPpase)

Aliases

PreTt21697 | 346.m00012

Description

FLP16 phospholipid-translocating P-type ATPase flippase family protein

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• integral component of membrane (IEA) | GO:0016021

Molecular Function

• ATP hydrolysis activity (IEA) | GO:0016887

Biological Process

• monoatomic cation transport (IEA) | GO:0006812

Domains

• ( PF00702 ) haloacid dehalogenase-like hydrolase
• ( TIGR00099 ) Cof-like hydrolase
• ( TIGR00338 ) phosphoserine phosphatase SerB
• ( TIGR01116 ) calcium-translocating P-type ATPase, SERCA-type
• ( TIGR01484 ) HAD-superfamily hydrolase, subfamily IIB
• ( TIGR01487 ) SPP-like hydrolase, Archaeal
• ( TIGR01494 ) ATPase, P-type (transporting), HAD superfamily,
• ( TIGR01517 ) calcium-translocating P-type ATPase, PMCA-type
• ( TIGR01652 ) phospholipid-translocating P-type ATPase, flippase

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Stentor Coeruleus	SteCoe_10131	0
	Description: None
Tetrahymena borealis	EI9_14898.1	9.997093137033517e-262
	Description: phospholipid-translocating P-type ATPase, flippase (912 aa)
Oxytricha	Contig10125.0.g35	9.997093137033517e-262
	Description: haloacid dehalogenase-like hydrolase
SGD	YAL026C	4.997959784456982e-159
	Description: DRS2 Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease
DictyBase	DDB_G0269380	2.998986826334339e-156
	Description: DDB_G0269380 on chromosome: 1 position 2645714 to 2650717
WormBase	WBGene00013034	2.9992103642374242e-151
	Description: locus:tat-1 status:Partially_confirmed UniProt:Q9U280 protein_id:CAB11550.4

General Information

No.	Gene Name(s)	Paragraph Text
19	FLP10, FLP19, FLP18, FLP17, FLP8, FLP16, FLP15, FLP14, FLP6, FLP13, FLP11, FLP2, FLP1, DNF1 , FLP9, FLP12, FLP4, FLP7, FLP5	The phospholipid flippase family of genes in Tetrahymena contains 20 members, FLP1-FLP20. Preliminary studies show that many of these genes are differentially regulated in response to temperature and/or the presence of a polycyclic aromatic hydrocarbon (pyrene).

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_01359440(coding)
ATGTAGATTTATTAAGTCGATAAGGTAAATAAGATCCAAAATTCTTATGAGAATGCAATA
GAAAAGCCATATCTATACTGCTTTAAAAAGAAAGTAGCAAGAAAGTAGGAACTTAGGTCA
GTTTACGCAGGAATACCTGATAATTAGGTTTGCAATAATAGGATTTAGACATCAAAATAC
AATTATTTAACCTTCATTCCTAAGAATTTACTAGTTTAGTTTAGCAAACTCGCAAATATA
TACTTTATTATTATTGGTATTTGTCAAATCATACCTTAAATTACTACTACTGATGGAAAG
CCTCTCGTTTATACTCCTTTAGGCATAATTATTTTTATAAGTATGGTAAAGGATTTTATC
GAAGATAGAAAAAGGAGAAAACAAGATGAATATGAAAATAAATCTTTAACAAACAGGTTT
AATGCTTCGTCCGGGGAATTTGAAAAAGTAGCATGGGAAGAACTTACAATTGGCGATATT
ATTAAAGTTGACTTAAATGAGCGATTTCCTGCTGACATTTTGATTCTTTCTACTACTAAT
CAATATGGAAATTGTTATGTTGAGACCAAAAATTTAGATGGAGAAACAAATTTAAAGCTG
AGACAGAGTTGTGCATCTCTCATTTTTACTGATGAAAATGCTGTTAAGAATGTAAACAAT
ATTGGGAGATTTTAATTTTAATATGAAGACCCAAATTATCGCATACACAGTTTCAATGGA
ATAATGATGGATGAACAAGAGAAAGATCCTTCAAAAAGCAAATATCCTCTTTCTTTGTAA
AATATATGCTTGAGAGGATGCACTCTTAAACGTACTCACTCGATTACAGCTGTTGTTATA
TATTCTGGACACGATTGCAAGTCTTTGAAATATGCCTAAAGAGGACACTATAAATTTGGC
ACAGTTGAAAAGATGATGAACAAAATGGTTTTTTATATTTTCTTGATCCTTATATTAATA
AGCATATTCTGTGCTGCTTATTATGTGATTTGGTATAGCTACAAAAAAGACGAACTTACT
TACCTTCATATAGGAGAACATGACATTGAGTCTTACCCTGCAGGAGATTTCTTTCTCAGA
ATTCCAATGTGGGTTTTACTCCTAAGTAACTTTGTTCCCATATCGCTTCTAGTAACTCTT
GAAATTGTGAAGTATCTCCAAGGATAGCTGTTAACAAGAGACAAAAATTTTGTAAATAAA
TTAAGTGACGAACTAGTAGAAGTAAATAGTAGTAATTTGATAGATTAGCTTGGACAAGTC
AGGTACATCCTCACTGATAAAACAGGTACGTTGACTGGAAATGTTATGAAATTCAAAGCA
TTATCTGTCAATAGCAACTCTTACGAGCATACTGCATATGACGATAATGGAATTCTTAAT
AGTACAAAGTTGCTTGAGTAATTAAAGGATTCATCAGAAAATCAACTTGAATATGAAGCT
CTTCTATGCATGAATTTATGCCATGAATTGATGATCGAGTTCGTTGATGGTAAAAAACTC
TATCTAGGAACAAGCCCTGATGAAGAATGCATTATGGAATTTTGCTTAAATACAGGAATA
TATTTAGATAGTATTGATGAACATAAAGTTATGACTATTATAGATTCTATCAATGGAAGA
ACCATACAATTTAAGCTTATTGCTATTCATGAGTATCGCTCAGAGTTAAGGAAAATGTCA
GTTCTAGTGTAGAATCTATAGACAAAGCAATATAAAATATATTAAAAAGGAGCTATGAAT
ACAATTTTCGACATTTGTTCAGAAGATTAATCTTTTAAAAAGGTGAAAGTTGAGGAGCAT
CTTAATGATTACGCAAACAACATGCTCAGAACTCTTTGTCTTTCTTATAAAAACCTAACT
GAAAAAGAAGTTTCTGATTTTTTGCAAAAGAAAAATGAAGAACTAAGTAAAGGAAACCTA
AATATCTAAGATATAAATGATTAAGTTTTTTCTTTAATTGAAAAAAATCACATTTTGATT
GGTGGAACTGGTGTGAATGATGAATTCGCTGACCAAGTAGTTTCAACACTTGCTAATCTA
AAGAAAGCAGGAATAAAAATCTGGATGATCACTGGAGACAAAAAAGAAACAGCGCTTAGC
ATTGGAATAAAATCCAACATAGTAGAAAAAGATGGTGACTTACAAGTAATTGAAGAAGGA
GTTGAAAATGGGTAAAATGATAATTTTACTATTGAGTAGCTTAAAAAATATAAAAAATAA
TTGTAAGATTAAAAAAAACTCAGCATTGGTATTTCTGGATTAACTTATCATAATATCCAC
ATTTCATAGAATGCAGAGCTTATTGAAAACTTCAATTTTGTCATGAAAAATGCTGATTCA
GTGATAGCCTTCCATTTCACTCCTATTCAGAAAAAGCAATTAGTTGATTTAGTCCATTAA
ATAAGTCCAGGATAGTGCGTTCTATCGATTGGCGATGGTGCTAATGACATCAATATGATC
TAAGCAGCTAACGTAGGAATAGGAATTCGTGGTAAAGAGGGAAGAGAAGCAGCTAAGGCT
TCTGATTTCTCTCTCGCAGAATTCAAACATTTAAATAGATTATTGCTATACACTGGCTAA
GAAGCTTACAGAAAAAATAGTTACCTAATATTCTTTAACTTTTATAAAAATTAAGCTTGG
AATTTAGTTTACTTTTGGTTTAATTTTTATGCTGGTTAGAGTGCCCAATATGTTTATGAT
TAGTGGATGACATAATTTTTTAATTTGTTCTATGTCTCTCTTCCTATTATATTATATGCT
CTTTTCGATGAAATGCATCCTTCAAACGAGTTCTTTTAACCAATCTAAACAAGAAAGAAT
GTTTTAGAGTCAAGGCCCCAAGATTACAAACACCTTACTAACAACCTTATCTTTCAACAA
AAAAACTTTTGGAGTTGGTTTTTCTACGGTTCCTTGCATTCCCTCATAATTATGTTTCTA
TCATTTTTAAGTGTTGGTGAATTCTCTGATAAAAATGGTAAATAAACAAACTTATTTTAC
TAAGGTATGCTAGCTTATACTTGTTGTGTTATTTTAGGAAACCTAAAAGTTTAGTAATTA
CATAGAACACATCACTTTGTTACTTTGTTTTTTATTTATGGTAGCATTGGTTTTTATTTT
ATGAATCTCTACATAGCAAATAAAATAACTACCTTAGATTGTTATGGAGTTATAAATGGC
TTATTCCGTTAAGCAAATACATATTTTGCAATAATGATTATGATTATGATAACTTATGGA
ATTGATTCTGCGTATGAAATATTTAATAAATCAAGAAATAATGCAGATTAGCAATAAAAC
ACCTAATTTTCTCTACAGATGCAAGTCTATCAAGGTTAGAAAGAAAACAATATAATTGTT
TATGATAAATCATCATAATAAGGTTCAGATTAAAATTGCATAGAAGAAAAAGCTAAAAAA
GACTATGATAGCTCTTCTGCAGGAGATATTAACAAAAATCTTCTAATTTATCCATTAAAA
GTTTAAATAAAAGATAATATACTACATGATAATTTAGCTGGAAGTAATTATTAATTAGAA
GAAGACTAACCCTATGATAACGAAGTATCTAACAAAAATAAGAAAAAATAAGTATTATCT
TAGGCTCCCTTATAAAACAAGTAGGCTTCTCCATCTTTGTTAATTTAAAAAGCTGATAAA
AAATGA

>TTHERM_01359440(gene)
ATGTAGATTTATTAAGTCGATAAGGTAAATAAGATCCAAAATTCTTATGAGAATGCAATA
GAAAAGCCATATCTATACTGCTTTAAAAAGAAAGTAGCAAGAAAGTAGGAACTTAGGTCA
GTTTACGCAGGAATACCTGATAATTAGGTTTGCAATAATAGGATTTAGACATCAAAATAC
AATTATTTAACCTTCATTCCTAAGAATTTACTAGTTTAGTTTAGCAAACTCGCAAATATA
TACTTTATTATTATTGGTATTTGTCAAATCATACCTTAAATTACTACTACTGATGGAAAG
CCTCTCGTTTATACTCCTTTAGGCATAATTATTTTTATAAGTATGGTAAAGGATTTTATC
GAAGATAGAAAAAGGAGAAAACAAGATGAATATGAAAATAAATCTTTAACAAACAGGTTT
AATGCTTCGTCCGGGGAATTTGAAAAAGTAGCATGGGAAGAACTTACAATTGGCGATATT
ATTAAAGTTGACTTAAATGAGCGATTTCCTGCTGACATTTTGATTCTTTCTACTACTAAT
CAATATGTAAATTAGTGTATCTATTAATATAAAAATTTAAAGGAAAATACATTGATTTTT
TATATGCAAAATTATATAAAATATTTATGACTCATAAATGAGTTTTTTTTCATTTTTTAA
GGGAAATTGTTATGTTGAGACCAAAAATTTAGATGGAGAAACAAATTTAAAGCTGAGACA
GAGTTGTGCATCTCTCATTTTTACTGATGAAAATGCTGTTAAGAATGTAAACAATATTGG
GAGATTTTAATTTTAATATGAAGACCCAAATTATCGCATACACAGTTTCAATGGAATAAT
GATGGATGAACAAGAGAAAGATCCTTCAAAAAGCAAATATCCTCTTTCTTTGTAAAATAT
ATGCTTGAGAGGATGCACTCTTAAACGTACTCACTCGATTACAGCTGTTGTTATATATTC
TGGACACGATTGCAAGTCTTTGAAATATGCCTAAAGAGGACAGTAAATATCTAAATTATT
TAGAACTATTTCAAACATTTAATTTATTCAAGCTATAAATTTGGCACAGTTGAAAAGATG
ATGAACAAAATGGTTTTTTATATTTTCTTGATCCTTATATTAATAAGCATATTCTGTGCT
GCTTATTATGTGATTTGGTATAGCTACAAAAAAGACGAACTTACTTACCTTCATATAGGA
GAACATGACATTGAGTCTTACCCTGCAGGAGATTTCTTTCTCAGAATTCCAATGTGGGTT
TTACTCCTAAGTAACTTTGTTCCCATATCGCTTCTAGTAACTCTTGAAATTGTGAAGTAT
CTCCAAGGATAGCTGTTAACAAGAGACAAAAATTTTGTAAATAAATTAAGTGACGAACTA
GTAGAAGTAAATAGTAGTAATTTGATAGATTAGCTTGGACAAGTCAGGTACATCCTCACT
GATAAAACAGGTACGTTGACTGGAAATGTTATGAAATTCAAAGCATTATCTGTCAATAGC
AACTCTTACGAGCATACTGCATATGACGATAATGGAATTCTTAATAGTACAAAGTTGCTT
GAGTAATTAAAGGATTCATCAGAAAATCAAGTAATTAATTAATTAATTTTATATGAAATT
TATAACTTAAAATATTGAAATTAGCTTGAATATGAAGCTCTTCTATGCATGAATTTATGC
CATGAATTGATGATCGAGTTCGTTGATGGTAAAAAACTCTATCTAGGAACAAGCCCTGAT
GAAGAATGCATTATGGAATTTTGCTTAAATACAGGAATATATTTAGATAGTATTGATGAA
CATAAAGTTATGACTATTATAGATTCTATCAATGGAAGAACCATACAATTTAAGCTTATT
GCTATTCATGAGTATCGCTCAGAGTTAAGGAAAATGTCAGTTCTAGTGTAGAATCTATAG
ACAAAGCAATATAAAATATATTAAAAAGGAGCTATGAATACAATTTTCGACATTTGTTCA
GAAGATTAATCTTTTAAAAAGGTGAAAGTTGAGGAGCATCTTAATGATTACGCAAACAAC
ATGCTCAGAACTCTTTGTCTTTCTTATAAAAACCTAACTGAAAAAGAAGTTTCTGATTTT
TTGCAAAAGTAATTTGAAAAATATTTTATTTGATTTAAAATGAGATTTTATTTTTGAAAG
GAAAAATGAAGAACTAAGTAAAGGAAACCTAAATATCTAAGATATAAATGATTAAGTTTT
TTCTTTAATTGAAAAAAATCACATTTTGATTGGTGGAACTGGTGTGAATGATGAATTCGC
TGACCAAGTAGTTTCAACACTTGCTAATCTAAAGAAAGCAGGAATAAAAATCTGGATGAT
CACTGGAGACAAAAAAGAAACAGCGCTTAGCATTGGAATAAAATCCAACATAGTAGAAAA
AGATGGTGACTTACAAGTAATTGAAGAAGGAGTTGAAAATGGGTAAAATGATAATTTTAC
TATTGAGTAGCTTAAAAAATATAAAAAATAATTGTAAGATTAAAAAAAACTCAGCATTGG
TATTTCTGGATTAACTTATCATAATATCCACATTTCATAGAATGCAGAGCTTATTGAAAA
CTTCAATTTTGTCATGAAAAATGCTGATTCAGTGATAGCCTTCCATTTCACTCCTATTCA
GAAAAAGCAATTAGTTGATTTAGTCCATTAAATAAGTCCAGGATAGTGCGTTCTATCGAT
TGGCGATGGTGCTAATGACATCAATATGATCTAAGCAGCTAACGTAGGAATAGGAATTCG
TGGTAAAGAGGTAAAGTAATTTGCATGTAATCTTTTAACTAACTATTTTCACTTATGAAA
AAGGGAAGAGAAGCAGCTAAGGCTTCTGATTTCTCTCTCGCAGAATTCAAACATTTAAAT
AGATTATTGCTATACACTGGCTAAGAAGCTTACAGAAAAAATAGTTACCTAATATTCTTT
AACTTTTATAAAAATTAAGCTTGGAATTTAGTTTACTTTTGGTTTAATTTTTATGCTGGT
TAGAGTGCCCAATATGTTTATGATTAGTGGATGACATAATTTTTTAATTTGTTCTATGTC
TCTCTTCCTATTATATTATATGCTCTTTTCGATGAAATGCATCCTTCAAACGAGTTCTTT
TAACCAATCTAAACAAGAAAGAATGTTTTAGAGTCAAGGCCCCAAGATTACAAACACCTT
ACTAACAACCTTATCTTTCAACAAAAAAACTTTTGGAGTTGGTTTTTCTACGGTTCCTTG
CATTCCCTCATAATTATGTTTCTATCGTAAAAATTTTTATCTTTATTTATTTATTATTGA
TTTTAAATAATTTTTATTTAAACAAATAAATTAATTTTTCCATTTAATTCAATTAAAGCT
ATAAACTGCCATATTTTTTTAAAAGCCAAGTGATATAAATATTTTTATTCAAAATAATCT
ACTCTAATCTTTATTTCTTTTATGGTAGCTTAATTAAAAAAATAACATTTATGAAAAAAA
ATATAAAATTTATGAAATTTTTTGCAATTATTTAAAATAAATAAAAAATAAAATAATTTA
AAGTATATTTAAAAAATGTTAATAATTAATTAGATTTTTAAGTGTTGGTGAATTCTCTGA
TAAAAATGGTAAATAAACAAACTTATTTTACTAAGGTATGCTAGCTTATACTTGTTGTGT
TATTTTAGGAAACCTAAAAGTTTAGTAATTACATAGAACACATCACTTTGTTACTTTGTT
TTTTATTTATGGTAGCATTGGTTTTTATTTTATGAATCTCTACATAGCAAATAAAATAAC
TACCTTAGATTGTTATGGAGTTATAAATGGCTTATTCCGTTAAGCAAATACATATTTTGC
AATAATGATTATGATTATGATAACTTATGGAATTGATTCTGCGTATGAAATATTTAATAA
ATCAAGAAATAATGCAGATTAGCAATAAAACACCTAATTTTCTCTACAGATGCAAGTCTA
TCAAGGTTAGAAAGAAAACAATATAATTGTTTATGATAAATCATCATAATAAGGTTCAGA
TTAAAATTGCATAGAAGAAAAAGCTAAAAAAGACTATGATAGCTCTTCTGCAGGAGATAT
TAACAAAAATCTTCTAATTTATCCATTAAAAGTTTAAATAAAAGATAATATACTACATGA
TAATTTAGCTGGAAGTAATTATTAATTAGAAGAAGACTAACCCTATGATAACGAAGTATC
TAACAAAAATAAGAAAAAATAAGTATTATCTTAGGCTCCCTTATAAAACAAGTAGGCTTC
TCCATCTTTGTTAATTTAAAAAGCTGATAAAAAATGA

>TTHERM_01359440(protein)
MQIYQVDKVNKIQNSYENAIEKPYLYCFKKKVARKQELRSVYAGIPDNQVCNNRIQTSKY
NYLTFIPKNLLVQFSKLANIYFIIIGICQIIPQITTTDGKPLVYTPLGIIIFISMVKDFI
EDRKRRKQDEYENKSLTNRFNASSGEFEKVAWEELTIGDIIKVDLNERFPADILILSTTN
QYGNCYVETKNLDGETNLKLRQSCASLIFTDENAVKNVNNIGRFQFQYEDPNYRIHSFNG
IMMDEQEKDPSKSKYPLSLQNICLRGCTLKRTHSITAVVIYSGHDCKSLKYAQRGHYKFG
TVEKMMNKMVFYIFLILILISIFCAAYYVIWYSYKKDELTYLHIGEHDIESYPAGDFFLR
IPMWVLLLSNFVPISLLVTLEIVKYLQGQLLTRDKNFVNKLSDELVEVNSSNLIDQLGQV
RYILTDKTGTLTGNVMKFKALSVNSNSYEHTAYDDNGILNSTKLLEQLKDSSENQLEYEA
LLCMNLCHELMIEFVDGKKLYLGTSPDEECIMEFCLNTGIYLDSIDEHKVMTIIDSINGR
TIQFKLIAIHEYRSELRKMSVLVQNLQTKQYKIYQKGAMNTIFDICSEDQSFKKVKVEEH
LNDYANNMLRTLCLSYKNLTEKEVSDFLQKKNEELSKGNLNIQDINDQVFSLIEKNHILI
GGTGVNDEFADQVVSTLANLKKAGIKIWMITGDKKETALSIGIKSNIVEKDGDLQVIEEG
VENGQNDNFTIEQLKKYKKQLQDQKKLSIGISGLTYHNIHISQNAELIENFNFVMKNADS
VIAFHFTPIQKKQLVDLVHQISPGQCVLSIGDGANDINMIQAANVGIGIRGKEGREAAKA
SDFSLAEFKHLNRLLLYTGQEAYRKNSYLIFFNFYKNQAWNLVYFWFNFYAGQSAQYVYD
QWMTQFFNLFYVSLPIILYALFDEMHPSNEFFQPIQTRKNVLESRPQDYKHLTNNLIFQQ
KNFWSWFFYGSLHSLIIMFLSFLSVGEFSDKNGKQTNLFYQGMLAYTCCVILGNLKVQQL
HRTHHFVTLFFIYGSIGFYFMNLYIANKITTLDCYGVINGLFRQANTYFAIMIMIMITYG
IDSAYEIFNKSRNNADQQQNTQFSLQMQVYQGQKENNIIVYDKSSQQGSDQNCIEEKAKK
DYDSSSAGDINKNLLIYPLKVQIKDNILHDNLAGSNYQLEEDQPYDNEVSNKNKKKQVLS
QAPLQNKQASPSLLIQKADKK