Identifiers and Description

Gene Model Identifier

TTHERM_01000180

Standard Name

CSKA2 (CaSein Kinase Alpha subunit 2)

Aliases

PreTt15737 | 190.m00047 | 3820.m00272

Description

CSKA2 Casein kinase II alpha subunit; Protein kinase domain containing protein; Sequence similarity to the CK2 protein kinase family (Eisen et al. 2006); Tetrahymena CKII-complex appears to have two alpha subunits and one regulatory beta subunit (Nabeel-Shah et al., 2023); Casein Kinase 2, subunit alpha

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Gene Ontology Annotations

No Data fetched for Gene Ontology Annotations

Domains

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

No Data fetched for Homologs

General Information

No. Gene Name(s) Paragraph Text
2356 CSKB1, CSKA2, CSKA1 CKII subunits including CSKA1, CSKA2, and CSKB1 co-purified with Cac2 subunit of putative CAF1-complex in Tetrahymena. Tetrahymena appears to contain a single putative homolog of the two regulatory beta subunits of CKII that are found in humans. Affinity purification followed by mass spectrometry (AP-MS) analysis of TTHERM_00780530 (CSKB1) identified a large number of proteins to co-purify, suggesting that CKII clients might include functionally diverse proteins in Tetrahymena (Nabeel-Shah et al., 2023).
2357 CSKB1, CSKA2, CSKA1 CKII subunits including CSKA1, CSKA2, and CSKB1 co-purified with Cac2 subunit of putative CAF1-complex in Tetrahymena. Tetrahymena appears to contain a single putative homolog of the two regulatory beta subunits of CKII that are found in humans. Affinity purification followed by mass spectrometry (AP-MS) analysis of TTHERM_00780530 (CSKB1) identified a large number of proteins to co-purify, suggesting that CKII clients might include functionally diverse proteins in Tetrahymena (Nabeel-Shah et al., 2023).
2358 CSKB1, CSKA2, CSKA1 CKII subunits including CSKA1, CSKA2, and CSKB1 co-purified with Cac2 subunit of putative CAF1-complex in Tetrahymena. Tetrahymena appears to contain a single putative homolog of the two regulatory beta subunits of CKII that are found in humans. Affinity purification followed by mass spectrometry (AP-MS) analysis of TTHERM_00780530 (CSKB1) identified a large number of proteins to co-purify, suggesting that CKII clients might include functionally diverse proteins in Tetrahymena (Nabeel-Shah et al., 2023).

Associated Literature

  1. Ref:37024975: Nabeel-Shah S, Garg J, Ashraf K, Jeyapala R, Lee H, Petrova A, Burns JD, Pu S, Zhang Z, Greenblatt JF, Pearlman RE, Lambert JP, Fillingham J (2023) Multilevel interrogation of H3.3 reveals a primordial role in transcription regulation. Epigenetics & chromatin 16:10
  2. Ref:16933976: Eisen JA, Coyne RS, Wu M, Wu D, Thiagarajan M, Wortman JR, Badger JH, Ren Q, Amedeo P, Jones KM, Tallon LJ, Delcher AL, Salzberg SL, Silva JC, Haas BJ, Majoros WH, Farzad M, Carlton JM, Smith RK, Garg J, Pearlman RE, Karrer KM, Sun L, Manning G, Elde NC, Turkewitz AP, Asai DJ, Wilkes DE, Wang Y, Cai H, Collins K, Stewart BA, Lee SR, Wilamowska K, Weinberg Z, Ruzzo WL, Wloga D, Gaertig J, Frankel J, Tsao CC, Gorovsky MA, Keeling PJ, Waller RF, Patron NJ, Cherry JM, Stover NA,

Sequences 

>TTHERM_01000180(coding)
ATGGATTACAAAGTAATAAGCTCAAAACCAAAATTTTATGCAGATGCAAATTTAAAAAAA
TCAGCTGAATACTATGACTATGAAAACTTAGAAATAGAATGGGGTGAATAGGAAAACTAT
GAAGTGATAAGAAAGTTAGGAAGAGGTAAATATTCCGAAGTTTTCGAAGGAATCAACTCT
TTGAATAATGAGAAATGCGTTATTAAAGTCCTTAAGCCAATCAGAAAGAAAAAAATAAAG
AGAGAAATCTCTATTTTAAAGAATCTTAGTGGAGGCCCTAACATTGTTTAACTTCTTGAC
ATAGTAAAGGATCCTGCTTCTAAGTGCACTTCATTTGTTTTTGAGTATGTAAACAATATT
GATTACAGAGAGCTTTATCCAAAGTTAAGCGATTTTGATGTTAGATTTTATATTTTTGAA
GTGCTAAAGGCTTTAGATTTTTGTCATAGTTAAGGTATTATGCATAGAGATGTAAAACCA
CATAATATTATGATAGATCATGAAAAGAAATAACTAAGACTCATAGATTGGGGTTTGGCT
GAGTACTACTTCCCAGGAAAAGATTATAATGTAAGAGTAGCTTCAAGATATTTTAAAGGG
CCTGAATTGTTAGTAGATTACTAATACTATGATTACAGTTTGGATATTTGGAGCTTGGGT
GCTATGTTTGCTGGTATGATTTTCAAAAAAGAACCATTCTTCTAAGGAAACGATAACTAT
GATTAACTTGAAAAGATAGCAAGAGTCCTTGGTACAAATGAATTATATGATTATCTAAAT
ACATATAACCTCGAGTTAGATCCTAAATTTGAAGGAATTTTGGGCAAGCATACAAAGAAA
CCTTGGTCAAAGTTTGTTAATAATGACAATAAGAATTTAGCAGTAAATGAAGCAATTGAC
CTTCTATCAAAGATGCTTGTTTATGATCATGCTTAAAGAATAACACCTAAAGAAGCCATG
CAACATGCTTATTTCTTCCCTATCTTGTAATACCATGAAAAAAACTCTAAGCCTGAAGAA
TCAAATAAAAAATGA



>TTHERM_01000180(gene)
ATCTACTTAAATTAATTATTAAAAATGCATAAAAAATCAAACATTTCTTAGATTTCAAAA
GAAAAAAATCAAATTTTAATATATAATAAAATCTTAAAAAGATAAATAATTAATATTTGA
AACAAGAATTTAATTTAAAATATCCAGTTTTTAAAAATGGATTACAAAGTAATAAGCTCA
AAACCAAAATTTTATGCAGATGCAAATTTAAAAAAATCAGCTGAATACTATGACTATGAA
AACTTAGAAATAGAATGGGGTGAATAGGAAAACTATGAAGTGATAAGAAAGTTAGGAAGA
GGTAAATATTCCGAAGTTTTCGAAGGAATCAACTCTTTGAATAATGAGAAATGCGTTATT
AAAGTCCTTAAGCCAATCAGAAAGAAAAAAATAAAGAGAGAAATCTCTATTTTAAAGAAT
CTTAGTGGAGGCCCTAACATTGTTTAACTTCTTGACATAGTAAAGGATCCTGCTTCTAAG
TGCACTTCATTTGTTTTTGAGTATGTAAACAATATTGATTACAGAGAGCTTTATCCAAAG
TTAAGCGATTTTGATGTTAGATTTTATATTTTTGAAGTGCTAAAGGCTTTAGATTTTTGT
CATAGTTAAGGTATTATGCATAGAGATGTAAAACCACATAATATTATGATAGATCATGAA
AAGAAATAACTAAGACTCATAGATTGGGGTTTGGCTGAGTACTACTTCCCAGGAAAAGAT
TATAATGTAAGAGTAGCTTCAAGATATTTTAAAGGGCCTGAATTGTTAGTAGATTACTAA
TACTATGATTACAGTTTGGATATTTGGAGCTTGGGTGCTATGTTTGCTGGTATGATTTTC
AAAAAAGAACCATTCTTCTAAGGAAACGATAACTATGATTAACTTGAAAAGATAGCAAGA
GTCCTTGGTACAAATGAATTATATGATTATCTAAATACATATAACCTCGAGTTAGATCCT
AAATTTGAAGGAATTTTGGGCAAGCATACAAAGAAACCTTGGTCAAAGTTTGTTAATAAT
GACAATAAGAATTTAGCAGTAAATGAAGCAATTGACCTTCTATCAAAGATGCTTGTTTAT
GATCATGCTTAAAGAATAACACCTAAAGAAGCCATGCAACATGCTTATTTCTTCCCTATC
TTGTAATACCATGAAAAAAACTCTAAGCCTGAAGAATCAAATAAAAAATGAAAAACTAAA
AGATATAAAAATAGTATCATTTTAAGCAAATATTTTTGCGCATCTTGATCTAGCTCAATA
AATTATATTGATTGCTATCTGCACAAAAATTATGACATTAAAACTTACTTACTTTTTTAA
CAAAAATTATAATAAGAGTTAATTTTGATTTGTAAATCCTTTTATATAGTAATTAATATT
TTAAGTTAATTTTCTTATTAATTCATTTCTAGCCTACTTATTATATATGTATTTATTATT
ATAAAT



>TTHERM_01000180(protein)
MDYKVISSKPKFYADANLKKSAEYYDYENLEIEWGEQENYEVIRKLGRGKYSEVFEGINS
LNNEKCVIKVLKPIRKKKIKREISILKNLSGGPNIVQLLDIVKDPASKCTSFVFEYVNNI
DYRELYPKLSDFDVRFYIFEVLKALDFCHSQGIMHRDVKPHNIMIDHEKKQLRLIDWGLA
EYYFPGKDYNVRVASRYFKGPELLVDYQYYDYSLDIWSLGAMFAGMIFKKEPFFQGNDNY
DQLEKIARVLGTNELYDYLNTYNLELDPKFEGILGKHTKKPWSKFVNNDNKNLAVNEAID
LLSKMLVYDHAQRITPKEAMQHAYFFPILQYHEKNSKPEESNKK