Identifiers and Description

Gene Model Identifier

TTHERM_01345800

Standard Name

CSKA1 (CaSein Kinase Alpha subunit 1)

Aliases

PreTt01649 | 337.m00014 | 3805.m00068

Description

CSKA1 Casein kinase II alpha subunit; Protein kinase domain containing protein; Sequence similarity to a protein kinase family unique to Tetrahymena thermophila (Eisen et al. 2006); Casein Kinase 2, subunit alpha

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External Links

Gene Ontology Annotations

No Data fetched for Gene Ontology Annotations

Domains

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

No Data fetched for Homologs

General Information

No. Gene Name(s) Paragraph Text
2356 CSKB1, CSKA2, CSKA1 CKII subunits including CSKA1, CSKA2, and CSKB1 co-purified with Cac2 subunit of putative CAF1-complex in Tetrahymena. Tetrahymena appears to contain a single putative homolog of the two regulatory beta subunits of CKII that are found in humans. Affinity purification followed by mass spectrometry (AP-MS) analysis of TTHERM_00780530 (CSKB1) identified a large number of proteins to co-purify, suggesting that CKII clients might include functionally diverse proteins in Tetrahymena (Nabeel-Shah et al., 2023).
2357 CSKB1, CSKA2, CSKA1 CKII subunits including CSKA1, CSKA2, and CSKB1 co-purified with Cac2 subunit of putative CAF1-complex in Tetrahymena. Tetrahymena appears to contain a single putative homolog of the two regulatory beta subunits of CKII that are found in humans. Affinity purification followed by mass spectrometry (AP-MS) analysis of TTHERM_00780530 (CSKB1) identified a large number of proteins to co-purify, suggesting that CKII clients might include functionally diverse proteins in Tetrahymena (Nabeel-Shah et al., 2023).
2358 CSKB1, CSKA2, CSKA1 CKII subunits including CSKA1, CSKA2, and CSKB1 co-purified with Cac2 subunit of putative CAF1-complex in Tetrahymena. Tetrahymena appears to contain a single putative homolog of the two regulatory beta subunits of CKII that are found in humans. Affinity purification followed by mass spectrometry (AP-MS) analysis of TTHERM_00780530 (CSKB1) identified a large number of proteins to co-purify, suggesting that CKII clients might include functionally diverse proteins in Tetrahymena (Nabeel-Shah et al., 2023).

Associated Literature

  1. Ref:37024975: Nabeel-Shah S, Garg J, Ashraf K, Jeyapala R, Lee H, Petrova A, Burns JD, Pu S, Zhang Z, Greenblatt JF, Pearlman RE, Lambert JP, Fillingham J (2023) Multilevel interrogation of H3.3 reveals a primordial role in transcription regulation. Epigenetics & chromatin 16:10

Sequences 

>TTHERM_01345800(coding)
ATGTTAAAAAATTTAATAAAAAATATATTTATAAGTGGAAAAAGCAGCTTCCAATAAATA
TATAAAAATAATAGAATACAATATAATTTCTGTCAAGCAACAACTACAATGAACTAGTAG
TAAAAAAGTGTACTTCCAAAGTATTATGCTAATGTGAATGAATTCATGCCAAAGGATTAT
TCAAATTACGAAGACTATGAAAACGAATGGGGAAATCAAGACGATTATGAAGTAATCCGC
AAATTAGGAAGAGGTAAATACTCTGAAGTCTTTGATGGAATTAGCGTTGTAACAAAGAAA
AGAGTAGTTATTAAGGTCCTCAAGCCAGTTAAAAAGCGCAAAATTAAAAGAGAAATCAAG
ATTTTATAGATTTTGAAGGGAGGTCCAAATATTGTTGAATTGTTAGACGTAGTTCGTGAC
CCTGCCTCAAAAACTCCTTCACTTATCTTTGAATAAATTGAAAATGTCGACTTTAGAAGC
TAGTTCCCAAACTTGACAGACTTAGAAATTAAATTCTATATGTTCGAAATTTTGAAAGCA
TTAGATTATTGTCATAGCAAAGGTATTATGCATAGAGATGTTAAGCCATAGAATATAATT
GTAGATCCCAAAAATAAAATTCTCAAATTAATTGATTGGGGTCTAGCTGAATTCTATCAC
CCTGGAACAGATTATAATGTTAGAGTTGCTTCTCGTTATTTCAAGGGTCCTGAATTGCTT
GTTGATCAAAATTACTATGATTATTCACTCGATATTTGGAGTACAGGAACTATGTTTGCA
TCTATGATTTTCAAGAAAGAGCCTTTCTTCTAAGGTGCAGACAACTAAGACTAATTAATA
AAAATTGCTAAAGTTTTAGGTACAGAAGACTTACATAAATATCTTAGAAAATACGATTTA
ACATTAGATGTTAGTTATCATAAGATTCTTGGAAGTTACGCTAAGAAGCCTTGGGTCAAA
TTCATTACAGAAGAAAATAAACATCTTTGCCATGAATAAGCTATTGATCTTCTTTCTAAG
ATGTTAATCTATGATAATGCTTTAAGAATTACACCTAAGGATGCTATGGAACACCCTTAT
TTTGATTAAGTTCGTACTCTCACTCCTACTGGTCTTATTAATCTATTAAAACAATAATAA
AATCAATAGTGA



>TTHERM_01345800(gene)
AAGTAAAATTAGAAGCAGTTTTTACTTAGAAAATGTTAAAAAATTTAATAAAAAATATAT
TTATAAGTGGAAAAAGCAGCTTCCAATAAATATATAAAAATAATAGAATACAATATAATT
TCTGTCAAGCAACAACTACAATGAACTAGTAGTAAAAAAGTGTACTTCCAAAGTATTATG
CTAATGTGAATGAATTCATGCCAAAGGATTATTCAAATTACGAAGACTATGAAAACGAAT
GGGGAAATCAAGACGATTATGAAGTAATCCGCAAATTAGGAAGAGGTAAATACTCTGAAG
TCTTTGATGGAATTAGCGTTGTAACAAAGAAAAGAGTAGTTATTAAGGTCCTCAAGCCAG
TTAAAAAGCGCAAAATTAAAAGAGAAATCAAGATTTTATAGATTTTGAAGGGAGGTCCAA
ATATTGTTGAATTGTTAGACGTAGTTCGTGACCCTGCCTCAAAAACTCCTTCACTTATCT
TTGAATAAATTGAAAATGTCGACTTTAGAAGCTAGTTCCCAAACTTGACAGACTTAGAAA
TTAAATTCTATATGTTCGAAATTTTGAAAGCATTAGATTATTGTCATAGCAAAGGTATTA
TGCATAGAGATGTTAAGCCATAGAATATAATTGTAGATCCCAAAAATAAAATTCTCAAAT
TAATTGATTGGGGTCTAGCTGAATTCTATCACCCTGGAACAGATTATAATGTTAGAGTTG
CTTCTCGTTATTTCAAGGGTCCTGAATTGCTTGTTGATCAAAATTACTATGATTATTCAC
TCGATATTTGGAGTACAGGAACTATGTTTGCATCTATGATTTTCAAGAAAGAGCCTTTCT
TCTAAGGTGCAGACAACTAAGACTAATTAATAAAAATTGCTAAAGTTTTAGGTACAGAAG
ACTTACATAAATATCTTAGAAAATACGATTTAACATTAGATGTTAGTTATCATAAGATTC
TTGGAAGTTACGCTAAGAAGCCTTGGGTCAAATTCATTACAGAAGAAAATAAACATCTTT
GCCATGAATAAGCTATTGATCTTCTTTCTAAGATGTTAATCTATGATAATGCTTTAAGAA
TTACACCTAAGGATGCTATGGAACACCCTTATTTTGATTAAGTTCGTACTCTCACTCCTA
CTGGTCTTATTAATCTATTAAAACAATAATAAAATCAATAGTGATCATCTAGTTATCTAA
ATAAAGCTCATATTTTTTTACCTTACTATAATTTACATAATATAATGATATATCTATCTA
TCAATCAATAAATCAATCAATCATTGCTCTTTTGTATATGTTTTCTAAAAGTATTTCAAA
GAGAATATAATAATTGCATTTTCGTCAAA



>TTHERM_01345800(protein)
MLKNLIKNIFISGKSSFQQIYKNNRIQYNFCQATTTMNQQQKSVLPKYYANVNEFMPKDY
SNYEDYENEWGNQDDYEVIRKLGRGKYSEVFDGISVVTKKRVVIKVLKPVKKRKIKREIK
ILQILKGGPNIVELLDVVRDPASKTPSLIFEQIENVDFRSQFPNLTDLEIKFYMFEILKA
LDYCHSKGIMHRDVKPQNIIVDPKNKILKLIDWGLAEFYHPGTDYNVRVASRYFKGPELL
VDQNYYDYSLDIWSTGTMFASMIFKKEPFFQGADNQDQLIKIAKVLGTEDLHKYLRKYDL
TLDVSYHKILGSYAKKPWVKFITEENKHLCHEQAIDLLSKMLIYDNALRITPKDAMEHPY
FDQVRTLTPTGLINLLKQQQNQQ