TGD | Tetrahymena Genome Database Wiki

Identifiers and Description

Gene Model Identifier
TTHERM_01035740

Standard Name
MYO2 (MYOsin )

Aliases
PreTt09585 | 206.m00058

Description
MYO2 myosin head protein; Myosin heavy chain; member of proposed myosin Class XX- distinct from previously defined myosin classes; contains predicted coiled-coil- myosin tail homology (MyTH4)- and FERM domains

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

Uniprot

Alphafold

Gene Ontology Annotations

Cellular Component
myosin complex (ISS) | GO:0016459
myosin complex (IEA) | GO:0016459
Molecular Function
ATP binding (ISS) | GO:0005524
ATP binding (IEA) | GO:0005524
cytoskeletal motor activity (ISS) | GO:0003774
cytoskeletal motor activity (IEA) | GO:0003774

Domains

( PF00063 ) Myosin head (motor domain)
( PF00612 ) IQ calmodulin-binding motif
( PF00784 ) MyTH4 domain
( TIGR00088 ) tRNA (guanine-N1)-methyltransferase
( TIGR01612 ) rhoptry protein

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source Identifier Score

Tetrahymena borealis EI9_19646.1 9.997093137033517e-262

Description: myosin head, motor domain-containing protein (1543 aa)

Oxytricha Contig18292.0.g108 4.999822746981985e-134

Description: Myosin head (motor domain)

DictyBase DDB_G0288679 9.997006461365152e-115

Description: myoE on chromosome: 5 position 1829072 to 1832587

SGD YOR326W 2.0009157491910723e-107

Description: MYO2 One of two type V myosin motors (along with MYO4) involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle

WormBase WBGene00002038 1.0002646133906571e-103

Description: locus:hum-5 status:Confirmed UniProt:G5ECZ0 protein_id:CAA84673.1

General Information

No. Gene Name(s) Paragraph Text

10 MYO1, MYO2, MYO3, MYO4, MYO5, MYO4 , MYO9, MYO10, MYO11, MYO12, MYO13 Proteins of the myosin superfamily are ATP-dependent molecular motors that travel unidirectionally along actin filaments. The myosin heavy chain proteins are comprised of three domains: a head (motor) domain responsible for ATP hydrolysis at the N-terminus, a neck (lever arm) region, and a C-terminal tail region. Thirteen predicted myosin heavy chain genes have been identified in the Tetrahymena genome and named MYO1-MYO13. A phylogenetic analysis comparing these predicted proteins with the 19 previously identified myosin classes suggests that Myo1p-Myo12p belong to a previously undescribed class of myosins. This new family, designated Class XX, does not include Myo13p, which did not branch with this class or any of the other classes in the analysis. The neck and tail regions of the Tetrahymena myosins include a variety of domains characterized in other myosin classes, with each protein containing one or more of the following domains: coiled-coil (which may support dimerization); IQ motif (binding sites for calmodulin or calmodulin-like proteins); FERM domain (Four-point-one protein, Ezrin, Radixin, Moesin homology); and MyTH4 domain (Myosin Tail Homology 4).

Associated Literature

Ref:16505385: Foth BJ, Goedecke MC, Soldati D (2006) New insights into myosin evolution and classification. Proceedings of the National Academy of Sciences of the United States of America 103(10):3681-6
Ref:15988740: Williams SA, Gavin RH (2005) Myosin genes in Tetrahymena. Cell motility and the cytoskeleton 61(4):237-43
Ref:17821280: Harrison JA, Fowler EH (1945) AN ANTIGEN-ANTIBODY REACTION WITH TETRAHYMENA WHICH RESULTS IN DYSTOMY. Science (New York, N.Y.) 102(2638):65-6

Sequences

>TTHERM_01035740(coding)
ATGAGTATTGATTCACATTAAATAGAAAGAATTAAGACATCATGGATGCTTAATGGAGTT
TAATGCTGGGCTAAAGTAGCACCAGAGGAAAACTCCGAGCTTATGTTTCGTAGGGCTATT
ATTACAGGTTTAGATAATAAGCGTGAGCATGCATTCTTAAAATATGAGTTTCATCTTATC
TAAATTTAACAGCAAAAAGAAAAAGGTCCAGAAAAAGTACATGTTAGAGACTTAATAGAA
TGCAATTAGAATGCAGATAGTGAAAAATTTAAAGAAGGTTTTCCTGATATGGTTTCGATG
AATGTATTAAATGAAGCAGAAATTTTGAATAATGTTTGGTTGCGATATTCTAAAGACCTA
ATTTTTTCCTACATAGGACCTACATTAATTGTAATGAATCCCTACAAGAATGTAGAAAAG
CTTTTTAATGAAAAGGTTTTATAAGAATTTTAGAAACCTGCAATAAATAACAATTTCGAT
ATAAAGTAGCATTAGCCTCATGTCTATGCAGTAACTACATTAGCTTATTAGTAGCTATTT
ATGAATTAAAAGAACCAGGCAATAGTAATTAGTGGAGAATCAGGAGCTGGTAAGACTGAA
AATGCTAAATATTGTATGGCTTTTTTAACTTCTTTAAGTAATGAAACAACTAAGCAGTAA
CGCCCAAAAAAGAAAACTTAATTGGCGAACTAATTAAATAGATATTCTACAATGAGATAT
TCTTCAGTAGTAGCTAGCAACATCTCAGATTCTTAATATACTGAAGACTCTATACTTTAA
TTAAAGGATACATCGATTGAAGAGCGTATTCTTAGATGCAACCCAATTTTGGAAGCGTTT
GGTAATGCTAAAACAGTGAGAAATGATAATTCAAGTAGATTTGGTAAATATGTTCGTATT
TGGATTGGAAAGCATGATAAAAGAATTAAAGGAGCCTCAATTACAAATTACTTATTAGAA
AAAAGTAGAGTGACTCTACTATCATAAGGTGAAAGAAACTATCACATATTCTATCATTTT
TTATAAGGATTAGAAACTTCACAACTTAAAACTTATAAACTTGTGGAAAAAAATGGTAAT
AGAATAGATTTAAAAAATTTTAATTATTTAAATTAAACTAATGTGTACGAAATAAGCTCC
TTTCCTAGTGATAAAATAATGATTGATTAGATTATTGAATCCTTTGAGAAAATGGAGATT
GATTCATACTAGTAAGTAGCTATTTTTAAAGTTTTATCAGCTATTCTTTATATTGGAAAT
ATTGAGTTTGATAGCTCAACATATACAGATAATACTCCTTGTAGTATAAAAAACTAAGAT
ATCATATAAACTGTTTCTGAACTTTTAGAAATAAATTAGTAAGATAAAATTTTGAAGTCA
ATTATATTTAAAATACGTTAAGTTGGTAGCTAGGTTATGGAAACTCCAGTGAATGTTGAA
GAGTGCAAAATTAATAGGGATTCATTAGCGAGAGCTCTTTATGATAAAATGTTTACATGG
ATAGTTTAATCATTAAATATGGAAATTTTACCTTAGAATAGTAATCCTAACGAATGTTTA
AGTCTCGGATTGCTAGATATTTTTGGGTTTGAGAACTTTAAGGTCAATTCTTTTGAATAA
TTATGCATCAACTTCACAAATGAGCGCTTGCAATAGCTATATATTGTATATGTGTTTAAA
GCTGAAGAAGAAGAGTTTAAAAAAGAAGGTCTTAAAGTCCATAGCTTAGAACTTTCTTAT
TAAGATAATTAAGTTATTATAGATACAATGGATAAGCCACCTAATGGTATTTTTGATCTT
CTAGATGAAAGTTGTTCTTTAGGAAATTCAACAGATGAAAAGTTTTACTAAAAAATTGTT
TCAACCTACTCTAAAAATGATTAAATTAAGATACCAAAAATTTAAAACATGAAATTCTCA
ATTGTACATACTGCAAAAGAAGTTGAATACACAGCTGATGGCTTTAGAAATAAAAATAAA
GATGAGATTTCTACTTTTCTAGATTAATGCATATCGTCATCTAGTAGTTCTGAAATATGT
TCTATATGGTAAGGAATTGGAGAAGTTAATATGACAGATATGGAGGTTTCTTCAAAAACA
GTGCAGGATATGTCAATTTCAGTGAGAAATACTTAGAAAAAATTAGAAAATAAGGGAAAA
GCTCAAAAATTTTTAGGAGCAAAATTCAGGGCTTAAATGAAAGATCTTATGGGAGAACTT
AATTCTTGTGATGTACATTTTATTAGATGTATTAAGCCTAATGAAGATAAAGTAAAAGAA
AAATTTGTTAGTCAATATGTACTCTTGCAGATAAGATATTTAGGTATTTTGGAAAGTATT
AAGGTGAGAAGAGAAGGATTTCCATGTAGAATGAGCTATGAAGAATTTTACACTAAATAT
CATGAGCTTGATGTTTTTAATAGTAAAAGAAACCATGTGAGAGATATCAAAGAATACTGG
CTTAGATGGAAGAATTTTATCAAATCTGAATAAGAAAAAGAATTACAAAACAAAATAAAA
GAATAGGAAGCAAAAGCTATTGAACAAAATAAAGCAATAGAAGAATAAAAGCAAATAGAA
AAAGAAGTAGAGGAAGAGGAAGAAAAAAAAGATGATGTTAAGGAATTAGAATAAGTAAAA
CCTTAAGAACCTGTAGTTTAAAAGAAGATTAACCCTAATGGACTTGAAATGGAAAGAGAA
GATATAAAGTCAGACGAGTTTACTTCTTAGGGTCTAAAAATTTGGCCTAACTTTTCAAAC
TTTACTAAGCCTTATAATTTATAAAATAAATTCTCTATCCCTAATGATATTTTAGACAAT
AATTAAAAATACTAAAATCCTAAGGAGCCAGAATAAAAAGACTTATAAAATTTAGAGTTT
AGTGATTAGTTTCTTTAATTAGTTCAATAATCATCATTCTTAGAATATTGCAATAATAAT
GTAAAAAGAGCTAAGAATTTCAGTAAAAAAATGTAAATTGCTAAAATAATGCAATACTAA
TCAAATAATCTAAGTGAATCTCTACTCTAACAATCAGATTCATTCAATGAAGATGCTACT
AAGATTTTTAGATCTTTATTAAAAATCTCTGGAAATAGAAATTCTCGTTTCTCTCCTAGA
TACCATTCTGATCTGATATTAAATCTATGTTATGGAAGGGATTCGGAATTAGATCCTAAC
TGCTATGTGATAGGTAAAAAAGTGGAAAATCCAGAAGATTAAAAAAAATAAAATAATAGA
AGAGAATCTAAAGAAAATAAAGATCTTGATTAGAGAAGAGGAAGCTATTTAAAAAATTAC
TCATCATAGGTATGCTAAAAATAATAAGGGAAAAATGGTGATTCAAATCAAGAAGAGGAT
GATTTAAGCCATGAAAACAAATTAGAATTAATGGCTAACTAAATCCTTCATGGTAATTTA
AATCATATAAGGGATGAAGTCTACTTTTAAATATGCAAATAGATTGCTGGAAACAAATCC
TAAGAGGCTAAAAAAAATTTATACAAATTTGCAGCTGAAATGTCCAATTTATTCGCACCT
TCTTAGGATGCCCTCTATCCATTAATAAATTTCTTCATGGATTAATCATTACAAGATCCA
AATGCTTAAAATAAAGAAGATGCTAAGTATATCGTCAGTAAACTTTCTGAATTTGCTAGA
GGATATGCAGTAGTTAAATTAATGAACCCTGATCAGTTAAAAAAATAAAGTATTTTAAAG
GTATTAAAGAATAATGATCCCCTTGAATTACAACTTTAAAAAAATAATAATTAGTAAGTC
TTGATTAACTATATAAACAAGATGTAACCCAGATAATTAATTCCTTCACATCAAGAAGTC
TCAAAAATTCATAATAGATAGTAAATATGCATAAAAATATATTTATTTGATGGTACCTAT
ATTTGGGTTCCTGCTGAATCATTAGAAACTGTTAAAAGCATAGTAGAAAAAGCATGTAGC
CAAATCGATATGAAAGAACGTTATTAATTTTTTAGCCTCTATGAAGTTCTTTATGAGTAA
GGAAAGGTTATGAAAGAAGCTTTTTTATTTGACAGAGTTAAAATAATGGATATTTTTAAT
TCCCATCAAATTACAACAGAGCTATAACAGAAAAAACATTCTAAAAATATTGAATTCAGA
ATTTATCTTAGGATAAGAGTTTATTACAAGCTTTTTAAAGATGATATAGATTCGATAAAT
ATGTTTTATATGCAAAATATATATGAAGTAAACTAAGGAAGGCTACCCTTAACTGAAAAC
TAAATAACTTAATTAGCTGCTCATTACTGCTATTCATCTCTAAAAACTTAACAGGGAAAT
GAGAAGAATATAGAAAATATGATAAATAAAGCTGTGCCTTAGTACGCAATTCAAAAGTAT
CATAATAGACAATGGGGTAATGAAGTAAGTGAAATTTATAAAAAACTTGAATACTAAAAT
GCTTTAGAAGCAAGATGGATGTATCTTGAAATAATCAGACCTCATGATCTCTTTTTAAGC
TACTAATTTGAATGCAGAATGTTTGTCTAATAAAAAACCGATTAGGGTTATAAGCTAGTT
TAAAATTAATAGATAATTTTAGGTATTAGACCTTTGTAAATAGTTATTTCTGATTTAGAA
CGTAAAACTATGTTGATAATTGATTTTTCTGAAATGACTAAATGGGGATAAAGCATAAGT
AGTAACTCCTACTTTCTAATATAGCATGAAAATTCAAACCTTTATGTGTTTGAAGTGTAA
GATGTGGAGTTGGCTGATTATCTAATTAATGCATATGTAAATTGGAAACTCGAAAGAAAT
CTTGATGATGCTTCGAACCCCACTTACAGTGATGTTATTACTTTCTTAGTTTCTGATAAT
GATCAAGCAAATTAAATTAAATGA

>TTHERM_01035740(gene)
ATGAGTATTGATTCACATTAAATAGAAAGAATTAAGACATCATGGATGCTTAATGGAGTT
TAATGCTGGGCTAAAGTAGCACCAGAGGAAAACTCCGAGCTTATGTTTCGTAGGGCTATT
ATTACAGGTTTAGATAATAAGCGTGAGCATGCATTCTTAAAATATGAGTTTCATCTTATC
TAAATTTAACAGCAAAAAGAAAAAGGTCCAGAAAAAGTACATGTTAGAGACTTAATAGAA
TGCAATTAGAATGCAGATAGTGAAAAATTTAAAGAAGGTTTTCCTGATATGGTTTCGATG
AATGTATTAAATGAAGCAGAAATTTTGAATAATGTTTGGTTGCGATATTCTAAAGACCTA
ATTTTTTCCTACATAGGACCTACATTAATTGTAATGAATCCCTACAAGAATGTAGAAAAG
CTTTTTAATGAAAAGGTTTTATAAGAATTTTAGAAACCTGCAATAAATAACAATTTCGAT
ATAAAGTAGCATTAGCCTCATGTCTATGCAGTAACTACATTAGCTTATTAGTAGCTATTT
ATGAATTAAAAGAACCAGGCAATAGTAATTAGTGGAGAATCAGGAGCTGGTAAGACTGAA
AATGCTAAATATTGTATGGCTTTTTTAACTTCTTTAAGTAATGAAACAACTAAGCAGTAA
CGCCCAAAAAAGAAAACTTAATTGGCGAACTAATTAAATAGATATTCTACAATGAGATAT
TCTTCAGTAGTAGCTAGCAACATCTCAGATTCTTAATATACTGAAGACTCTATACTTTAA
TTAAAGGATACATCGATTGAAGAGCGTATTCTTAGATGCAACCCAATTTTGGAAGCGTTT
GGTAATGCTAAAACAGTGAGAAATGATAATTCAAGTAGATTTGGTAAATATGTTCGTATT
TGGATTGGAAAGCATGATAAAAGAATTAAAGGAGCCTCAATTACAAATTACTTATTAGAA
AAAAGTAGAGTGACTCTACTATCATAAGGTGAAAGAAACTATCACATATTCTATCATTTT
TTATAAGGTAATTATTGAATCTTTCATTATTTTCAAAACATTTTGATTAAAAAGAAATGC
ATACAGTATTATTCATATAAATAGATTACTTAACATTTAGATTTTTAATTAAATTAGCTA
CATTTAATTCCAAAAGAATTTATCAATCTATATTAATTATAATTAAAATTTGATCCTTGA
GAATTAATATTGGTGTAACTATTTTAAATTAAAAAATTCAATAAATTTTTAGGAAATTTG
TTTCCCATAAAATTGACAAAAAATTAAATCATAAGATAGTTATGAATAAATAAATTATAA
CTAAAATACTCAAATAATTTTATTTATTTTAGATCAAAATATTTATTTTAAGTAAAGCAA
ATTAAGAAATTTACTAAGTAAAATAATTTCAACGAAATTAAATTTTTTATTCATATTTTT
AACAAATTTACTGAAGAAATATGTAGGAATTGTTTATATAAAGCTAAGATTAAGCAAGAA
ATAAAATTAGATTTTATTTTTTATATTTTTCCTTATCTATTAAAATATAAAATTTCATAA
AAATATATAAAAAGTAATAGTTTTGAATTTGGTATAATTTATTTATTTAAAATAGGATTA
GAAACTTCACAACTTAAAACTTATAAACTTGTGGAAAAAAATGGTAATAGAATAGATTTA
AAAAATTTTAATTATTTAAATTAAACTAATGTGTACGAAATAAGCTCCTTTCCTAGTGAT
AAAATAATGATTGATTAGATTATTGAATCCTTTGAGAAAATGGAGATTGATTCATACTAG
TAAGTAGCTATTTTTAAAGTTTTATCAGCTATTCTTTATATTGGAAATATTGAGTTTGAT
AGCTCAACATATACAGATAATACTCCTTGTAGTATAAAAAACTAAGATATCATATAAACT
GTTTCTGAACTTTTAGAAATAAATTAGTAAGATAAAATTTTGAAGTCAATTATATTTAAA
ATACGTTAAGTTGGTAGCTAGGTAAATTATTACTTTTAAAATGACTTTATATTGAAAATA
TAATCTAAAAATAAGGTTATGGAAACTCCAGTGAATGTTGAAGAGTGCAAAATTAATAGG
GATTCATTAGCGAGAGCTCTTTATGATAAAATGTTTACATGGATAGTTTAATCATTAAAT
ATGGAAATTTTACCTTAGAATAGTAATCCTAACGAATGTTTAAGTCTCGGATTGCTAGAT
ATTTTTGGGTTTGAGAACTTTAAGGTCAATTCTTTTGAATAATTATGCATCAACTTCACA
AATGAGCGCTTGCAATAGCTATATATTGTATATGTGTTTAAAGCTGAAGAAGAAGAGTTT
AAAAAAGAAGGTCTTAAAGTCCATAGCTTAGAACTTTCTTATTAAGATAATTAAGTTATT
ATAGATACAATGGATAAGCCACCTAATGGTATTTTTGATCTTCTAGATGAAAGTTGTTCT
TTAGGAAATTCAACAGATGAAAAGTTTTACTAAAAAATTGTTTCAACCTACTCTAAAAAT
GATTAAATTAAGGTACTATTTGATTTTTCTTATTTAAATCTTTAAAAAAATTTGTTTAAT
TTGAAAAATAAAACCAATAAAATTTAGCCTTAAATATTTAATTTTTAAAAAATAAAATTA
TTTAAGATACCAAAAATTTAAAACATGAAATTCTCAATTGTACATACTGCAAAAGAAGTT
GAATACACAGCTGATGGCTTTAGAAATAAAAATAAAGATGAGATTTCTACTTTTCTAGAT
TAATGCATATCGTCATCTAGTAGTTCTGAAATATGTTCTATATGGTAAGGAATTGGAGAA
GTTAATATGACAGATATGGAGGTTTCTTCAAAAACAGTGCAGGATATGTCAATTTCAGTG
AGAAATACTTAGAAAAAATTAGAAAATAAGGGAAAAGCTCAAAAATTTTTAGGAGCAAAA
TTCAGGGCTTAAATGAAAGATCTTATGGGAGAACTTAATTCTTGTGATGTACATTTTATT
AGATGTATTAAGCCTAATGAAGATAAAGTAAAAGAAAAATTTGTTAGTCAATATGTACTC
TTGCAGATAAGATATTTAGGTATTTTGGAAAGTATTAAGGTGAGAAGAGAAGGATTTCCA
TGTAGAATGAGCTATGAAGAATTTTACACTAAATATCATGAGCTTGATGTTTTTAATAGG
TAAATTAATAGGACAAGAATCTTTTAATAACTTTTTTTTTAGAAAAATAACATTATAGAG
GCACTTAGATATGAAACAAGATATGCCAGGATTGTGTAGAGAATTGTTATTTAGAGTTGT
AAAAGATGTTAACAAAAAAGAAGTTCTATTTGGTTAAACTAAGTTGTACTTAAAAGTTTA
GCCATCAACAGAGTTAGATAATAGATTAATTAAATGGTGGTAGTTTAAAAATGATTAGGC
TGGTAAAATCTAAGGATAGTGGGAAGTTTACAATAACAGAAAAGTTATTAAAGAAAATTT
AAAGATTATAAAAAATGCTGTTAAAAGTTTTGTTAAACTTTAAGCTATTTATAAAATGAA
AGTCTAAAAAAAAGCATATCTTAAGACATTATAATAGAAAAAGGGAATAGAAATACTTTA
GAAAATACAAAAAAAAATGCAACAAGCTAAATTAAAAGAAGTACTAAAACTATGGGTGGA
TAAAATAAAAACATAAAAAAAGGGAGATAAATGGTCTAATGCAGTATCGAAAGTTTGTAA
TATAAGTAAAAGAAACCATGTGAGAGATATCAAAGAATACTGGCTTAGATGGAAGAATTT
TATCAAATCTGAATAAGAAAAAGAATTACAAAACAAAATAAAAGAATAGGAAGCAAAAGC
TATTGAACAAAATAAAGCAATAGAAGAATAAAAGCAAATAGAAAAAGAAGTAGAGGAAGA
GGAAGAAAAAAAAGATGATGTTAAGGAATTAGAATAAGTAAAACCTTAAGAACCTGTAGT
TTAAAAGAAGTAAGTTTAAAGTTAAATAGTTATTTAAATTTTATAAAAAACTTTAATTTA
TCAATCAGGATTAACCCTAATGGACTTGAAATGGAAAGAGAAGATATAAAGTCAGACGAG
TTTACTTCTTAGGGTCTAAAAATTTGGCCTAACTTTTCAAACTTTACTAAGCCTTATAAT
TTATAAAATAAATTCTCTATCCCTAATGATATTTTAGACAATAATTAAAAATACTAAAAT
CCTAAGGAGCCAGAATAAAAAGACTTATAAAATTTAGAGTTTAGTGATTAGTTTCTTTAA
TTAGTTCAATAATCATCATTCTTAGAATATTGCAATAATAATGTAAAAAGAGCTAAGAAT
TTCAGTAAAAAAATGTAAATTGCTAAAATAATGCAATACTAATCAAATAATCTAAGTGAA
TCTCTACTCTAACAATCAGATTCATTCAATGAAGATGCTACTAAGATTTTTAGATCTTTA
TTAAAAATCTCTGGAAATAGAAATTCTCGTTTCTCTCCTAGATACCATTCTGATCTGATA
TTAAATCTATGTTATGGAAGGTTGATAATACTCTTTTTTATATTTTGAATTTTACATTTA
AATTTTATTTTATTCTATTTATAGGGATTCGGAATTAGATCCTAACTGCTATGTGATAGG
TAAAAAAGTGGAAAATCCAGAAGATTAAAAAAAATAAAATAATAGAAGAGAATCTAAAGA
AAATAAAGATCTTGATTAGAGAAGAGGAAGCTATTTAAAAAATTACTCATCATAGGTATG
CTAAAAATAATAAGGGAAAAATGGTGATTCAAATCAAGAAGAGGATGATTTAAGCCATGA
AAACAAATTAGAATTAATGGCTAACTAAATCCTTCATGGTAATTTAAATCATATAAGGGA
TGAAGTCTACTTTTAAATATGCAAATAGATTGCTGGAAACAAATCCTAAGAGGCTAAAAA
AAATTTATACAAATTTGCAGCTGAAATGTCCAATTTATTCGCACCTTCTTAGGATGCCCT
CTATCCATTAATAAATTTCTTCATGGATTAATCATTACAAGATCCAAATGCTTAAAATAA
AGAAGATGCTAAGTATATCGTCAGTAAACTTTCTGAATTTGCTAGAGGATATGCAGTAGT
TAAATTAATGAACCCTGATCAGTTAAAAAAATAAAGTATTTTAAAGGTATTAAAGAATAA
TGATCCCCTTGAATTACAACTTTAAAAAAATAATAATTAGTAAGTCTTGATTAACTATAT
AAACAAGATGTAACCCAGATAATTAATTCCTTCACATCAAGAAGTCTCAAAAATTCATAA
TAGATAGTAAATATGCATAAAAATATATTTATTTGATGGTACCTATATTTGGGTTCCTGC
TGAATCATTAGAAACTGTTAAAAGCATAGTAGAAAAAGCATGTAGCCAAATCGATATGAA
AGAACGTTATTAATTTTTTAGCCTCTATGAAGTTCTTTATGAGTAAGGAAAGGTTATGAA
AGAAGCTTTTTTATTTGACAGAGTTAAAATAATGGATATTTTTAATTCCCATCAAATTAC
AACAGAGCTATAACAGAAAAAACATTCTAAAAATATTGAATTCAGAATTTATCTTAGGAT
AAGAGTTTATTACAAGCTTTTTAAAGATGATATAGATTCGATAAATATGTTTTATATGCA
AAATATATATGAAGTAAACTAAGGAAGGCTACCCTTAACTGAAAACTAAATAACTTAATT
AGCTGCTCATTACTGCTATTCATCTCTAAGTAATTAATCATTTTTTAAAAAAATATTAAA
CTTTAATCTATTAAATTAAAAAACTGTTTTAAAAGTACCAATTAAATTTATTCTACCTCA
AACAAACATAATTTAATGTAATAAATTTTTCCTAATTAAAAAAGTGCTTAAGCTTAAAAA
TTGGTTATAATTATTTTTTTTTTCCATAAAATATTATGAATTTTATTTACTTACTATATT
CCCTTATTTCTCAAATCTTGTAATTAGCAAAAAGAAGTGAAGTATATGAATTAATAGTAT
CAAAAAATAGTCAAAAATAATGTTTTTTTTTTGTAGGGAATATGGTATTTAGTAAAATTT
AATCTAAAAATAAAAAATATTTTAATTTAAAATTAGAAACTTAACAGGGAAATGAGAAGA
ATATAGAAAATATGATAAATAAAGCTGTGCCTTAGTACGCAATTCAAAAGTATCATAATA
GACAATGGGGTAATGAAGTAAGTGAAATTTATAAAAAACTTGAATACTAAAATGCTTTAG
AAGCAAGATGGATGTATCTTGAAATAATCAGACCTCATGATCTCTTTTTAAGCTACTAAT
TTGAATGCAGAATGTTTGTCTAATAAAAAACCGATTAGGGTTATAAGCTAGTTTAAAATT
AATAGATAATTTTAGGTATTAGACCTTTGTAAATAGTTATTTCTGATTTAGAACGTAAAA
CTATGTTGATAATTGATTTTTCTGAAATGACTAAATGGGGATAAAGCATAAGTAGTAACT
CCTACTTTCTAATATAGCATGAAAATTCAAACCTTTATGTGTTTGAAGTGTAAGATGTGG
AGTTGGCTGATTATCTAATTAATGCATATGTAAATTGGAAACTCGAAAGAAATCTTGATG
ATGCTTCGAACCCCACTTACAGTGATGTTATTACTTTCTTAGTTTCTGATAATGATCAAG
CAAATTAAATTAAATGA

>TTHERM_01035740(protein)
MSIDSHQIERIKTSWMLNGVQCWAKVAPEENSELMFRRAIITGLDNKREHAFLKYEFHLI
QIQQQKEKGPEKVHVRDLIECNQNADSEKFKEGFPDMVSMNVLNEAEILNNVWLRYSKDL
IFSYIGPTLIVMNPYKNVEKLFNEKVLQEFQKPAINNNFDIKQHQPHVYAVTTLAYQQLF
MNQKNQAIVISGESGAGKTENAKYCMAFLTSLSNETTKQQRPKKKTQLANQLNRYSTMRY
SSVVASNISDSQYTEDSILQLKDTSIEERILRCNPILEAFGNAKTVRNDNSSRFGKYVRI
WIGKHDKRIKGASITNYLLEKSRVTLLSQGERNYHIFYHFLQGLETSQLKTYKLVEKNGN
RIDLKNFNYLNQTNVYEISSFPSDKIMIDQIIESFEKMEIDSYQQVAIFKVLSAILYIGN
IEFDSSTYTDNTPCSIKNQDIIQTVSELLEINQQDKILKSIIFKIRQVGSQVMETPVNVE
ECKINRDSLARALYDKMFTWIVQSLNMEILPQNSNPNECLSLGLLDIFGFENFKVNSFEQ
LCINFTNERLQQLYIVYVFKAEEEEFKKEGLKVHSLELSYQDNQVIIDTMDKPPNGIFDL
LDESCSLGNSTDEKFYQKIVSTYSKNDQIKIPKIQNMKFSIVHTAKEVEYTADGFRNKNK
DEISTFLDQCISSSSSSEICSIWQGIGEVNMTDMEVSSKTVQDMSISVRNTQKKLENKGK
AQKFLGAKFRAQMKDLMGELNSCDVHFIRCIKPNEDKVKEKFVSQYVLLQIRYLGILESI
KVRREGFPCRMSYEEFYTKYHELDVFNSKRNHVRDIKEYWLRWKNFIKSEQEKELQNKIK
EQEAKAIEQNKAIEEQKQIEKEVEEEEEKKDDVKELEQVKPQEPVVQKKINPNGLEMERE
DIKSDEFTSQGLKIWPNFSNFTKPYNLQNKFSIPNDILDNNQKYQNPKEPEQKDLQNLEF
SDQFLQLVQQSSFLEYCNNNVKRAKNFSKKMQIAKIMQYQSNNLSESLLQQSDSFNEDAT
KIFRSLLKISGNRNSRFSPRYHSDLILNLCYGRDSELDPNCYVIGKKVENPEDQKKQNNR
RESKENKDLDQRRGSYLKNYSSQVCQKQQGKNGDSNQEEDDLSHENKLELMANQILHGNL
NHIRDEVYFQICKQIAGNKSQEAKKNLYKFAAEMSNLFAPSQDALYPLINFFMDQSLQDP
NAQNKEDAKYIVSKLSEFARGYAVVKLMNPDQLKKQSILKVLKNNDPLELQLQKNNNQQV
LINYINKMQPRQLIPSHQEVSKIHNRQQICIKIYLFDGTYIWVPAESLETVKSIVEKACS
QIDMKERYQFFSLYEVLYEQGKVMKEAFLFDRVKIMDIFNSHQITTELQQKKHSKNIEFR
IYLRIRVYYKLFKDDIDSINMFYMQNIYEVNQGRLPLTENQITQLAAHYCYSSLKTQQGN
EKNIENMINKAVPQYAIQKYHNRQWGNEVSEIYKKLEYQNALEARWMYLEIIRPHDLFLS
YQFECRMFVQQKTDQGYKLVQNQQIILGIRPLQIVISDLERKTMLIIDFSEMTKWGQSIS
SNSYFLIQHENSNLYVFEVQDVELADYLINAYVNWKLERNLDDASNPTYSDVITFLVSDN
DQANQIK

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Identifiers and Description

Gene Model Identifier

Standard Name

Aliases

Description

Genome Browser (Macronucleus)

Genome Browser (Micronucleus)

External Links

Gene Ontology Annotations

Cellular Component

Molecular Function

Domains

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

Tetrahymena Stock Center

Homologs

General Information

Associated Literature

Sequences

Wiki Links

External Links

Source	Identifier	Score
Tetrahymena borealis	EI9_19646.1	9.997093137033517e-262
	Description: myosin head, motor domain-containing protein (1543 aa)
Oxytricha	Contig18292.0.g108	4.999822746981985e-134
	Description: Myosin head (motor domain)
DictyBase	DDB_G0288679	9.997006461365152e-115
	Description: myoE on chromosome: 5 position 1829072 to 1832587
SGD	YOR326W	2.0009157491910723e-107
	Description: MYO2 One of two type V myosin motors (along with MYO4) involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle
WormBase	WBGene00002038	1.0002646133906571e-103
	Description: locus:hum-5 status:Confirmed UniProt:G5ECZ0 protein_id:CAA84673.1

No.	Gene Name(s)	Paragraph Text
10	MYO1, MYO2, MYO3, MYO4, MYO5, MYO4 , MYO9, MYO10, MYO11, MYO12, MYO13	Proteins of the myosin superfamily are ATP-dependent molecular motors that travel unidirectionally along actin filaments. The myosin heavy chain proteins are comprised of three domains: a head (motor) domain responsible for ATP hydrolysis at the N-terminus, a neck (lever arm) region, and a C-terminal tail region. Thirteen predicted myosin heavy chain genes have been identified in the Tetrahymena genome and named MYO1-MYO13. A phylogenetic analysis comparing these predicted proteins with the 19 previously identified myosin classes suggests that Myo1p-Myo12p belong to a previously undescribed class of myosins. This new family, designated Class XX, does not include Myo13p, which did not branch with this class or any of the other classes in the analysis. The neck and tail regions of the Tetrahymena myosins include a variety of domains characterized in other myosin classes, with each protein containing one or more of the following domains: coiled-coil (which may support dimerization); IQ motif (binding sites for calmodulin or calmodulin-like proteins); FERM domain (Four-point-one protein, Ezrin, Radixin, Moesin homology); and MyTH4 domain (Myosin Tail Homology 4).